| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Johnson RC and Shah SN | Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. | 1974 | Arch. Biochem. Biophys. | pmid:4460877 |
| Lepesheva GI et al. | Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET. | 2007 | Arch. Biochem. Biophys. | pmid:17585868 |
| Fryberg M et al. | Sterol biosynthesis in antibiotic-resistant yeast: nystatin. | 1974 | Arch. Biochem. Biophys. | pmid:4597559 |
| Kolesnikova MD et al. | Lanosterol biosynthesis in plants. | 2006 | Arch. Biochem. Biophys. | pmid:16445886 |
| Debeljak N et al. | Many facets of mammalian lanosterol 14alpha-demethylase from the evolutionarily conserved cytochrome P450 family CYP51. | 2003 | Arch. Biochem. Biophys. | pmid:12464255 |
| Leonard DA et al. | Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 3 beta-hydroxy-lanost-8-en-32-al, an intermediate in the conversion of lanosterol to cholesterol. | 1994 | Arch. Biochem. Biophys. | pmid:8161198 |
| STOKES WM | The separation of the compounds of the lanosterol group present in "isocholesterol" by chromatography of the p-iodobenzoates-I 131 and benzoates. | 1957 | Arch. Biochem. Biophys. | pmid:13425621 |
| Anderson JA et al. | 15-substituted lanosterols: post-transcriptional suppressors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1995 | Arch. Biochem. Biophys. | pmid:7840615 |
| Nes WD et al. | Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. | 2009 | Arch. Biochem. Biophys. | pmid:19014901 |
| Pikuleva I and Javitt NB | Novel sterols synthesized via the CYP27A1 metabolic pathway. | 2003 | Arch. Biochem. Biophys. | pmid:14622972 |
| Ness GC et al. | Regulation of hepatic lanosterol 14 alpha-demethylase gene expression by dietary cholesterol and cholesterol-lowering agents. | 2001 | Arch. Biochem. Biophys. | pmid:11697861 |
| Nes WD et al. | Metabolism of 24(R,S),25-epiminolanosterol to 25-aminolanosterol and lanosterol by Gibberella fujikuroi. | 1989 | Arch. Biochem. Biophys. | pmid:2751307 |
| Clayton PT | Disorders of cholesterol biosynthesis. | 1998 | Arch. Dis. Child. | pmid:9579167 |
| Wang W et al. | Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives. | 2009 | Arch. Pharm. (Weinheim) | pmid:19899102 |
| Sun B et al. | Two novel A-seco-rearranged lanostane triterpenoids from Abies sachalinensis. | 2008 | Arch. Pharm. Res. | pmid:19099219 |
| Kojima M et al. | Altered gene expression of hepatic lanosterol 14alpha-demethylase (CYP51) in lead nitrate-treated rats. | 2002 | Arch. Toxicol. | pmid:12111004 |
| Rozenberg O et al. | Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615663 |
| Burkhardt R et al. | Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21252064 |
| Burgess B et al. | Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18599800 |
| Zhao LW et al. | Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells. | 2014 | Asian Pac. J. Cancer Prev. | pmid:24815470 |