| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bildziukevich U et al. | Amides derived from heteroaromatic amines and selected steryl hemiesters. | 2013 | Steroids | pmid:24145008 |
| Lewis D et al. | Enzyme inhibition during the conversion of squalene to cholesterol. | 1995 | Steroids | pmid:7482633 |
| Dias JR and Gao H | 13C nuclear magnetic resonance data of lanosterol derivatives--profiling the steric topology of the steroid skeleton via substituent effects on its 13C NMR. | 2009 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:19800838 |
| Aoyama Y and Yoshida Y | [Role of the microsomal electron-transport system in lanosterol demethylation (author's transl)]. | 1981 | Seikagaku | pmid:7320588 |
| Quinlan RA | DRUG DISCOVERY. A new dawn for cataracts. | 2015 | Science | pmid:26542559 |
| Imai H et al. | Angiotoxicity of oxygenated sterols and possible precursors. | 1980 | Science | pmid:7352277 |
| Maugh TH | Completing the puzzle of steroid synthesis, a mystery in the biological synthesis of steroids is solved, providing a new approach to chemical synthesis of the compounds. | 1982 | Science | pmid:7146911 |
| Ciavatti M et al. | Oral contraceptives, lanosterol, and platelet hyperactivity in rat. | 1980 | Science | pmid:7433990 |
| AÄimoviÄ J et al. | Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis. | 2016 | Sci Rep | pmid:27334049 |
| Davenport RJ | How low can you go? | 2005 | Sci Aging Knowledge Environ | pmid:15772415 |
| Abrahamsson H et al. | Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation. | 2008 | Scand. J. Gastroenterol. | pmid:18788050 |
| Valle LB et al. | [Sterols in salivary gland. I. Isolation and characterization of lanosterol in the ox submandibular salivary gland]. | 1974 Jul-Dec | Rev Fac Odontol Sao Paulo | pmid:4536017 |
| Xu Y et al. | Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. | 2009 | Respir. Res. | pmid:19344509 |
| Liu JY et al. | Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China. | 2015 | Res. Microbiol. | pmid:25748216 |
| Hemmi H | Differential cytotoxicity of cytosine arabinoside toward murine leukemia L1210 cells and murine bone marrow progenitor cells inhibited in nucleoside transport by cimicifugoside. | 1981 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6791252 |
| Song X et al. | Expression and regulation of lanosterol 14alpha-demethylase in mouse embryo and uterus during the peri-implantation period. | 2008 | Reprod. Fertil. Dev. | pmid:19007561 |
| Sharpe RL et al. | Investigation of de novo cholesterol synthetic capacity in the gonads of goldfish (Carassius auratus) exposed to the phytosterol beta-sitosterol. | 2006 | Reprod. Biol. Endocrinol. | pmid:17118198 |
| Yun SJ et al. | Aberrant phenotypes of transgenic mice expressing dimeric human erythropoietin. | 2012 | Reprod. Biol. Endocrinol. | pmid:22284751 |
| Tallman KA et al. | Probes for protein adduction in cholesterol biosynthesis disorders: Alkynyl lanosterol as a viable sterol precursor. | 2017 | Redox Biol | pmid:28258022 |
| Bruneau JM et al. | Drug induced proteome changes in Candida albicans: comparison of the effect of beta(1,3) glucan synthase inhibitors and two triazoles, fluconazole and itraconazole. | 2003 | Proteomics | pmid:12627386 |