| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Das A et al. | A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway. | 2015 | Tumour Biol. | pmid:25864108 |
| Shanmugam PM et al. | Effect of lanosterol on human cataract nucleus. | 2015 | Indian J Ophthalmol | pmid:26862091 |
| Mendiara I et al. | Online solid-phase extraction-liquid chromatography-mass spectrometry to determine free sterols in human serum. | 2015 | Talanta | pmid:25476366 |
| Mosa RA et al. | In vivo antihyperglycemic activity of a lanosteryl triterpene from Protorhus longifolia. | 2015 | Molecules | pmid:26205060 |
| Sagatova AA et al. | Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase. | 2015 | Antimicrob. Agents Chemother. | pmid:26055382 |
| Price CL et al. | Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. | 2015 | Appl. Environ. Microbiol. | pmid:25746994 |
| Zhang SS et al. | Three new lanostanoids from the mushroom Ganoderma tropicum. | 2015 | Molecules | pmid:25690289 |
| Wang J et al. | Protective Effect of Eburicoic Acid of the Chicken of the Woods Mushroom, Laetiporus sulphureus (Higher Basidiomycetes), Against Gastric Ulcers in Mice. | 2015 | Int J Med Mushrooms | pmid:26559696 |
| Quinlan RA | DRUG DISCOVERY. A new dawn for cataracts. | 2015 | Science | pmid:26542559 |
| Kuo YH et al. | Antidiabetic and Antihyperlipidemic Properties of a Triterpenoid Compound, Dehydroeburicoic Acid, from Antrodia camphorata in Vitro and in Streptozotocin-Induced Mice. | 2015 | J. Agric. Food Chem. | pmid:26503742 |
| Wang GW et al. | Lanostane-type triterpenoids from Abies faxoniana and their DNA topoisomerase inhibitory activities. | 2015 | Phytochemistry | pmid:25986863 |
| Kürten C et al. | Overexpression of functional human oxidosqualene cyclase in Escherichia coli. | 2015 | Protein Expr. Purif. | pmid:25962741 |
| Yin X et al. | Four lanostane-type triterpenes from the fruiting bodies of mushroom Laetiporus sulphureus var. miniatus. | 2015 | J Asian Nat Prod Res | pmid:25916960 |
| O'Keeffe R et al. | Synthesis of novel 24-amino-25,26,27-trinorlanost-8-enes: cytotoxic and apoptotic potential in U937 cells. | 2015 | Bioorg. Med. Chem. | pmid:25800433 |
| Liu JY et al. | Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China. | 2015 | Res. Microbiol. | pmid:25748216 |
| Leoni V and Caccia C | The impairment of cholesterol metabolism in Huntington disease. | 2015 | Biochim. Biophys. Acta | pmid:25596342 |
| Zhang SS et al. | Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes. | 2015 | Phytochemistry | pmid:25577284 |
| Jamila N et al. | Molecular docking studies and in vitro cholinesterase enzyme inhibitory activities of chemical constituents of Garcinia hombroniana. | 2015 | Nat. Prod. Res. | pmid:25219673 |
| Chen CL et al. | Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. | 2015 | PLoS ONE | pmid:26448474 |
| Marco-Jiménez F et al. | Effect of lanosterol on the in vitro maturation in semi-defined culture system of prepubertal ewe oocytes. | 2014 | Zygote | pmid:21838962 |