| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cantillo-Ciau Z et al. | Two new 24-isopropenyl-lanostanoids from Tillandsia brachycaulos. | 2003 Sep-Oct | Z. Naturforsch., C, J. Biosci. | pmid:14577625 |
| Buckner FS et al. | Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase. | 2003 | Mol. Biochem. Parasitol. | pmid:14599667 |
| Pikuleva I and Javitt NB | Novel sterols synthesized via the CYP27A1 metabolic pathway. | 2003 | Arch. Biochem. Biophys. | pmid:14622972 |
| Ori K et al. | Lanosterol and tetranorlanosterol glycosides from the bulbs of Muscari paradoxum. | 2003 | Phytochemistry | pmid:14629999 |
| Cotman M et al. | A functional cytochrome P450 lanosterol 14 alpha-demethylase CYP51 enzyme in the acrosome: transport through the Golgi and synthesis of meiosis-activating sterols. | 2004 | Endocrinology | pmid:14630712 |
| Tang YJ and Zhong JJ | Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. | 2003 Nov-Dec | Biotechnol. Prog. | pmid:14656165 |
| Woo KC et al. | Phytoestrogen cimicifugoside-mediated inhibition of catecholamine secretion by blocking nicotinic acetylcholine receptor in bovine adrenal chromaffin cells. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14757852 |
| Ruf A et al. | The monotopic membrane protein human oxidosqualene cyclase is active as monomer. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14766201 |
| MARCUS S | Antibacterial activity of the triterpenoid acid (polyporenic acid C) and of ungulinic acid, metabolic products of Polyporus benzoinus (Wahl.) Fr. | 1952 | Biochem. J. | pmid:14925127 |
| Berger A et al. | Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. | 2004 | Lipids Health Dis | pmid:14969592 |
| Pan RL et al. | Two new cyclolanostanol glycosides from the aerial parts of Cimicifuga foetida. | 2004 | J Asian Nat Prod Res | pmid:14989382 |
| Zhao XH et al. | [Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015286 |
| Pan RL et al. | [Studies on the new triterpenoid saponin of the aerial part of Cimicifuga foetida]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015306 |
| Abe I et al. | Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase. | 2004 | J. Am. Chem. Soc. | pmid:15025461 |
| Lepesheva GI and Waterman MR | CYP51--the omnipotent P450. | 2004 | Mol. Cell. Endocrinol. | pmid:15026190 |
| Ye X et al. | Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. | 2004 | Mol. Biol. Rep. | pmid:15040456 |
| Aoyama Y et al. | Structural analysis of the interaction between the side-chain of substrates and the active site of lanosterol 14 alpha-demethylase (P-450(14)DM) of yeast. | 1992 | Biochim. Biophys. Acta | pmid:1504086 |
| Zuckermann MJ et al. | Modeling lipid-sterol bilayers: applications to structural evolution, lateral diffusion, and rafts. | 2004 | Meth. Enzymol. | pmid:15063652 |
| Jabra-Rizk MA et al. | Fungal biofilms and drug resistance. | 2004 | Emerging Infect. Dis. | pmid:15078591 |
| Nöllmann M et al. | The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin. | 2004 | Biophys. J. | pmid:15111427 |
| Xie H et al. | Roles of gonadotropins and meiosis-activating sterols in meiotic resumption of cultured follicle-enclosed mouse oocytes. | 2004 | Mol. Cell. Endocrinol. | pmid:15130520 |
| Martin-Creuzburg D and Von Elert E | Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata. | 2004 | J. Chem. Ecol. | pmid:15139303 |
| Chen YG et al. | Ananosic acids B and C, two new 18(13-->12)-abeo-lanostane triterpenoids from Kadsura ananosma. | 2004 | J. Nat. Prod. | pmid:15165154 |
| Moodley N et al. | Eucosterol-type nortriterpenoids from Merwilla natalensis. | 2004 | J. Nat. Prod. | pmid:15165167 |
| Kavtaradze LK et al. | Efficient routes to epimerically-pure side-chain derivatives of lanosterol. | 2004 | Steroids | pmid:15183688 |
| Dantas-Leite L et al. | Selective anti-Toxoplasma gondii activities of azasterols. | 2004 | Int. J. Antimicrob. Agents | pmid:15194134 |
| Barker KS et al. | Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans. | 2004 | J. Antimicrob. Chemother. | pmid:15201233 |
| Sheng C et al. | Homology modeling of lanosterol 14alpha-demethylase of Candida albicans and Aspergillus fumigatus and insights into the enzyme-substrate Interactions. | 2004 | J. Biomol. Struct. Dyn. | pmid:15214809 |
| Henriksen J et al. | Vesicle fluctuation analysis of the effects of sterols on membrane bending rigidity. | 2004 | Eur. Biophys. J. | pmid:15221234 |
| Weber JM et al. | Factors affecting homologous overexpression of the Saccharomyces cerevisiae lanosterol 14 alpha-demethylase gene. | 1992 | Yeast | pmid:1523885 |
| Adachi M et al. | Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome. | 2004 | Am. J. Med. Genet. A | pmid:15264278 |
| Cragun DL et al. | Undetectable maternal serum uE3 and postnatal abnormal sterol and steroid metabolism in Antley-Bixler syndrome. | 2004 | Am. J. Med. Genet. A | pmid:15266606 |
| Cao X et al. | Meiosis-activating sterol synthesis in rat preovulatory follicle: is it involved in resumption of meiosis? | 2004 | Biol. Reprod. | pmid:15269103 |
| Shim SH et al. | New lanostane-type triterpenoids from Ganoderma applanatum. | 2004 | J. Nat. Prod. | pmid:15270562 |
| Trösken ER et al. | Quantitation of lanosterol and its major metabolite FF-MAS in an inhibition assay of CYP51 by azoles with atmospheric pressure photoionization based LC-MS/MS. | 2004 | J. Am. Soc. Mass Spectrom. | pmid:15276168 |
| Lepesheva GI et al. | CYP51 from Trypanosoma brucei is obtusifoliol-specific. | 2004 | Biochemistry | pmid:15311940 |
| Hronská L et al. | Low concentrations of the non-ionic detergent Nonidet P-40 interfere with sterol biogenesis and viability of the yeast Saccharomyces cerevisiae. | 2004 | FEMS Microbiol. Lett. | pmid:15336428 |
| Javitt NB | Oxysteroids: a new class of steroids with autocrine and paracrine functions. | 2004 | Trends Endocrinol. Metab. | pmid:15380811 |
| Fernández C et al. | Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation. | 2004 | Exp. Cell Res. | pmid:15383319 |
| Rezen T et al. | New aspects on lanosterol 14alpha-demethylase and cytochrome P450 evolution: lanosterol/cycloartenol diversification and lateral transfer. | 2004 | J. Mol. Evol. | pmid:15383907 |
| Kavtaradze LK et al. | A low-toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixtures. | 2004 | Steroids | pmid:15465116 |
| Montero MT et al. | Geranylgeraniol regulates negatively caspase-1 autoprocessing: implication in the Th1 response against Mycobacterium tuberculosis. | 2004 | J. Immunol. | pmid:15470035 |
| Revankar SG et al. | Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474487 |
| Kojima M et al. | Lead nitrate-induced development of hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis. | 2004 | Toxicol. Lett. | pmid:15475176 |
| Godio RP et al. | Agrobacterium tumefaciens-mediated transformation of the antitumor clavaric acid-producing basidiomycete Hypholoma sublateritium. | 2004 | Curr. Genet. | pmid:15480676 |
| Adachi M et al. | Abnormal steroidogenesis in three patients with Antley-Bixler syndrome: apparent decreased activity of 17alpha-hydroxylase, 17,20-lyase and 21-hydroxylase. | 2004 | Pediatr Int | pmid:15491389 |
| Wu X et al. | New lanostane-type triterpenes from Fomes officinalis. | 2004 | Chem. Pharm. Bull. | pmid:15516768 |
| Thoma R et al. | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. | 2004 | Nature | pmid:15525992 |
| Aoki Y et al. | A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. II. Mode of action. | 1992 | J. Antibiot. | pmid:1556007 |
| Sun S et al. | The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15582556 |