| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shapiro BE and Gealt MA | Ergosterol and lanosterol from Aspergillus nidulans. | 1982 | J. Gen. Microbiol. | pmid:7050295 |
| Schroepfer GJ | Sterol biosynthesis. | 1982 | Annu. Rev. Biochem. | pmid:6810750 |
| Ciavatti M et al. | Biosynthesis of platelet lipids in relation to aggregation in women using oral contraceptives. | 1982 | Contraception | pmid:7116849 |
| Kling D and Gamble W | Cholesterol biosynthesis in polychlorinated biphenyl-treated rats. | 1982 | Environ. Res. | pmid:6802634 |
| Trzaskos JM et al. | Microsomal enzymes of cholesterol biosynthesis from lanosterol: a progress report. | 1982 | Lipids | pmid:6806557 |
| Maitra US et al. | Purification of a terminal oxygenase in demethylation of C-30 of lanosterol. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6816234 |
| Sarkar CP and Cenedella RJ | Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol. | 1982 | Lipids | pmid:6177997 |
| Pratt HP | Preimplantation mouse embryos synthesize membrane sterols. | 1982 | Dev. Biol. | pmid:7054002 |
| Carson DD et al. | Synthesis of steroids in postimplantation mouse embryos cultured in vitro. | 1982 | Dev. Biol. | pmid:7095272 |
| Ranganathan S et al. | Effect of pantethine on the biosynthesis of cholesterol in human skin fibroblasts. | 1982 | Atherosclerosis | pmid:7150392 |
| [Poisoning with a kind of Bitter Edible Gourd]. | 1983 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:6851770 | |
| Aoyama Y et al. | Buthiobate: a potent inhibitor for yeast cytochrome P-450 catalyzing 14 alpha-demethylation of lanosterol. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6414474 |
| Aoyama Y et al. | Altered cytochrome P-450 in a yeast mutant blocked in demethylating C-32 of lanosterol. | 1983 | J. Biol. Chem. | pmid:6409899 |
| Dull BJ et al. | The modulating effect of an inhibitor of cholesterolgenesis present in bovine milk upon the synthesis of cholesterol, dolichol and ubiquinone. | 1983 | Atherosclerosis | pmid:6661267 |
| Chen HW and Leonard DA | Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells. | 1984 | J. Biol. Chem. | pmid:6429139 |
| Yachnin S and Mannickarottu V | Increased 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis in freshly isolated hairy cell leukemia cells. | 1984 | Blood | pmid:6696995 |
| Leonard DA and Chen HW | Aphidicolin, a specific inhibitor of DNA polymerase alpha, inhibits conversion of lanosterol to C-27 sterols in mouse L cells. | 1984 | J. Biol. Chem. | pmid:6425279 |
| Ciavatti M et al. | Vitamin E prevents the platelet abnormalities induced by estrogen in rat. | 1984 | Contraception | pmid:6509982 |
| Witkowski A et al. | Inhibition of the biosynthesis of deoxyribonucleic acid, ribonucleic acid and protein in HeLa S3 cells by cucurbitacins, glucocorticoid-like cytotoxic triterpenes. | 1984 | Biochem. Pharmacol. | pmid:6546879 |
| Trzaskos JM et al. | Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation. | 1984 | J. Biol. Chem. | pmid:6208195 |
| Nakanishi S et al. | Preparation of 14C-labeled and unlabeled sterol intermediates from yeast using metabolic inhibitors. | 1984 | J. Biochem. | pmid:6397465 |
| McGregor L et al. | Effects of oral contraceptives, or lanosterol, on ADP-induced aggregation and binding of 125I-fibrinogen to rat platelets. | 1984 | Thromb. Res. | pmid:6719398 |
| Yoshida Y and Aoyama Y | Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. I. Purification and spectral properties. | 1984 | J. Biol. Chem. | pmid:6363414 |
| Aoyama Y et al. | Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes. | 1984 | J. Biol. Chem. | pmid:6420412 |
| Paik YK et al. | Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase. | 1984 | J. Biol. Chem. | pmid:6444198 |
| Kawata S et al. | Microsomal enzymes of cholesterol biosynthesis from lanosterol. Purification and characterization of delta 7-sterol 5-desaturase of rat liver microsomes. | 1985 | J. Biol. Chem. | pmid:3997841 |
| Rodriguez RJ et al. | Multiple functions for sterols in Saccharomyces cerevisiae. | 1985 | Biochim. Biophys. Acta | pmid:3904834 |
| Yeagle PL | Lanosterol and cholesterol have different effects on phospholipid acyl chain ordering. | 1985 | Biochim. Biophys. Acta | pmid:3986200 |
| Sonoda Y and Sato Y | Hypolipidemic effects of dietary 7-oxo-24,25-dihydrolanosterol. | 1985 | J. Pharmacobio-dyn. | pmid:4067814 |
| Evans JL and Gealt MA | The sterols of growth and stationary phases of Aspergillus nidulans cultures. | 1985 | J. Gen. Microbiol. | pmid:3884732 |
| Bloch K | Mycoplasmas as a tool for membrane research. | 1985 | Diagn. Microbiol. Infect. Dis. | pmid:4028661 |
| Goad LJ et al. | Sterols of ketoconazole-inhibited Leishmania mexicana mexicana promastigotes. | 1985 | Mol. Biochem. Parasitol. | pmid:4033689 |
| Plank L et al. | Effect of sterol incorporation on head group separation in liposomes. | 1985 | Chem. Phys. Lipids | pmid:3924423 |
| Yoshida Y et al. | Spectral properties of a novel cytochrome P-450 of a Saccharomyces cerevisiae mutant SG1. A cytochrome P-450 species having a nitrogenous ligand trans to thiolate. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3884012 |
| Beach DH et al. | Effects of ketoconazole on sterol biosynthesis by Trypanosoma cruzi epimastigotes. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3521598 |
| Panini SR et al. | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols. | 1986 | J. Lipid Res. | pmid:3559385 |
| Morisaki M et al. | Inhibitory effect of 15-oxygenated sterols on cholesterol synthesis from 24,25-dihydrolanosterol. | 1986 | J. Biochem. | pmid:3700366 |
| Shafiee A et al. | Oxidative demethylation of lanosterol in cholesterol biosynthesis: accumulation of sterol intermediates. | 1986 | J. Lipid Res. | pmid:3514778 |
| Ryder NS et al. | Inhibition of fungal and mammalian sterol biosynthesis by 2-aza-2,3-dihydrosqualene. | 1986 | FEBS Lett. | pmid:3525224 |
| Taylor FR et al. | 24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase. | 1986 | J. Biol. Chem. | pmid:3771561 |
| Kraemer FB and Spilman SD | Effects of ketoconazole on cholesterol synthesis. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3746668 |
| Feingold KR et al. | Effect of essential fatty acid deficiency on cutaneous sterol synthesis. | 1986 | J. Invest. Dermatol. | pmid:3772153 |
| Chen JK et al. | Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. | 1986 | Exp. Cell Res. | pmid:3943557 |
| Trzaskos JM et al. | Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process. | 1986 | J. Biol. Chem. | pmid:3782148 |
| Rippon JW | A new era in antimycotic agents. | 1986 | Arch Dermatol | pmid:3006601 |
| Aoyama Y and Yoshida Y | Evidence for the contribution of a sterol 14-reductase to the 14 alpha-demethylation of lanosterol by yeast. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2418830 |
| Paik YK et al. | Microsomal enzymes of cholesterol biosynthesis from lanosterol. Solubilization and purification of steroid 8-isomerase. | 1986 | J. Biol. Chem. | pmid:2422166 |
| Nes WD et al. | Control of fungal sterol C-24 transalkylation: importance to developmental regulation. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3767970 |
| Arisawa M et al. | Three new lanostanoids from Ganoderma lucidum. | 1986 Jul-Aug | J. Nat. Prod. | pmid:3783158 |
| Aoyama Y et al. | Metabolism of 32-hydroxy-24,25-dihydrolanosterol by purified cytochrome P-45014DM from yeast. Evidence for contribution of the cytochrome to whole process of lanosterol 14 alpha-demethylation. | 1987 | J. Biol. Chem. | pmid:3543000 |