MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pemán J et al. | Voriconazole in the management of nosocomial invasive fungal infections. | 2006 | Ther Clin Risk Manag | pmid:18360588 |
Mendiara I et al. | Online solid-phase extraction-liquid chromatography-mass spectrometry to determine free sterols in human serum. | 2015 | Talanta | pmid:25476366 |
Yding Andersen C and Byskov AG | Progesterone and 17 alpha-OH-progesterone in concentrations similar to that of preovulatory follicular fluid is without effect on resumption of meiosis in mouse cumulus enclosed oocytes cultured in the presence of hypoxanthine. | 2002 | Steroids | pmid:12398990 |
Nes WD et al. | Concerning the role of 24,25-dihydrolanosterol and lanostanol in sterol biosynthesis by cultured cells. | 1989 Mar-May | Steroids | pmid:2799854 |
Bühler H et al. | Endogenous inhibitors of 11 beta-OHSD: existence and possible significance. | 1994 | Steroids | pmid:8191542 |
Kavtaradze LK et al. | A low-toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixtures. | 2004 | Steroids | pmid:15465116 |
Iglesias J and Gibbons GF | Oxidative metabolism of cholesterol precursors: sensitivity to ketoconazole, an inhibitor of cytochrome P-450. | 1989 Mar-May | Steroids | pmid:2799848 |
Kavtaradze LK et al. | Efficient routes to epimerically-pure side-chain derivatives of lanosterol. | 2004 | Steroids | pmid:15183688 |
Javitt NB | Oxysterols: novel biologic roles for the 21st century. | 2008 | Steroids | pmid:18068744 |
Fakheri RJ and Javitt NB | Autoregulation of cholesterol synthesis: physiologic and pathophysiologic consequences. | 2011 | Steroids | pmid:20951718 |