| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Aoyama Y et al. | Metabolism of 32-hydroxy-24,25-dihydrolanosterol by purified cytochrome P-45014DM from yeast. Evidence for contribution of the cytochrome to whole process of lanosterol 14 alpha-demethylation. | 1987 | J. Biol. Chem. | pmid:3543000 |
| Sonoda Y et al. | A simplified synthesis of 32-oxygenated lanosterol derivatives. | 1987 | Chem. Pharm. Bull. | pmid:3594666 |
| Saucier SE et al. | Accumulation of regulatory oxysterols, 32-oxolanosterol and 32-hydroxylanosterol in mevalonate-treated cell cultures. | 1987 | J. Biol. Chem. | pmid:3654653 |
| Gevers Leuven JA et al. | The effect of cyclandelate on cholesterol metabolism in patients with familial hypercholesterolaemia. | 1987 | Drugs | pmid:3304952 |
| Bard M et al. | Characterization of a cytochrome P450 deficient mutant of Candida albicans. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3307785 |
| Tabacik C et al. | Regulation of cholesterol biosynthesis at a stage after the 3-hydroxy-3-methylglutaryl-CoA reductase step, in normal and leukemic (L2C) guinea pig lymphocytes. | 1987 | Biochim. Biophys. Acta | pmid:3651496 |
| M'Baya B and Karst F | In vitro assay of squalene epoxidase of Saccharomyces cerevisiae. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3307781 |
| Favata MF et al. | Modulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by azole antimycotics requires lanosterol demethylation, but not 24,25-epoxylanosterol formation. | 1987 | J. Biol. Chem. | pmid:3624255 |
| Trzaskos JM et al. | In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. | 1987 | J. Biol. Chem. | pmid:3624256 |
| Faust J and Krieger M | Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant. | 1987 | J. Biol. Chem. | pmid:3643925 |
| Lange Y and Muraski MF | Cholesterol is not synthesized in membranes bearing 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1987 | J. Biol. Chem. | pmid:3558346 |
| Aoyama Y et al. | Isolation and characterization of an altered cytochrome P-450 from a yeast mutant defective in lanosterol 14 alpha-demethylation. | 1987 | J. Biol. Chem. | pmid:3115990 |
| Reinhart MP et al. | Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver. | 1987 | J. Biol. Chem. | pmid:3597431 |
| Pinkerton FD et al. | Inhibitors of sterol synthesis. 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol induces changes in the sterol composition and the morphology of CHO-K1 cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3196343 |
| Sekigawa Y et al. | Metabolism of 32-hydroxylated 24,25-dihydrolanosterols by partially purified cytochrome P-450(14)DM from rat liver microsomes. | 1988 | Chem. Pharm. Bull. | pmid:3240513 |
| Parish EJ et al. | A facile synthesis of lanost-8-en-3 beta-ol-24-one (24-ketolanosterol). An inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1988 | Chem. Phys. Lipids | pmid:3242953 |
| Cooper AB et al. | Synthesis and antifungal properties of 14-aminomethyl-substituted lanosterol derivatives. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3214062 |
| Raederstorff D and Rohmer M | Polyterpenoids as cholesterol and tetrahymanol surrogates in the ciliate Tetrahymena pyriformis. | 1988 | Biochim. Biophys. Acta | pmid:3130105 |
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| Aguilera JA et al. | Regulation of hepatic cholesterogenesis by polar steroids accumulated after cholesterol feeding. | 1988 | Biosci. Rep. | pmid:3408811 |
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| Azrolan NI and Coleman PS | A discoordinate increase in the cellular amount of 3-hydroxy-3-methylglutaryl-CoA reductase results in the loss of rate-limiting control over cholesterogenesis in a tumour cell-free system. | 1989 | Biochem. J. | pmid:2705993 |
| Hitchcock CA et al. | Purification and properties of cytochrome P-450-dependent 14 alpha-sterol demethylase from Candida albicans. | 1989 | Biochem. J. | pmid:2556999 |
| Emmons GT et al. | 24,25-epoxysterols. Differentiation of 24R and 24S epimers by 13C nuclear magnetic resonance spectroscopy. | 1989 | J. Lipid Res. | pmid:2918248 |
| Popják G et al. | Inhibition of cholesterol synthesis and cell growth by 24(R,S),25-iminolanosterol and triparanol in cultured rat hepatoma cells. | 1989 | J. Biol. Chem. | pmid:2703486 |
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| Singh GB et al. | Hypotensive activity of 8,24-euphadien-3 beta-ol (euphol). | 1989 | Planta Med. | pmid:2616667 |
| Aoyama Y et al. | Deformylation of 32-oxo-24,25-dihydrolanosterol by the purified cytochrome P-45014DM (lanosterol 14 alpha-demethylase) from yeast evidence confirming the intermediate step of lanosterol 14 alpha-demethylation. | 1989 | J. Biol. Chem. | pmid:2509459 |
| Aoyama Y et al. | The 3-hydroxy group of lanosterol is essential for orienting the substrate site of cytochrome P-450(14DM) (lanosterol 14 alpha- demethylase). | 1989 | Biochim. Biophys. Acta | pmid:2688742 |
| Pfaller M et al. | Effects of cilofungin (LY121019) on carbohydrate and sterol composition of Candida albicans. | 1989 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:2695329 |
| Nes WD et al. | Metabolism of 24(R,S),25-epiminolanosterol to 25-aminolanosterol and lanosterol by Gibberella fujikuroi. | 1989 | Arch. Biochem. Biophys. | pmid:2751307 |
| Sonoda Y et al. | Metabolism of 24,25-dihydrolanosterol analogs by partially purified cytochrome P-450(14DM) from rat liver microsomes. | 1989 | Chem. Pharm. Bull. | pmid:2752483 |
| Aoyama Y et al. | Role of the 8-double bond of lanosterol in the enzyme-substrate interaction of cytochrome P-450(14DM) (lanosterol 14 alpha-demethylase). | 1989 | Biochim. Biophys. Acta | pmid:2917143 |
| Wang CN et al. | The aggregation of human platelet induced by ganodermic acid S. | 1989 | Biochim. Biophys. Acta | pmid:2819092 |
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| Nes WD et al. | Concerning the role of 24,25-dihydrolanosterol and lanostanol in sterol biosynthesis by cultured cells. | 1989 Mar-May | Steroids | pmid:2799854 |
| Maitra US et al. | Biosynthetic preparation of labeled 4,4-dimethylzymosterol. | 1989 Mar-May | Steroids | pmid:2799859 |
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| Howell SA and Mallet AI | A novel lanosterol isomer produced in response to azole antifungals. | 1990 | J. Steroid Biochem. | pmid:2214765 |
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| Pfaller MA et al. | Effects of terconazole and other azole antifungal agents on the sterol and carbohydrate composition of Candida albicans. | 1990 Jan-Feb | Diagn. Microbiol. Infect. Dis. | pmid:2184984 |
| Sonoda Y et al. | Synthesis of lanosterol derivatives with a functional group at C-32, including an antineoplastic sterol, 3 beta-hydroxylanost-7-en-32-oic acid. | 1991 | Chem. Pharm. Bull. | pmid:2049792 |