MeSH term | MeSH ID | Detail |
---|---|---|
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fraz S et al. | Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). | 2018 | Aquat. Toxicol. | pmid:29494825 |
Bah SY et al. | Immune oxysterols: Role in mycobacterial infection and inflammation. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27155346 |
Schöls L et al. | Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. | 2017 | Brain | pmid:29126212 |
Dang EV et al. | Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. | 2017 | Cell | pmid:29033131 |
Tricarico PM et al. | 25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway. | 2017 | Int. J. Biochem. Cell Biol. | pmid:28918367 |
Li Z et al. | Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. | 2017 | Circulation | pmid:28794002 |
Wang J et al. | Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication. | 2017 | J. Gen. Virol. | pmid:28631596 |
Olivier E et al. | 25-Hydroxycholesterol induces both P2X7-dependent pyroptosis and caspase-dependent apoptosis in human skin model: New insights into degenerative pathways. | 2017 | Chem. Phys. Lipids | pmid:28599978 |
Gregus M et al. | Non-aqueous capillary electrophoretic separation of cholesterol and 25-hydroxycholesterol after derivatization with Girard P reagent. | 2017 | Chem. Phys. Lipids | pmid:28583433 |
Cagno V et al. | Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2017 | Redox Biol | pmid:28359048 |