MeSH term | MeSH ID | Detail |
---|---|---|
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gerber R et al. | Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. | 2004 | Anal. Biochem. | pmid:15136164 |
van Lier JE et al. | Cholesterol hydroperoxides as substrates for cholesterol-metabolizing cytochrome P450 enzymes and alternative sources of 25-hydroxycholesterol and other oxysterols. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:26230055 |
Anderson DK et al. | Spinal cord injury and protection. | 1985 | Ann Emerg Med | pmid:3927795 |
Benga G et al. | A comparison of the effects of cholesterol and 25-hydroxycholesterol on egg yolk lecithin liposomes: spin label studies. | 1983 | Ann. N. Y. Acad. Sci. | pmid:6322650 |
Holmes RP et al. | The effect of membrane lipid composition on the permeability of membranes to Ca2+. | 1983 | Ann. N. Y. Acad. Sci. | pmid:6142672 |
Rao ML et al. | Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10672272 |
Bottero S et al. | In vivo and in vitro exposures of carp and carp tissues to graded concentrations of endocrine disrupting chemicals. | 2005 | Ann. N. Y. Acad. Sci. | pmid:15891032 |
Rudney H and Sexton RC | Regulation of cholesterol biosynthesis. | 1986 | Annu. Rev. Nutr. | pmid:3524618 |
Larsson O and Blegen H | Regulatory role of mevalonate in the growth of normal and neoplastic human mammary epithelial cells. | 1993 Jul-Aug | Anticancer Res. | pmid:8352528 |
Carlberg M and Larsson O | Role of N-linked glycosylation in cell-cycle progression and initiation of DNA synthesis in tumor-transformed human fibroblasts. | 1993 Jan-Feb | Anticancer Res. | pmid:8476209 |