| MeSH term | MeSH ID | Detail |
|---|---|---|
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
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| Bhushan S et al. | Uropathogenic E. coli induce different immune response in testicular and peritoneal macrophages: implications for testicular immune privilege. | 2011 | PLoS ONE | pmid:22164293 |
| Mouzat K et al. | A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia. | 2011 | BMC Med. Genet. | pmid:22029530 |
| Subathra M et al. | Sphingomyelin synthases regulate protein trafficking and secretion. | 2011 | PLoS ONE | pmid:21980337 |
| Cho SY et al. | Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. | 2011 | FEBS Lett. | pmid:21944868 |
| den Uyl D et al. | (Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis. | 2011 | Arthritis Res. Ther. | pmid:21241491 |
| Lappano R et al. | The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes. | 2011 | PLoS ONE | pmid:21304949 |
| Palozza P et al. | Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. | 2011 | J. Nutr. Biochem. | pmid:20573495 |
| Keller M et al. | Inflammatory-induced hibernation in the fetus: priming of fetal sheep metabolism correlates with developmental brain injury. | 2011 | PLoS ONE | pmid:22242129 |
| Bai Q et al. | Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells. | 2011 | Atherosclerosis | pmid:21146170 |
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| Zhong W et al. | OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. | 2011 | Exp. Cell Res. | pmid:21669198 |
| Liu C et al. | Oxysterols direct B-cell migration through EBI2. | 2011 | Nature | pmid:21796211 |
| Aye IL et al. | Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. | 2011 | Placenta | pmid:21208656 |
| Kamisuki S et al. | Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. | 2011 | J. Med. Chem. | pmid:21561152 |
| Girard E et al. | The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages. | 2011 | PLoS ONE | pmid:22205993 |
| Dasari B et al. | Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. | 2011 | BMC Ophthalmol | pmid:21851605 |
| Pachikian BD et al. | Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. | 2011 | PLoS ONE | pmid:21853118 |
| Clariana M and GarcÃa-Regueiro JA | Effect of high pressure processing on cholesterol oxidation products in vacuum packaged sliced dry-cured ham. | 2011 | Food Chem. Toxicol. | pmid:21426921 |
| Vallianou I et al. | Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. | 2011 | PLoS ONE | pmid:22073134 |
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| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Berrodin TJ et al. | Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. | 2010 | Mol. Pharmacol. | pmid:20837678 |
| Jiménez-López JM et al. | Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids. | 2010 | Lipids Health Dis | pmid:20338039 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |
| Matsui M et al. | Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter. | 2010 | Chem. Biol. | pmid:21168770 |
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| Malik AK et al. | 5-Androstene-3β,7β,17β-triol (β-AET) slows thermal injury induced osteopenia in mice: relation to aging and osteoporosis. | 2010 | PLoS ONE | pmid:21042414 |
| Furuita K et al. | Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies. | 2010 | J. Biol. Chem. | pmid:20178991 |
| Amirak E et al. | Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19958749 |
| Sharma I et al. | Role of 8-iso-prostaglandin F2alpha and 25-hydroxycholesterol in the pathophysiology of endometriosis. | 2010 | Fertil. Steril. | pmid:19324352 |
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| Rujoi M et al. | Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells. | 2010 | PLoS ONE | pmid:20877719 |
| Banerji S et al. | Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIα. | 2010 | Mol. Biol. Cell | pmid:20881054 |
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| Hess D et al. | Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. | 2010 | PLoS ONE | pmid:20613975 |
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| Schüle R et al. | Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. | 2010 | J. Lipid Res. | pmid:19812052 |
| Perales S et al. | Fish oil supplementation reverses the effect of cholesterol on apoptotic gene expression in smooth muscle cells. | 2010 | Lipids Health Dis | pmid:20630092 |
| Mintzer E et al. | Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes. | 2010 | Chem. Phys. Lipids | pmid:20471966 |
| Nunomura S et al. | Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners. | 2010 | FEBS Lett. | pmid:20138879 |
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