| MeSH term | MeSH ID | Detail |
|---|---|---|
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jiménez-López JM et al. | Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids. | 2010 | Lipids Health Dis | pmid:20338039 |
| Hartman IZ et al. | Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets. | 2010 | J. Biol. Chem. | pmid:20406816 |
| Furuita K et al. | Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies. | 2010 | J. Biol. Chem. | pmid:20178991 |
| Amirak E et al. | Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19958749 |
| Sharma I et al. | Role of 8-iso-prostaglandin F2alpha and 25-hydroxycholesterol in the pathophysiology of endometriosis. | 2010 | Fertil. Steril. | pmid:19324352 |
| Dugas B et al. | Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol. | 2010 | Eur J Nutr | pmid:20339855 |
| Wang Y et al. | A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). | 2010 | Biochim. Biophys. Acta | pmid:20211758 |
| Lee PC and DeBose-Boyd RA | Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells. | 2010 | J. Lipid Res. | pmid:19617589 |
| Jin L et al. | Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. | 2010 | Mol. Endocrinol. | pmid:20203100 |
| Ecker J et al. | Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20385828 |
| Schüle R et al. | Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. | 2010 | J. Lipid Res. | pmid:19812052 |
| Perales S et al. | Fish oil supplementation reverses the effect of cholesterol on apoptotic gene expression in smooth muscle cells. | 2010 | Lipids Health Dis | pmid:20630092 |
| Mintzer E et al. | Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes. | 2010 | Chem. Phys. Lipids | pmid:20471966 |
| Solberg R et al. | Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs. | 2010 | PLoS ONE | pmid:20231903 |
| Pezacki JP et al. | Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. | 2009 | BMC Chem Biol | pmid:19149867 |
| Palaniappan M and Menon KM | Regulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells. | 2009 | Biol. Reprod. | pmid:19299314 |
| Calleros L et al. | Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells. | 2009 | Carcinogenesis | pmid:19700418 |
| Liu R et al. | Characterization of fluorescent sterol binding to purified human NPC1. | 2009 | J. Biol. Chem. | pmid:19029290 |
| Leblond F et al. | Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19179626 |
| Yu PL et al. | Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats. | 2009 | J. Cell. Biochem. | pmid:19639602 |
| Hynynen R et al. | OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. | 2009 | J. Lipid Res. | pmid:19224871 |
| Owen DM et al. | Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor. | 2009 | Virology | pmid:19751943 |
| Li H et al. | Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine. | 2009 | J. Biol. Chem. | pmid:19687008 |
| Li T and Chiang JY | Regulation of bile acid and cholesterol metabolism by PPARs. | 2009 | PPAR Res | pmid:19636418 |
| van Deursen D et al. | Activation of hepatic lipase expression by oleic acid: possible involvement of USF1. | 2009 | Nutrients | pmid:22253973 |
| Katz R et al. | Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA). | 2009 | Diabetes | pmid:19136658 |
| Trasino SE et al. | Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. | 2009 | Mol. Cancer Ther. | pmid:19531574 |
| Chatterjee S et al. | Identification of novel genes and pathways regulating SREBP transcriptional activity. | 2009 | PLoS ONE | pmid:19381295 |
| Romanelli RJ et al. | Insulin-like growth factor-I-stimulated Akt phosphorylation and oligodendrocyte progenitor cell survival require cholesterol-enriched membranes. | 2009 | J. Neurosci. Res. | pmid:19382214 |
| Perttilä J et al. | OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. | 2009 | J. Mol. Med. | pmid:19554302 |
| RodrÃguez-Acebes S et al. | Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. | 2009 | Biochem. J. | pmid:19260826 |
| Xiong Q et al. | Cholesterol-dependent anaplasma phagocytophilum exploits the low-density lipoprotein uptake pathway. | 2009 | PLoS Pathog. | pmid:19283084 |
| Kwon HJ et al. | Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. | 2009 | Cell | pmid:19563754 |
| Slominski AT et al. | Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. | 2009 | PLoS ONE | pmid:19190754 |
| Jesch ED et al. | Sitosterol reduces messenger RNA and protein expression levels of Niemann-Pick C1-like 1 in FHs 74 Int cells. | 2009 | Nutr Res | pmid:19963159 |
| Mitomo H et al. | Oxysterol-induced rearrangement of the liquid-ordered phase: a possible link to Alzheimer's disease? | 2009 | J. Am. Chem. Soc. | pmid:19658396 |
| Ogawa S et al. | A facile synthesis of C-24 and C-25 oxysterols by in situ generated ethyl(trifluoromethyl)dioxirane. | 2009 | Steroids | pmid:18996406 |
| Lu R et al. | FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. | 2009 | J. Lipid Res. | pmid:19229075 |
| Trousson A et al. | 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR. | 2009 | J. Neurochem. | pmid:19250336 |
| Gale SE et al. | Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. | 2009 | J. Biol. Chem. | pmid:18996837 |
| Perales S et al. | Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia. | 2009 | J. Biomed. Biotechnol. | pmid:19727411 |
| Chisaki I et al. | Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver. | 2009 | Biochim. Biophys. Acta | pmid:19728987 |
| Liu J et al. | Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol. | 2009 | Arch. Biochem. Biophys. | pmid:19464253 |
| Andreone L et al. | Regulation of inhibin/activin expression in rat early antral follicles. | 2009 | Mol. Cell. Endocrinol. | pmid:19464342 |
| Ma YB et al. | [Activation of sterol regulatory element binding protein and its involvement in endothelial cell migration]. | 2009 | Zhonghua Bing Li Xue Za Zhi | pmid:19489226 |
| Diczfalusy U et al. | Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide. | 2009 | J. Lipid Res. | pmid:19502589 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Villeneuve DL et al. | Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor. | 2009 | Environ. Health Perspect. | pmid:19440503 |
| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |
| Olsen BN et al. | Perturbations of membrane structure by cholesterol and cholesterol derivatives are determined by sterol orientation. | 2009 | J. Am. Chem. Soc. | pmid:19334779 |