MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Chang TY and Limanek JS | Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells. | 1980 | J. Biol. Chem. | pmid:6105157 |
Duncan JL and Buckingham L | Resistance to streptolysin O in mammalian cells treated with oxygenated derivatives of cholesterol. Cholesterol content of resistant cells and recovery of streptolysin O sensitivity. | 1980 | Biochim. Biophys. Acta | pmid:7459354 |
Habenicht AJ et al. | Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor. | 1980 | J. Biol. Chem. | pmid:6768732 |
Alsema GJ et al. | Side chain cleavage of hydroxylated sterols by bovine adrenal cortex mitochondria: observation of 25-hydroxylase activity during incubation at pH 7.80. | 1980 | J. Steroid Biochem. | pmid:7392630 |
Erickson SK et al. | Studies on the mechanisms of the rapid modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in intact liver by mevalonolactone and 25-hydroxycholesterol. | 1980 | Biochim. Biophys. Acta | pmid:7417482 |
Drevon CA et al. | Regulation of cholesterol esterification and biosynthesis in monolayer cultures of normal adult rat hepatocytes. | 1980 | J. Biol. Chem. | pmid:7410416 |
Chan SY and Pollard M | Characterization of a very-low-density lipoprotein (VLDL)-associated cytotoxic factor. | 1981 | Br. J. Cancer | pmid:7284237 |
Gebhard RL and Prigge WF | In vivo regulation of canine intestinal 3-hydroxy-3-methylglutaryl coenzyme A reductase by cholesterol, lipoprotein, and fatty acids. | 1981 | J. Lipid Res. | pmid:7299291 |
Swell L et al. | A quantitative evaluation of the conversion of 25-hydroxycholesterol to bile acids in man. | 1981 | Biochim. Biophys. Acta | pmid:7011410 |