MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sparrow SM et al. | U18666A inhibits intracellular cholesterol transport and neurotransmitter release in human neuroblastoma cells. | 1999 | Neurochem. Res. | pmid:9973239 |
Ayala-Torres S et al. | Apoptosis induced by oxysterol in CEM cells is associated with negative regulation of c-myc. | 1999 | Exp. Cell Res. | pmid:9882528 |
Du EZ et al. | Translocation-arrested apolipoprotein B evades proteasome degradation via a sterol-sensitive block in ubiquitin conjugation. | 1999 | J. Biol. Chem. | pmid:9880570 |
Lagace TA et al. | Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. | 1999 | J. Lipid Res. | pmid:9869656 |
Holleran AL et al. | Effect of tamoxifen on cholesterol synthesis in HepG2 cells and cultured rat hepatocytes. | 1998 | Metab. Clin. Exp. | pmid:9867082 |
Moog C et al. | Oxysterols, but not cholesterol, inhibit human immunodeficiency virus replication in vitro. | 1998 | Antivir. Chem. Chemother. | pmid:9865387 |
Storey MK et al. | Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol. | 1998 | Biochem. J. | pmid:9806908 |
Christenson LK et al. | Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions. | 1998 | J. Biol. Chem. | pmid:9804848 |
Nohturfft A et al. | Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9789003 |
Kato H et al. | Macrophage inhibition of lymphocyte and tumor cell growth is mediated by 25-hydroxycholesterol in the cell membrane. | 1998 | Int. Arch. Allergy Immunol. | pmid:9751851 |