| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Medina MW et al. | Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. | 2011 | PLoS ONE | pmid:21559365 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Bhushan S et al. | Uropathogenic E. coli induce different immune response in testicular and peritoneal macrophages: implications for testicular immune privilege. | 2011 | PLoS ONE | pmid:22164293 |
| Mouzat K et al. | A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia. | 2011 | BMC Med. Genet. | pmid:22029530 |
| Subathra M et al. | Sphingomyelin synthases regulate protein trafficking and secretion. | 2011 | PLoS ONE | pmid:21980337 |
| Ebrahimi KB and Handa JT | Lipids, lipoproteins, and age-related macular degeneration. | 2011 | J Lipids | pmid:21822496 |
| Thorsell AG et al. | Comparative structural analysis of lipid binding START domains. | 2011 | PLoS ONE | pmid:21738568 |
| Rehman S et al. | Antiviral drugs against hepatitis C virus. | 2011 | Genet Vaccines Ther | pmid:21699699 |
| Zhou T et al. | OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62. | 2011 | PLoS ONE | pmid:21698267 |
| Honda A et al. | Cholesterol 25-hydroxylation activity of CYP3A. | 2011 | J. Lipid Res. | pmid:21576599 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| Shan PF et al. | Apelin attenuates the osteoblastic differentiation of vascular smooth muscle cells. | 2011 | PLoS ONE | pmid:21437254 |
| Cho SY et al. | Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. | 2011 | FEBS Lett. | pmid:21944868 |
| Palozza P et al. | Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. | 2011 | J. Nutr. Biochem. | pmid:20573495 |
| Davis W | The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells. | 2011 | Biochim. Biophys. Acta | pmid:21810484 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Kamisuki S et al. | Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. | 2011 | J. Med. Chem. | pmid:21561152 |
| Dasari B et al. | Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. | 2011 | BMC Ophthalmol | pmid:21851605 |
| Pachikian BD et al. | Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. | 2011 | PLoS ONE | pmid:21853118 |
| Clariana M and GarcÃa-Regueiro JA | Effect of high pressure processing on cholesterol oxidation products in vacuum packaged sliced dry-cured ham. | 2011 | Food Chem. Toxicol. | pmid:21426921 |
| Vallianou I et al. | Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. | 2011 | PLoS ONE | pmid:22073134 |
| Vallim T and Salter AM | Regulation of hepatic gene expression by saturated fatty acids. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20227267 |
| Aye IL et al. | Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. | 2010 | Biochim. Biophys. Acta | pmid:20570635 |
| Ullrich C et al. | Effects of cholesterol and its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices. | 2010 | Pharmacology | pmid:20571288 |
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Berrodin TJ et al. | Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. | 2010 | Mol. Pharmacol. | pmid:20837678 |
| Jiménez-López JM et al. | Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids. | 2010 | Lipids Health Dis | pmid:20338039 |
| Catalgol B and Kartal Ozer N | Lipid rafts and redox regulation of cellular signaling in cholesterol induced atherosclerosis. | 2010 | Curr Cardiol Rev | pmid:22043207 |
| Chang LL et al. | Effects and mechanisms of nonylphenol on corticosterone release in rat zona fasciculata-reticularis cells. | 2010 | Toxicol. Sci. | pmid:20837582 |
| Matsui M et al. | Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter. | 2010 | Chem. Biol. | pmid:21168770 |
| Nguyen VP et al. | 25-Hydroxycholesterol exerts both a cox-2-dependent transient proliferative effect and cox-2-independent cytotoxic effect on bovine endothelial cells in a time- and cell-type-dependent manner. | 2010 | J Angiogenes Res | pmid:21070649 |
| Malik AK et al. | 5-Androstene-3β,7β,17β-triol (β-AET) slows thermal injury induced osteopenia in mice: relation to aging and osteoporosis. | 2010 | PLoS ONE | pmid:21042414 |
| Shoemaker JE et al. | Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk. | 2010 | BMC Syst Biol | pmid:20579396 |
| Menon KM et al. | Molecular regulation of gonadotropin receptor expression: relationship to sterol metabolism. | 2010 | Mol. Cell. Endocrinol. | pmid:20570710 |
| Borthwick F et al. | Overexpression of STARD3 in human monocyte/macrophages induces an anti-atherogenic lipid phenotype. | 2010 | Clin. Sci. | pmid:20491656 |
| Hartman IZ et al. | Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets. | 2010 | J. Biol. Chem. | pmid:20406816 |
| Dugas B et al. | Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol. | 2010 | Eur J Nutr | pmid:20339855 |
| Kobuna H et al. | Multivesicular body formation requires OSBP-related proteins and cholesterol. | 2010 | PLoS Genet. | pmid:20700434 |
| Xu L et al. | Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate. | 2010 | Lipids | pmid:20700770 |
| Heretsch P et al. | Modulators of the hedgehog signaling pathway. | 2010 | Bioorg. Med. Chem. | pmid:20708941 |
| Tao JL et al. | Lipids-induced apoptosis is aggravated by acyl-coenzyme A: cholesterol acyltransferase inhibitor. | 2010 | Chin. Med. Sci. J. | pmid:20598228 |
| McDonald JG and Russell DW | Editorial: 25-Hydroxycholesterol: a new life in immunology. | 2010 | J. Leukoc. Biol. | pmid:21123296 |
| Rujoi M et al. | Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells. | 2010 | PLoS ONE | pmid:20877719 |
| Banerji S et al. | Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIα. | 2010 | Mol. Biol. Cell | pmid:20881054 |
| Plasen D et al. | Initial response of endothelial cells to acute stimulation with a lipid component: increase cyclooxygenase activity by induction of COX-2 through activation of tyrosine kinase. | 2010 | J Med Assoc Thai | pmid:21299081 |
| Ando H et al. | Low-density lipoprotein and oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase in vitro. | 2010 | Biochim. Biophys. Acta | pmid:20045741 |
| Hess D et al. | Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. | 2010 | PLoS ONE | pmid:20613975 |
| Hu J et al. | Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. | 2010 | Nutr Metab (Lond) | pmid:20515451 |
| Ruchala P et al. | Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids. | 2010 | PLoS ONE | pmid:20418958 |
| Ishii H et al. | Analysis of the 22-NBD-cholesterol transfer between liposome membranes and its relation to the intermembrane exchange of 25-hydroxycholesterol. | 2010 | Colloids Surf B Biointerfaces | pmid:20122819 |