| MeSH term | MeSH ID | Detail |
|---|---|---|
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rosklint T et al. | Oxysterols induce interleukin-1beta production in human macrophages. | 2002 | Eur. J. Clin. Invest. | pmid:11851725 |
| Cusinato F and Bruni A | Selective effect of cholesterylphosphoserine on intracellular cholesterol transport. | 2002 | Lipids | pmid:11876263 |
| Yee WL et al. | Green tea catechins decrease apolipoprotein B-100 secretion from HepG2 cells. | 2002 | Mol. Cell. Biochem. | pmid:11936850 |
| Chen JJ et al. | 25-hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro. | 2002 | Biol. Reprod. | pmid:11967195 |
| Agellon LB et al. | Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice. | 2002 | J. Biol. Chem. | pmid:11967256 |
| Javitt NB | Cholesterol, hydroxycholesterols, and bile acids. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11969205 |
| Javitt NB | 25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles. | 2002 | J. Lipid Res. | pmid:11971935 |
| Tomoyori H et al. | Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036056 |
| Ghelli A et al. | 7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells. | 2002 | Arch. Biochem. Biophys. | pmid:12051665 |
| Jung D et al. | Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. | 2002 | Gastroenterology | pmid:12055601 |
| Kim JW et al. | Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro. | 2002 | Exp. Mol. Med. | pmid:12085989 |
| Vilchis F et al. | The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus). | 2002 | Gen. Comp. Endocrinol. | pmid:12093115 |
| Zhang L et al. | Characterization of the estrogenic response to genistein in Japanese medaka (Oryzias latipes). | 2002 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:12106897 |
| Gregorio-King CC et al. | Effect of oxysterols on hematopoietic progenitor cells. | 2002 | Exp. Hematol. | pmid:12135663 |
| Chiao YC et al. | Inhibition of testosterone production by propylthiouracil in rat Leydig cells. | 2002 | Biol. Reprod. | pmid:12135875 |
| Nakahara M et al. | Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA. | 2002 | J. Biol. Chem. | pmid:12149270 |
| Brown AJ et al. | Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. | 2002 | Mol. Cell | pmid:12191470 |
| Ando M et al. | Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis. | 2002 | Br. J. Nutr. | pmid:12323083 |
| Ropero S et al. | Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes. | 2003 | Cell. Signal. | pmid:12401528 |
| Meaney S et al. | On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. | 2002 | J. Lipid Res. | pmid:12454275 |