| MeSH term | MeSH ID | Detail |
|---|---|---|
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Berrodin TJ et al. | Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. | 2010 | Mol. Pharmacol. | pmid:20837678 |
| Matsui M et al. | Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter. | 2010 | Chem. Biol. | pmid:21168770 |
| Nguyen VP et al. | 25-Hydroxycholesterol exerts both a cox-2-dependent transient proliferative effect and cox-2-independent cytotoxic effect on bovine endothelial cells in a time- and cell-type-dependent manner. | 2010 | J Angiogenes Res | pmid:21070649 |
| Malik AK et al. | 5-Androstene-3β,7β,17β-triol (β-AET) slows thermal injury induced osteopenia in mice: relation to aging and osteoporosis. | 2010 | PLoS ONE | pmid:21042414 |
| Kobuna H et al. | Multivesicular body formation requires OSBP-related proteins and cholesterol. | 2010 | PLoS Genet. | pmid:20700434 |
| Xu L et al. | Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate. | 2010 | Lipids | pmid:20700770 |
| Heretsch P et al. | Modulators of the hedgehog signaling pathway. | 2010 | Bioorg. Med. Chem. | pmid:20708941 |
| McDonald JG and Russell DW | Editorial: 25-Hydroxycholesterol: a new life in immunology. | 2010 | J. Leukoc. Biol. | pmid:21123296 |
| Rujoi M et al. | Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells. | 2010 | PLoS ONE | pmid:20877719 |
| Banerji S et al. | Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIα. | 2010 | Mol. Biol. Cell | pmid:20881054 |
| Plasen D et al. | Initial response of endothelial cells to acute stimulation with a lipid component: increase cyclooxygenase activity by induction of COX-2 through activation of tyrosine kinase. | 2010 | J Med Assoc Thai | pmid:21299081 |
| Hess D et al. | Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. | 2010 | PLoS ONE | pmid:20613975 |
| Stottrup BL et al. | Taking another look with fluorescence microscopy: image processing techniques in Langmuir monolayers for the twenty-first century. | 2010 | Biochim. Biophys. Acta | pmid:20067758 |
| Pezacki JP et al. | Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. | 2009 | BMC Chem Biol | pmid:19149867 |
| Calleros L et al. | Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells. | 2009 | Carcinogenesis | pmid:19700418 |
| Liu R et al. | Characterization of fluorescent sterol binding to purified human NPC1. | 2009 | J. Biol. Chem. | pmid:19029290 |
| Leblond F et al. | Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19179626 |
| Yu PL et al. | Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats. | 2009 | J. Cell. Biochem. | pmid:19639602 |
| Owen DM et al. | Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor. | 2009 | Virology | pmid:19751943 |
| Li H et al. | Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine. | 2009 | J. Biol. Chem. | pmid:19687008 |
| Li T and Chiang JY | Regulation of bile acid and cholesterol metabolism by PPARs. | 2009 | PPAR Res | pmid:19636418 |
| van Deursen D et al. | Activation of hepatic lipase expression by oleic acid: possible involvement of USF1. | 2009 | Nutrients | pmid:22253973 |
| Katz R et al. | Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA). | 2009 | Diabetes | pmid:19136658 |
| Trasino SE et al. | Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. | 2009 | Mol. Cancer Ther. | pmid:19531574 |
| Chatterjee S et al. | Identification of novel genes and pathways regulating SREBP transcriptional activity. | 2009 | PLoS ONE | pmid:19381295 |
| Romanelli RJ et al. | Insulin-like growth factor-I-stimulated Akt phosphorylation and oligodendrocyte progenitor cell survival require cholesterol-enriched membranes. | 2009 | J. Neurosci. Res. | pmid:19382214 |
| Trousson A et al. | Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death. | 2009 | PLoS ONE | pmid:19956653 |
| Perttilä J et al. | OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. | 2009 | J. Mol. Med. | pmid:19554302 |
| Kwon HJ et al. | Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. | 2009 | Cell | pmid:19563754 |
| Slominski AT et al. | Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. | 2009 | PLoS ONE | pmid:19190754 |
| Jesch ED et al. | Sitosterol reduces messenger RNA and protein expression levels of Niemann-Pick C1-like 1 in FHs 74 Int cells. | 2009 | Nutr Res | pmid:19963159 |
| Mitomo H et al. | Oxysterol-induced rearrangement of the liquid-ordered phase: a possible link to Alzheimer's disease? | 2009 | J. Am. Chem. Soc. | pmid:19658396 |
| Ogawa S et al. | A facile synthesis of C-24 and C-25 oxysterols by in situ generated ethyl(trifluoromethyl)dioxirane. | 2009 | Steroids | pmid:18996406 |
| Lu R et al. | FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. | 2009 | J. Lipid Res. | pmid:19229075 |
| Trousson A et al. | 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR. | 2009 | J. Neurochem. | pmid:19250336 |
| Gale SE et al. | Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. | 2009 | J. Biol. Chem. | pmid:18996837 |
| Lemaire-Ewing S et al. | 7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent. | 2009 | Cell Biol. Toxicol. | pmid:18317936 |
| Perales S et al. | Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia. | 2009 | J. Biomed. Biotechnol. | pmid:19727411 |
| Chisaki I et al. | Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver. | 2009 | Biochim. Biophys. Acta | pmid:19728987 |
| Liu J et al. | Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol. | 2009 | Arch. Biochem. Biophys. | pmid:19464253 |
| Andreone L et al. | Regulation of inhibin/activin expression in rat early antral follicles. | 2009 | Mol. Cell. Endocrinol. | pmid:19464342 |
| Ma YB et al. | [Activation of sterol regulatory element binding protein and its involvement in endothelial cell migration]. | 2009 | Zhonghua Bing Li Xue Za Zhi | pmid:19489226 |
| Diczfalusy U et al. | Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide. | 2009 | J. Lipid Res. | pmid:19502589 |
| Bauman DR et al. | 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805370 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Krycer JR et al. | Cholesterol homeostasis in two commonly used human prostate cancer cell-lines, LNCaP and PC-3. | 2009 | PLoS ONE | pmid:20041144 |
| Villeneuve DL et al. | Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor. | 2009 | Environ. Health Perspect. | pmid:19440503 |
| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |
| Olsen BN et al. | Perturbations of membrane structure by cholesterol and cholesterol derivatives are determined by sterol orientation. | 2009 | J. Am. Chem. Soc. | pmid:19334779 |