MeSH term | MeSH ID | Detail |
---|---|---|
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yoshikawa T et al. | Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. | 2001 | Mol. Cell. Biol. | pmid:11287605 |
Rose K et al. | Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation. | 2001 | J. Biol. Chem. | pmid:11290741 |
Zhang Z et al. | Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. | 2001 | J. Lipid Res. | pmid:11290837 |
Seo T et al. | Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells. | 2001 | Biochemistry | pmid:11294643 |
Chen JJ et al. | Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells. | 2001 | Br. J. Pharmacol. | pmid:11309248 |
Tamasawa N et al. | An oxidized derivative of cholesterol increases the release of soluble vascular cell adhesion molecule-1 from human umbilical vein endothelial cells in culture. | 2001 | Biochim. Biophys. Acta | pmid:11325610 |
Miszkiel G and Kotwica J | Mechanism of action of noradrenaline on secretion of progesterone and oxytocin by the bovine corpus luteum in vitro. | 2001 | Acta Vet. Hung. | pmid:11402689 |
Sekar N and Veldhuis JD | Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways. | 2001 | Endocrinology | pmid:11416012 |
Awad AB et al. | Plant sterols regulate rat vascular smooth muscle cell growth and prostacyclin release in culture. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11427042 |
Elsegood CL et al. | Binding and uptake of chylomicron remnants by primary and THP-1 human monocyte-derived macrophages: determination of binding proteins. | 2001 | Clin. Sci. | pmid:11473484 |