| MeSH term | MeSH ID | Detail |
|---|---|---|
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tsai SC et al. | Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells. | 2003 | J. Cell. Biochem. | pmid:14635199 |
| Leusch FD and MacLatchy DL | In vivo implants of beta-sitosterol cause reductions of reactive cholesterol pools in mitochondria isolated from gonads of male goldfish (Carassius auratus). | 2003 | Gen. Comp. Endocrinol. | pmid:14636632 |
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Ropero S et al. | Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes. | 2003 | Cell. Signal. | pmid:12401528 |
| Xia H and Redman CM | Oxysterols suppress constitutive fibrinogen expression. | 2003 | Thromb. Haemost. | pmid:12876624 |
| Augustowska K et al. | Effects of dioxin (2,3,7,8-TCDD) and PCDDs/PCDFs congeners mixture on steroidogenesis in human placenta tissue culture. | 2003 | Endocr Regul | pmid:12916318 |
| Lim HK et al. | Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line. | 2003 | Life Sci. | pmid:12527036 |
| Ong JM et al. | Oxysterol-induced toxicity in R28 and ARPE-19 cells. | 2003 | Neurochem. Res. | pmid:12718442 |
| Bitsch F et al. | Identification of natural ligands of retinoic acid receptor-related orphan receptor alpha ligand-binding domain expressed in Sf9 cells--a mass spectrometry approach. | 2003 | Anal. Biochem. | pmid:14622968 |
| Miura S et al. | Sterol-mediated regulation of hormone-sensitive lipase in 3T3-L1 adipocytes. | 2003 | Lipids | pmid:14506837 |
| Yoshida T et al. | Origin of oxysterols in hepatic bile of patients with biliary infection. | 2003 | Am. J. Gastroenterol. | pmid:14572579 |
| Ourlin JC et al. | A Link between cholesterol levels and phenobarbital induction of cytochromes P450. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11846416 |
| Rosklint T et al. | Oxysterols induce interleukin-1beta production in human macrophages. | 2002 | Eur. J. Clin. Invest. | pmid:11851725 |
| Hayden JM et al. | Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. | 2002 | J. Lipid Res. | pmid:11792719 |
| Chiao YC et al. | Inhibition of testosterone production by propylthiouracil in rat Leydig cells. | 2002 | Biol. Reprod. | pmid:12135875 |
| Javitt NB | 25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles. | 2002 | J. Lipid Res. | pmid:11971935 |
| Chen JJ et al. | 25-hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro. | 2002 | Biol. Reprod. | pmid:11967195 |
| Zhang L et al. | Characterization of the estrogenic response to genistein in Japanese medaka (Oryzias latipes). | 2002 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:12106897 |
| Kim JW et al. | Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro. | 2002 | Exp. Mol. Med. | pmid:12085989 |
| Tomoyori H et al. | Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036056 |
| Ghelli A et al. | 7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells. | 2002 | Arch. Biochem. Biophys. | pmid:12051665 |
| Meaney S et al. | On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. | 2002 | J. Lipid Res. | pmid:12454275 |
| Agellon LB et al. | Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice. | 2002 | J. Biol. Chem. | pmid:11967256 |
| Wassmann S et al. | Cellular antioxidant effects of atorvastatin in vitro and in vivo. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:11834532 |
| Gregorio-King CC et al. | Effect of oxysterols on hematopoietic progenitor cells. | 2002 | Exp. Hematol. | pmid:12135663 |
| Yee WL et al. | Green tea catechins decrease apolipoprotein B-100 secretion from HepG2 cells. | 2002 | Mol. Cell. Biochem. | pmid:11936850 |
| Nakahara M et al. | Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA. | 2002 | J. Biol. Chem. | pmid:12149270 |
| Jostarndt K et al. | Dissociation of apoptosis induction and CD36 upregulation by enzymatically modified low-density lipoprotein in monocytic cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11798172 |
| Jung D et al. | Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. | 2002 | Gastroenterology | pmid:12055601 |
| Brown AJ et al. | Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. | 2002 | Mol. Cell | pmid:12191470 |
| Cusinato F and Bruni A | Selective effect of cholesterylphosphoserine on intracellular cholesterol transport. | 2002 | Lipids | pmid:11876263 |
| Ando M et al. | Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis. | 2002 | Br. J. Nutr. | pmid:12323083 |
| Vilchis F et al. | The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus). | 2002 | Gen. Comp. Endocrinol. | pmid:12093115 |
| Lee JS et al. | The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells. | 2002 | BMC Complement Altern Med | pmid:12485466 |
| Wang C et al. | Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments. | 2002 | Biochem. J. | pmid:11802775 |
| Javitt NB | Cholesterol, hydroxycholesterols, and bile acids. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11969205 |
| Tsuruoka H et al. | Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements. | 2002 | J. Biol. Chem. | pmid:11707442 |
| Yoshikawa T et al. | Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. | 2001 | Mol. Cell. Biol. | pmid:11287605 |
| O'Callaghan YC et al. | Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. | 2001 | Cell Biol. Toxicol. | pmid:11499696 |
| Englund MC et al. | 25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages. | 2001 | Atherosclerosis | pmid:11500175 |
| Gueguen Y et al. | Control of apolipoprotein E secretion by 25-hydroxycholesterol and proinflammatory cytokines in the human astrocytoma cell line CCF-STTG1. | 2001 | Cell Biol. Toxicol. | pmid:11693580 |
| Tamasawa N et al. | An oxidized derivative of cholesterol increases the release of soluble vascular cell adhesion molecule-1 from human umbilical vein endothelial cells in culture. | 2001 | Biochim. Biophys. Acta | pmid:11325610 |
| Martin C et al. | cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate. | 2001 | Biochem. J. | pmid:11284740 |
| Sugawara T et al. | Molecular cloning and structural analysis of human sterol C5 desaturase. | 2001 | Biochim. Biophys. Acta | pmid:11731337 |
| Phillips JE et al. | 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells. | 2001 | Atherosclerosis | pmid:11689214 |
| Feng Y et al. | Inhibition of the mitogen activated protein kinase, p38 alpha, prevents proinflammatory cytokine induction by human adherent mononuclear leukocytes in response to lipid loading. | 2001 | Atherosclerosis | pmid:11583711 |
| Miszkiel G and Kotwica J | Mechanism of action of noradrenaline on secretion of progesterone and oxytocin by the bovine corpus luteum in vitro. | 2001 | Acta Vet. Hung. | pmid:11402689 |
| Sekar N and Veldhuis JD | Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways. | 2001 | Endocrinology | pmid:11416012 |
| Warren JT et al. | Woc (without children) gene control of ecdysone biosynthesis in Drosophila melanogaster. | 2001 | Mol. Cell. Endocrinol. | pmid:11476936 |
| Awad AB et al. | Plant sterols regulate rat vascular smooth muscle cell growth and prostacyclin release in culture. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11427042 |