| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhao Q et al. | Investigation on the synthesis of 25-hydroxycholesterol. | 2014 | Steroids | pmid:24582707 |
| Westover EJ and Covey DF | Synthesis of ent-25-hydroxycholesterol. | 2006 | Steroids | pmid:16519912 |
| Lu H et al. | Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis. | 2015 | Steroids | pmid:25759117 |
| Wilson WK et al. | Inhibitors of sterol synthesis. Effects of fluorine substitution at carbon atom 25 of cholesterol on its spectral and chromatographic properties and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells. | 1994 | Steroids | pmid:8073444 |
| Ogawa S et al. | A facile synthesis of C-24 and C-25 oxysterols by in situ generated ethyl(trifluoromethyl)dioxirane. | 2009 | Steroids | pmid:18996406 |
| Barnaba C et al. | Cholesterol photo-oxidation: A chemical reaction network for kinetic modeling. | 2016 | Steroids | pmid:27756542 |
| Li D and Spencer TA | Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. | 2000 | Steroids | pmid:10978732 |
| Rajkumar K et al. | Effect of lipoproteins and luteotrophins on progesterone accumulation by luteal cells from the pregnant pig. | 1985 | Steroids | pmid:4089914 |
| Xia H and Redman CM | Oxysterols suppress constitutive fibrinogen expression. | 2003 | Thromb. Haemost. | pmid:12876624 |
| Guan JZ et al. | Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. | 2003 | Tohoku J. Exp. Med. | pmid:14690017 |
| Latif R et al. | Steroidogenesis in amlodipine treated purified Leydig cells. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22032983 |
| Kocarek TA et al. | Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes. | 1993 | Toxicol. Appl. Pharmacol. | pmid:8511800 |
| Nishigori M et al. | Highly potent binding and inverse agonist activity of bisphenol A derivatives for retinoid-related orphan nuclear receptor RORγ. | 2012 | Toxicol. Lett. | pmid:22659100 |
| Chang LL et al. | Effects and mechanisms of nonylphenol on corticosterone release in rat zona fasciculata-reticularis cells. | 2010 | Toxicol. Sci. | pmid:20837582 |
| Marinovich M et al. | Effect of 25-hydroxycholesterol, 26-hydroxycholesterol and its analogue, 26-aminocholesterol, on protein content, protein synthesis and LDH leakage in mouse epidermal cells. | 1995 | Toxicology | pmid:7761997 |
| Charman M et al. | Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1. | 2017 | Traffic | pmid:28471037 |
| Spangrude GJ et al. | Inhibitory effects of various oxygenated sterols on the differentiation and function of tumor-specific cytotoxic T lymphocytes. | 1982 | Transplantation | pmid:6979815 |
| Song Z et al. | Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection. | 2017 | Vet. Microbiol. | pmid:29103685 |
| Guo J et al. | HCV NS5A and NS5B enhance expression of human ceramide glucosyltransferase gene. | 2012 | Virol Sin | pmid:22270805 |
| Owen DM et al. | Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor. | 2009 | Virology | pmid:19751943 |
| Tachibana Y | [Synthesis and structure-activity relationships of bioactive compounds using sterols]. | 2006 | Yakugaku Zasshi | pmid:17077615 |
| Ma YB et al. | [Activation of sterol regulatory element binding protein and its involvement in endothelial cell migration]. | 2009 | Zhonghua Bing Li Xue Za Zhi | pmid:19489226 |
| Vanderhyden BC | Oocyte-secreted factors regulate granulosa cell steroidogenesis. | 1996 | Zygote | pmid:9153773 |