| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Houten SM et al. | Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients. | 2003 | J. Biol. Chem. | pmid:12477733 |
| Lee JS et al. | The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells. | 2002 | BMC Complement Altern Med | pmid:12485466 |
| Lim HK et al. | Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line. | 2003 | Life Sci. | pmid:12527036 |
| Fowler AJ et al. | Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. | 2003 | J. Invest. Dermatol. | pmid:12542530 |
| Ruan XZ et al. | PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. | 2003 | J. Am. Soc. Nephrol. | pmid:12595494 |
| Carsia RV and John-Alder H | Seasonal alterations in adrenocortical cell function associated with stress-responsiveness and sex in the eastern fence lizard (Sceloporus undulatus). | 2003 | Horm Behav | pmid:12695115 |
| Ong JM et al. | Oxysterol-induced toxicity in R28 and ARPE-19 cells. | 2003 | Neurochem. Res. | pmid:12718442 |
| Frolov A et al. | NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. | 2003 | J. Biol. Chem. | pmid:12719428 |
| Norlin M et al. | On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. | 2003 | J. Lipid Res. | pmid:12777473 |
| O'Sullivan AJ et al. | Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: modulatory effects of alpha- and gamma-tocopherol. | 2003 May-Jun | J Appl Toxicol | pmid:12794941 |
| Kaul D and Anand PK | Regulation of PPAR-gamma gene in human promyelocytic HL-60 cell line. | 2003 | Leuk. Res. | pmid:12801525 |
| Xia H and Redman CM | Oxysterols suppress constitutive fibrinogen expression. | 2003 | Thromb. Haemost. | pmid:12876624 |
| Antonio V et al. | Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. | 2003 | Biochem. J. | pmid:12882648 |
| Augustowska K et al. | Effects of dioxin (2,3,7,8-TCDD) and PCDDs/PCDFs congeners mixture on steroidogenesis in human placenta tissue culture. | 2003 | Endocr Regul | pmid:12916318 |
| Chen JJ et al. | Direct effect of propylthiouracil on progesterone release in rat granulosa cells. | 2003 | Br. J. Pharmacol. | pmid:12922945 |
| Rosignoli C et al. | Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo. | 2003 | Exp. Dermatol. | pmid:12930306 |
| Dashti N | The effect of low density lipoproteins, cholesterol, and 25-hydroxycholesterol on apolipoprotein B gene expression in HepG2 cells. | 1992 | J. Biol. Chem. | pmid:1313035 |
| Tam SP and Ramharack R | The effect of 25-hydroxycholesterol on the regulation of apolipoprotein E mRNA levels and secretion in the human hepatoma HepG2. | 1992 | Atherosclerosis | pmid:1329783 |
| Taylor FR | Correlation among oxysterol potencies in the regulation of the degradation of 3-hydroxy-3-methylglutaryl CoA reductase, the repression of 3-hydroxy-3-methylglutaryl CoA synthase and affinities for the oxysterol receptor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1352965 |
| Hwang PL | Inhibitors of protein and RNA synthesis block the cytotoxic effects of oxygenated sterols. | 1992 | Biochim. Biophys. Acta | pmid:1379472 |
| Chase DJ et al. | Maintenance or stimulation of steroidogenic enzymes and testosterone production in rat Leydig cells by continuous and pulsatile infusions of luteinizing hormone during passive immunization against gonadotrophin-releasing hormone. | 1992 | J. Reprod. Fertil. | pmid:1404082 |
| Kawamura K and Kummerow FA | Effect of 25-hydroxycholesterol on cytotoxicity and prostacyclin production in cultured human umbilical arterial endothelial cells. | 1992 | Eicosanoids | pmid:1419077 |
| Dueland S et al. | Expression of 7 alpha-hydroxylase in non-hepatic cells results in liver phenotypic resistance of the low density lipoprotein receptor to cholesterol repression. | 1992 | J. Biol. Chem. | pmid:1429619 |
| Miura S et al. | Sterol-mediated regulation of hormone-sensitive lipase in 3T3-L1 adipocytes. | 2003 | Lipids | pmid:14506837 |
| Girão H et al. | 7-ketocholesterol stimulates differentiation of lens epithelial cells. | 2003 | Mol. Vis. | pmid:14551533 |
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Rusiñol AE et al. | AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis. | 2004 | J. Biol. Chem. | pmid:14559920 |
| Yoshida T et al. | Origin of oxysterols in hepatic bile of patients with biliary infection. | 2003 | Am. J. Gastroenterol. | pmid:14572579 |
| Roitelman J and Simoni RD | Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. | 1992 | J. Biol. Chem. | pmid:1460026 |
| Rydberg EK et al. | Hypoxia increases 25-hydroxycholesterol-induced interleukin-8 protein secretion in human macrophages. | 2003 | Atherosclerosis | pmid:14612204 |
| Christenson LK and Devoto L | Cholesterol transport and steroidogenesis by the corpus luteum. | 2003 | Reprod. Biol. Endocrinol. | pmid:14613534 |
| Chang LL et al. | Effects of dehydroepiandrosterone on corticosterone release in rat zona fasciculata-reticularis cells. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:14615881 |
| Bitsch F et al. | Identification of natural ligands of retinoic acid receptor-related orphan receptor alpha ligand-binding domain expressed in Sf9 cells--a mass spectrometry approach. | 2003 | Anal. Biochem. | pmid:14622968 |
| Roitelman J et al. | Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity. | 2004 | J. Biol. Chem. | pmid:14627708 |
| Tsai SC et al. | Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells. | 2003 | J. Cell. Biochem. | pmid:14635199 |
| Leusch FD and MacLatchy DL | In vivo implants of beta-sitosterol cause reductions of reactive cholesterol pools in mitochondria isolated from gonads of male goldfish (Carassius auratus). | 2003 | Gen. Comp. Endocrinol. | pmid:14636632 |
| Wenz JJ and Barrantes FJ | Steroid structural requirements for stabilizing or disrupting lipid domains. | 2003 | Biochemistry | pmid:14640695 |
| Girão H et al. | Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases. | 2003 | Exp. Cell Res. | pmid:14644170 |
| Stone BG and Evans CD | Evidence for a common biliary cholesterol and VLDL cholesterol precursor pool in rat liver. | 1992 | J. Lipid Res. | pmid:1464750 |
| Guan JZ et al. | Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. | 2003 | Tohoku J. Exp. Med. | pmid:14690017 |
| Yu-Poth S et al. | Conjugated linoleic acid upregulates LDL receptor gene expression in HepG2 cells. | 2004 | J. Nutr. | pmid:14704295 |
| Shenoy SD et al. | CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. | 2004 | Drug Metab. Dispos. | pmid:14709622 |
| Gbaguidi GF and Agellon LB | The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer. | 2004 | Nucleic Acids Res. | pmid:14960721 |
| Yu L et al. | Sterol regulation of scavenger receptor class B type I in macrophages. | 2004 | J. Lipid Res. | pmid:14967816 |
| Ripollés Piquer B et al. | Effect of LPS on basal and induced apo E secretion by 25-OH chol and 9cRA in differentiated CaCo-2. | 2004 | J. Cell. Biochem. | pmid:14991770 |
| Huang SH et al. | Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes. | 2004 | J. Cell. Biochem. | pmid:15034936 |
| Desaint S et al. | NFY interacts with the promoter region of two genes involved in the rat peroxisomal fatty acid beta-oxidation: the multifunctional protein type 1 and the 3-ketoacyl-CoA B thiolase. | 2004 | Lipids Health Dis | pmid:15046640 |
| King SR et al. | Oxysterols regulate expression of the steroidogenic acute regulatory protein. | 2004 | J. Mol. Endocrinol. | pmid:15072555 |
| Le Jossic-Corcos C et al. | Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15084352 |
| Dorset DL | Binary phase behavior of angiotoxic oxidized cholesterols with cholesterol. | 1992 | Biochim. Biophys. Acta | pmid:1511006 |