MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Warren JT et al. | Woc (without children) gene control of ecdysone biosynthesis in Drosophila melanogaster. | 2001 | Mol. Cell. Endocrinol. | pmid:11476936 |
O'Callaghan YC et al. | Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. | 2001 | Cell Biol. Toxicol. | pmid:11499696 |
Englund MC et al. | 25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages. | 2001 | Atherosclerosis | pmid:11500175 |
Janowski BA et al. | The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. | 2001 | J. Biol. Chem. | pmid:11577112 |
Leventhal AR et al. | Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux. | 2001 | J. Biol. Chem. | pmid:11579092 |
Feng Y et al. | Inhibition of the mitogen activated protein kinase, p38 alpha, prevents proinflammatory cytokine induction by human adherent mononuclear leukocytes in response to lipid loading. | 2001 | Atherosclerosis | pmid:11583711 |
Panini SR et al. | Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol. | 2001 | J. Lipid Res. | pmid:11590225 |
Field FJ et al. | Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells. | 2001 | J. Lipid Res. | pmid:11590226 |
Phillips JE et al. | 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells. | 2001 | Atherosclerosis | pmid:11689214 |
Gueguen Y et al. | Control of apolipoprotein E secretion by 25-hydroxycholesterol and proinflammatory cytokines in the human astrocytoma cell line CCF-STTG1. | 2001 | Cell Biol. Toxicol. | pmid:11693580 |