MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhou Q and Kummerow FA | The influence of 25-hydroxycholesterol on phosphatidylinositol content in cultured smooth muscle cells. | 1994 | Proc. Soc. Exp. Biol. Med. | pmid:8208734 |
Kim I and Greenwald GS | Steroidogenic effects of lipoproteins and 25-hydroxycholesterol on luteal and ovarian cells: a comparison of two pseudopregnant rat models. | 1986 | Proc. Soc. Exp. Biol. Med. | pmid:3945632 |
Peng SK et al. | Influence of cholesterol oxidation derivatives on membrane bound enzymes in cultured aortic smooth muscle cells. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:2994076 |
Carsia RV et al. | Ontogenic corticosteroidogenesis of the domestic fowl: response of isolated adrenocortical cells. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3031690 |
Carsia RV et al. | Effect of 3,3'-iminodiproprionitrile (IDPN) on corticosteroidogenesis of isolated adrenocortical cells. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3031691 |
Vallim T and Salter AM | Regulation of hepatic gene expression by saturated fatty acids. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20227267 |
Awad AB et al. | Plant sterols regulate rat vascular smooth muscle cell growth and prostacyclin release in culture. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11427042 |
Dushkin M et al. | Effects of oxysterols upon macrophage and lymphocyte functions in vitro. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9644113 |
Zerbinati C et al. | Mass spectrometry profiling of oxysterols in human sperm identifies 25-hydroxycholesterol as a marker of sperm function. | 2017 | Redox Biol | pmid:27912195 |
Cagno V et al. | Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2017 | Redox Biol | pmid:28359048 |