MeSH term | MeSH ID | Detail |
---|---|---|
Atherosclerosis | D050197 | 85 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Atherosclerosis | D050197 | 85 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Matsuda H et al. | Regulation of rat hepatic α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase, a key enzyme in the tryptophan- NAD pathway, by dietary cholesterol and sterol regulatory element-binding protein-2. | 2014 | Eur J Nutr | pmid:25289390 |
Lathe R et al. | Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature. | 2014 | BMC Geriatr | pmid:24656052 |
Zhong W et al. | OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. | 2014 | Exp. Cell Res. | pmid:24424245 |
Ren S and Ning Y | Sulfation of 25-hydroxycholesterol regulates lipid metabolism, inflammatory responses, and cell proliferation. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24302009 |
Jiang W et al. | Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis. | 2014 | PLoS ONE | pmid:25426949 |
Larkin JC et al. | The influence of ligand-activated LXR on primary human trophoblasts. | 2014 | Placenta | pmid:25255963 |
Casella C et al. | Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells. | 2014 | Gynecol. Oncol. | pmid:25134999 |
Ren S et al. | Identification of novel regulatory cholesterol metabolite, 5-cholesten, 3β,25-diol, disulfate. | 2014 | PLoS ONE | pmid:25072708 |
Sekiya M et al. | Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages. | 2014 | J. Lipid Res. | pmid:24891333 |
Linsenbardt AJ et al. | Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. | 2014 | Neuropharmacology | pmid:24878244 |