| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Kisseleva AF et al. | Distribution of exogenous 25-hydroxycholesterol in Hep G2 cells between two different pools. | 1999 | FEBS Lett. | pmid:10100635 |
| Dushkin MI et al. | [Effects of hydroxysterols on expression of inflammatory cytokine genes and their level in macrophages tolerant to endotoxin]. | 1999 | Biull Eksp Biol Med | pmid:10190010 |
| Rodway MR et al. | Regulation of steroidogenesis in jc-410, a stable cell line of porcine granulosa origin. | 1999 | Mol. Cell. Endocrinol. | pmid:10221774 |
| McCluskey S et al. | Alpha-tocopherol inhibits oxidative stress induced by cholestanetriol and 25-hydroxycholesterol in porcine ovarian granulosa cells. | 1999 | Mol. Cell. Biochem. | pmid:10391143 |
| Gauthier B et al. | Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1. | 1999 | J. Lipid Res. | pmid:10393213 |
| Rodway MR et al. | Steroid regulation of progesterone synthesis in a stable porcine granulosa cell line: a role for progestins. | 1999 | J. Steroid Biochem. Mol. Biol. | pmid:10416831 |
| Aikawa K et al. | Inhibition of cholesteryl ester formation in macrophages by azole antimycotics. | 1999 | Biochem. Pharmacol. | pmid:10424763 |
| Yokoyama S et al. | Suppression of rat liver tumorigenesis by 25-hydroxycholesterol and all-trans retinoic acid: differentiation therapy for hepatocellular carcinoma. | 1999 | Int. J. Oncol. | pmid:10427141 |
| Espenshade PJ et al. | Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. | 1999 | J. Biol. Chem. | pmid:10428864 |
| Cheng D et al. | Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins. | 1999 | J. Biol. Chem. | pmid:10428865 |
| Kreklau EL et al. | Nitric oxide inhibits human aldosteronogenesis without guanylyl cyclase stimulation. | 1999 | Mol. Cell. Endocrinol. | pmid:10459858 |
| Ravid T et al. | Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation in lovastatin-resistant cells. | 1999 | J. Biol. Chem. | pmid:10506194 |
| Parish EJ et al. | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by side-chain oxysterols and their derivatives. | 1999 | Crit. Rev. Biochem. Mol. Biol. | pmid:10517646 |
| Brown A et al. | Manipulation of cholesterol and cholesteryl ester synthesis has multiple effects on the metabolism of apolipoprotein B and the secretion of very-low-density lipoprotein by primary hepatocyte cultures. | 1999 | Biochim. Biophys. Acta | pmid:10521709 |
| Jang MK et al. | Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10558912 |
| Plemenitas A and Watson JA | Down-regulation of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with highly purified liposomal cholesterol. | 1999 | Eur. J. Biochem. | pmid:10561571 |
| Lange Y et al. | Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol. | 1999 | J. Lipid Res. | pmid:10588952 |
| Wohlfeil ER and Campbell WB | 25-hydroxycholesterol increases eicosanoids and alters morphology in cultured pulmonary artery smooth muscle and endothelial cells. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10591667 |
| Rao ML et al. | Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10672272 |
| Hanley K et al. | Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. | 2000 | J. Invest. Dermatol. | pmid:10692116 |
| Mailhot G et al. | Influence of the in vivo calcium status on cellular calcium homeostasis and the level of the calcium-binding protein calreticulin in rat hepatocytes. | 2000 | Endocrinology | pmid:10698163 |
| Nes WD et al. | Identification of the lipophilic factor produced by macrophages that stimulates steroidogenesis. | 2000 | Endocrinology | pmid:10698170 |
| Rusiñol AE et al. | Isolation of a somatic cell mutant resistant to the induction of apoptosis by oxidized low density lipoprotein. | 2000 | J. Biol. Chem. | pmid:10702300 |
| Choi JW and Choi HS | The regulatory effects of thyroid hormone on the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 2000 | Endocr. Res. | pmid:10711719 |
| Dushkin MI et al. | [Effect of 25-hydroxycholesterol and progesterone on esterification of cholesterol, viscosity, and protein-lipid interactions in macrophage membranes]. | 2000 | Biull Eksp Biol Med | pmid:10732231 |
| Flach J et al. | The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733934 |
| Li-Hawkins J et al. | Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. | 2000 | J. Biol. Chem. | pmid:10748047 |
| Ridgway ND | Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin. | 2000 | Biochim. Biophys. Acta | pmid:10760463 |
| Duan H et al. | Sterols and inhibitors of sterol transport modulate the degradation and secretion of macrophage ApoE: requirement for the C-terminal domain. | 2000 | Biochim. Biophys. Acta | pmid:10760464 |
| Yokoyama S et al. | Anti-tumor effects of 25-hydroxycholesterol and low-dose recombinant tumor necrosis factor-alpha on rat liver tumorigenesis: modulated differentiation therapy for hepatocellular carcinoma. | 2000 | Int. J. Oncol. | pmid:10762641 |
| O'Callaghan YC et al. | Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations. | 1999 | Eur J Nutr | pmid:10784381 |
| O'Brien NM et al. | Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals. | 2000 | Biochem. Soc. Trans. | pmid:10816093 |
| Norlin M et al. | Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A). | 2000 | J. Biol. Chem. | pmid:10882719 |
| Chiao YC et al. | Direct effects of propylthiouracil on testosterone secretion in rat testicular interstitial cells. | 2000 | Br. J. Pharmacol. | pmid:10928947 |
| Spitsen GM et al. | In nonhepatic cells, cholesterol 7alpha-hydroxylase induces the expression of genes regulating cholesterol biosynthesis, efflux, and homeostasis. | 2000 | J. Lipid Res. | pmid:10946023 |
| Ravid T et al. | The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2000 | J. Biol. Chem. | pmid:10964918 |
| Mascaró C et al. | Contribution of steroidogenic factor 1 to the regulation of cholesterol synthesis. | 2000 | Biochem. J. | pmid:10970793 |
| Li D and Spencer TA | Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. | 2000 | Steroids | pmid:10978732 |
| Matsumoto K et al. | Effects of hypoxia on cholesterol metabolism in human monocyte-derived macrophages. | 2000 | Life Sci. | pmid:11057758 |
| Yang L and Sinensky MS | 25-Hydroxycholesterol activates a cytochrome c release-mediated caspase cascade. | 2000 | Biochem. Biophys. Res. Commun. | pmid:11095949 |
| Russell DW | Oxysterol biosynthetic enzymes. | 2000 | Biochim. Biophys. Acta | pmid:11111082 |
| Bourdon E et al. | Involvement of oxysterols and lysophosphatidylcholine in the oxidized LDL-induced impairment of serum albumin synthesis by HEPG2 cells. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11116066 |
| Bae S et al. | Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions. | 2001 | Biochem. J. | pmid:11171067 |
| Lee T and Chau L | Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11171590 |
| DeBose-Boyd RA et al. | Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11171976 |
| Brahimi F et al. | Control of apolipoprotein E secretion in the human hepatoma cell line KYN-2. | 2001 | Cell Biochem. Funct. | pmid:11223871 |
| Yasunobu Y et al. | Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols. | 2001 | Atherosclerosis | pmid:11254916 |
| Xu Y et al. | Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. | 2001 | J. Biol. Chem. | pmid:11279184 |
| Martin C et al. | cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate. | 2001 | Biochem. J. | pmid:11284740 |