25-Hydroxycholesterol

25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 25-Hydroxycholesterol?

25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Atherosclerosis D050197 85 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with 25-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:

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What functions are associated with 25-Hydroxycholesterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 25-Hydroxycholesterol?

Knock-out

Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 25-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
Tatidis L and Vitols S Growth modulation of low density lipoprotein receptor sterol sensitivity in cultured human fibroblasts. 2001 Lipids pmid:11795856
Yoshikawa T et al. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. 2001 Mol. Cell. Biol. pmid:11287605
O'Callaghan YC et al. Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. 2001 Cell Biol. Toxicol. pmid:11499696
Englund MC et al. 25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages. 2001 Atherosclerosis pmid:11500175
Seo T et al. Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells. 2001 Biochemistry pmid:11294643
Martin C et al. cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate. 2001 Biochem. J. pmid:11284740
Sugawara T et al. Molecular cloning and structural analysis of human sterol C5 desaturase. 2001 Biochim. Biophys. Acta pmid:11731337
Phillips JE et al. 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells. 2001 Atherosclerosis pmid:11689214
Field FJ et al. Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells. 2001 J. Lipid Res. pmid:11590226
Yasunobu Y et al. Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols. 2001 Atherosclerosis pmid:11254916
Feng Y et al. Inhibition of the mitogen activated protein kinase, p38 alpha, prevents proinflammatory cytokine induction by human adherent mononuclear leukocytes in response to lipid loading. 2001 Atherosclerosis pmid:11583711
Miszkiel G and Kotwica J Mechanism of action of noradrenaline on secretion of progesterone and oxytocin by the bovine corpus luteum in vitro. 2001 Acta Vet. Hung. pmid:11402689
DeBose-Boyd RA et al. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11171976
Sekar N and Veldhuis JD Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways. 2001 Endocrinology pmid:11416012
Brahimi F et al. Control of apolipoprotein E secretion in the human hepatoma cell line KYN-2. 2001 Cell Biochem. Funct. pmid:11223871
Warren JT et al. Woc (without children) gene control of ecdysone biosynthesis in Drosophila melanogaster. 2001 Mol. Cell. Endocrinol. pmid:11476936
Awad AB et al. Plant sterols regulate rat vascular smooth muscle cell growth and prostacyclin release in culture. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11427042
Takeuchi K et al. Adrenodoxin-cytochrome P450scc interaction as revealed by EPR spectroscopy: comparison with the putidaredoxin-cytochrome P450cam system. 2001 J. Biochem. pmid:11726279
Ravid T et al. The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 2000 J. Biol. Chem. pmid:10964918
Spitsen GM et al. In nonhepatic cells, cholesterol 7alpha-hydroxylase induces the expression of genes regulating cholesterol biosynthesis, efflux, and homeostasis. 2000 J. Lipid Res. pmid:10946023
Duan H et al. Sterols and inhibitors of sterol transport modulate the degradation and secretion of macrophage ApoE: requirement for the C-terminal domain. 2000 Biochim. Biophys. Acta pmid:10760464
Yokoyama S et al. Anti-tumor effects of 25-hydroxycholesterol and low-dose recombinant tumor necrosis factor-alpha on rat liver tumorigenesis: modulated differentiation therapy for hepatocellular carcinoma. 2000 Int. J. Oncol. pmid:10762641
Russell DW Oxysterol biosynthetic enzymes. 2000 Biochim. Biophys. Acta pmid:11111082
Bourdon E et al. Involvement of oxysterols and lysophosphatidylcholine in the oxidized LDL-induced impairment of serum albumin synthesis by HEPG2 cells. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:11116066
Yang L and Sinensky MS 25-Hydroxycholesterol activates a cytochrome c release-mediated caspase cascade. 2000 Biochem. Biophys. Res. Commun. pmid:11095949
Norlin M et al. Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A). 2000 J. Biol. Chem. pmid:10882719
Chiao YC et al. Direct effects of propylthiouracil on testosterone secretion in rat testicular interstitial cells. 2000 Br. J. Pharmacol. pmid:10928947
Li-Hawkins J et al. Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. 2000 J. Biol. Chem. pmid:10748047
Mailhot G et al. Influence of the in vivo calcium status on cellular calcium homeostasis and the level of the calcium-binding protein calreticulin in rat hepatocytes. 2000 Endocrinology pmid:10698163
Nes WD et al. Identification of the lipophilic factor produced by macrophages that stimulates steroidogenesis. 2000 Endocrinology pmid:10698170
Ridgway ND Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin. 2000 Biochim. Biophys. Acta pmid:10760463
Rusiñol AE et al. Isolation of a somatic cell mutant resistant to the induction of apoptosis by oxidized low density lipoprotein. 2000 J. Biol. Chem. pmid:10702300
Choi JW and Choi HS The regulatory effects of thyroid hormone on the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 2000 Endocr. Res. pmid:10711719
Hanley K et al. Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. 2000 J. Invest. Dermatol. pmid:10692116
Dushkin MI et al. [Effect of 25-hydroxycholesterol and progesterone on esterification of cholesterol, viscosity, and protein-lipid interactions in macrophage membranes]. 2000 Biull Eksp Biol Med pmid:10732231
O'Brien NM et al. Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals. 2000 Biochem. Soc. Trans. pmid:10816093
Flach J et al. The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. 2000 Biochem. Biophys. Res. Commun. pmid:10733934
Li D and Spencer TA Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. 2000 Steroids pmid:10978732
Mascaró C et al. Contribution of steroidogenic factor 1 to the regulation of cholesterol synthesis. 2000 Biochem. J. pmid:10970793
Matsumoto K et al. Effects of hypoxia on cholesterol metabolism in human monocyte-derived macrophages. 2000 Life Sci. pmid:11057758
Brown A et al. Manipulation of cholesterol and cholesteryl ester synthesis has multiple effects on the metabolism of apolipoprotein B and the secretion of very-low-density lipoprotein by primary hepatocyte cultures. 1999 Biochim. Biophys. Acta pmid:10521709
McCluskey S et al. Alpha-tocopherol inhibits oxidative stress induced by cholestanetriol and 25-hydroxycholesterol in porcine ovarian granulosa cells. 1999 Mol. Cell. Biochem. pmid:10391143
Du EZ et al. Translocation-arrested apolipoprotein B evades proteasome degradation via a sterol-sensitive block in ubiquitin conjugation. 1999 J. Biol. Chem. pmid:9880570
Ayala-Torres S et al. Apoptosis induced by oxysterol in CEM cells is associated with negative regulation of c-myc. 1999 Exp. Cell Res. pmid:9882528
Jang MK et al. Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. 1999 Biochem. Biophys. Res. Commun. pmid:10558912
O'Callaghan YC et al. Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations. 1999 Eur J Nutr pmid:10784381
Lagace TA et al. Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. 1999 J. Lipid Res. pmid:9869656
Kreklau EL et al. Nitric oxide inhibits human aldosteronogenesis without guanylyl cyclase stimulation. 1999 Mol. Cell. Endocrinol. pmid:10459858
Rao ML et al. Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides. 1999 Ann. N. Y. Acad. Sci. pmid:10672272
Yokoyama S et al. Suppression of rat liver tumorigenesis by 25-hydroxycholesterol and all-trans retinoic acid: differentiation therapy for hepatocellular carcinoma. 1999 Int. J. Oncol. pmid:10427141