| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang J et al. | Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase. | 1997 | Biochim. Biophys. Acta | pmid:9059514 |
| Ares MP et al. | Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells. | 1997 | J. Lipid Res. | pmid:9374127 |
| Phelan KD and Mahler HR | Acute exposure to 25-hydroxy-cholesterol selectively reduces GABAb and not GABAa receptor-mediated synaptic inhibition. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9266831 |
| Harada K et al. | Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway. | 1997 | FEBS Lett. | pmid:9247143 |
| Zhang J et al. | 7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes. | 1997 | Eur. J. Biochem. | pmid:9249018 |
| Chiloeches A et al. | Effect of mevalonate availability on the association of G-protein alpha-subunits with the plasma membrane in GH4C1 cells. | 1997 | FEBS Lett. | pmid:9003808 |
| Peffley DM and Gayen AK | Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. | 1997 | Arch. Biochem. Biophys. | pmid:9016820 |
| Lagace TA et al. | Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain. | 1997 | Biochem. J. | pmid:9337870 |
| Baum CL et al. | Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion. | 1997 | J. Biol. Chem. | pmid:9045674 |
| Zhang J et al. | Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. | 1997 | Biochem. J. | pmid:9078259 |
| Lehmann JM et al. | Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. | 1997 | J. Biol. Chem. | pmid:9013544 |
| Bhuvaneswaran C et al. | Activation of acyl-CoA: cholesterol acyltransferase in rat liver microsomes by 25-hydroxycholesterol. | 1997 | Biochem. Pharmacol. | pmid:8960060 |
| Miura S et al. | Cholesterol-mediated changes of neutral cholesterol esterase activity in macrophages. Mechanism for mobilization of cholesteryl esters in lipid droplets by HDL. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409290 |
| Musatov MI et al. | [Effect of oxidized cholesterol derivatives on lymphokine stimulated differentiation of macrophages and primary allogenic mixed human lymphocyte culture]. | 1997 | Biull Eksp Biol Med | pmid:9483320 |
| Chang JY et al. | Establishment of two morphologically distinct PC12 cell lines resistant to 25-OH-cholesterol toxicity. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9344846 |
| Duan H et al. | Degradation of macrophage ApoE in a nonlysosomal compartment. Regulation by sterols. | 1997 | J. Biol. Chem. | pmid:9388269 |
| Chang JY and Liu LZ | 25-Hydroxycholesterol causes death but does not prevent nerve growth factor-induced neurite outgrowth in PC12 cells. | 1997 | Neurochem. Int. | pmid:9308000 |
| Warren JT and Gilbert LI | Metabolism in vitro of cholesterol and 25-hydroxycholesterol by the larval prothoracic glands of Manduca sexta. | 1996 Sep-Oct | Insect Biochem. Mol. Biol. | pmid:9014337 |
| Bowling N et al. | LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins. | 1996 | J. Lipid Res. | pmid:9017510 |
| Hultén LM et al. | Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages. | 1996 | J. Clin. Invest. | pmid:8567968 |
| Berkhout TA et al. | The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1996 | J. Biol. Chem. | pmid:8662919 |
| Graham A et al. | Cholesterol esterification is not essential for secretion of lipoprotein components by HepG2 cells. | 1996 | Biochim. Biophys. Acta | pmid:8695654 |
| Verhagen JC et al. | Physical effects of biologically formed cholesterol oxidation products on lipid membranes investigated with fluorescence depolarization spectroscopy and electron spin resonance. | 1996 | J. Lipid Res. | pmid:8827521 |
| Aupeix K et al. | Oyxsterols induce membrane procoagulant activity in monocytic THP-1 cells. | 1996 | Biochem. J. | pmid:8615754 |
| Liza M et al. | Application of 2-hydroxypropyl-beta-cyclodextrin in the assay of acyl-CoA:cholesterol acyltransferase and neutral and acid cholesterol ester hydrolases. | 1996 | Lipids | pmid:8900462 |
| Spicer LJ et al. | Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis. | 1996 | J. Endocrinol. | pmid:8994382 |
| Nohturfft A et al. | Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8942999 |
| Doris PA et al. | Ouabain production by cultured adrenal cells. | 1996 | Endocrinology | pmid:8593799 |
| Carlberg M and Larsson O | Stimulatory effect of PDGF on HMG-CoA reductase activity and N-linked glycosylation contributes to increased expression of IGF-1 receptors in human fibroblasts. | 1996 | Exp. Cell Res. | pmid:8635486 |
| Palladini G et al. | Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635497 |
| Palladini G et al. | Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635498 |
| Chen H et al. | Depletion and repopulation of Leydig cells in the testes of aging brown Norway rats. | 1996 | Endocrinology | pmid:8754773 |
| Jepson CA et al. | Down-regulation of hormone-sensitive lipase in sterol ester-laden J774.2 macrophages. | 1996 | Biochem. J. | pmid:8761468 |
| Musanti R et al. | Inhibition of acyl-CoA: cholesterol acyltransferase decreases apolipoprotein B-100-containing lipoprotein secretion from HepG2 cells. | 1996 | J. Lipid Res. | pmid:8820097 |
| Lin CY and Morel DW | Esterification of oxysterols in human serum: effects on distribution and cellular uptake. | 1996 | J. Lipid Res. | pmid:8820112 |
| Graham A et al. | Impaired mobilisation of cholesterol from stored cholesteryl esters in human (THP-1) macrophages. | 1996 | Atherosclerosis | pmid:8645354 |
| Nishio E and Watanabe Y | Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8831713 |
| McGee TP et al. | Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis. | 1996 | J. Biol. Chem. | pmid:8810339 |
| Monier S et al. | Oligomerization of VIP21-caveolin in vitro is stabilized by long chain fatty acylation or cholesterol. | 1996 | FEBS Lett. | pmid:8690074 |
| Richardson MA et al. | Human liposarcoma cell line, SW872, secretes cholesteryl ester transfer protein in response to cholesterol. | 1996 | J. Lipid Res. | pmid:8725167 |
| Kawabe Y et al. | Regulation of fatty acid synthase expression by cholesterol in human cultured cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8605019 |
| Morel DW et al. | Comparison of the intracellular metabolism and trafficking of 25-hydroxycholesterol and cholesterol in macrophages. | 1996 | J. Lipid Res. | pmid:8895069 |
| Taniguchi S et al. | Dehydroepiandrosterone markedly inhibits the accumulation of cholesteryl ester in mouse macrophage J774-1 cells. | 1996 | Atherosclerosis | pmid:8879442 |
| Vanderhyden BC | Oocyte-secreted factors regulate granulosa cell steroidogenesis. | 1996 | Zygote | pmid:9153773 |
| Pak YK | Serum response element-like sequences of the human low density lipoprotein receptor promoter: possible regulation sites for sterol-independent transcriptional activation. | 1996 | Biochem. Mol. Biol. Int. | pmid:8932516 |
| Cerda SR et al. | Regulation of cholesterol synthesis in four colonic adenocarcinoma cell lines. | 1995 | Lipids | pmid:8614298 |
| Sekler MS and Simoni RD | Mutation in the lumenal part of the membrane domain of HMG-CoA reductase alters its regulated degradation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7818519 |
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| Carlson JC et al. | Stimulation of progesterone secretion in dispersed cells of rat corpora lutea by antioxidants. | 1995 | Steroids | pmid:7792831 |
| Kawabe Y et al. | The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7887956 |