| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Georgiou M et al. | Steroid synthesis-dependent, oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures. | 1987 | Endocrinology | pmid:2820696 |
| Golos TG and Strauss JF | Regulation of low density lipoprotein receptor gene expression in cultured human granulosa cells: roles of human chorionic gonadotropin, 8-bromo-3',5'-cyclic adenosine monophosphate, and protein synthesis. | 1987 | Mol. Endocrinol. | pmid:2840565 |
| Jingami H et al. | Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum. | 1987 | J. Cell Biol. | pmid:3584246 |
| Beseme F et al. | Rat liver cytosol oxysterol-binding protein. Characterization and comparison with the HTC cell protein. | 1987 | FEBS Lett. | pmid:3803583 |
| Bagavandoss P and Midgley AR | Lack of difference between retinoic acid and retinol in stimulating progesterone production by luteinizing granulosa cells in vitro. | 1987 | Endocrinology | pmid:3036474 |
| Hasumi K et al. | Overaccumulation of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase in a compactin(ML-236B)-resistant mouse cell line with defects in the regulation of its activity. | 1987 | Eur. J. Biochem. | pmid:3569277 |
| Rajkumar K et al. | In vitro binding and utilization of lipoproteins by luteal cells from ferrets treated with dopaminergic drugs during pseudopregnancy. | 1987 | Gen. Comp. Endocrinol. | pmid:3666406 |
| Larsson O and Johansson BM | Mevalonic acid products as mediators of cell proliferation in simian virus 40-transformed 3T3 cells. | 1987 | Cancer Res. | pmid:3040232 |
| Tomita K et al. | Chinese hamster ovary cell mutant with defective down-regulation of low density lipoprotein receptors. | 1987 | J. Biol. Chem. | pmid:3805025 |
| Liscum L and Faust JR | Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts. | 1987 | J. Biol. Chem. | pmid:3680287 |
| Wong GA et al. | Acetoacetyl-CoA ligase activity in the isolated rat hepatocyte: effects of 25-hydroxycholesterol and high density lipoprotein. | 1987 | Biosci. Rep. | pmid:3663886 |
| Mazzone T et al. | Macrophage free cholesterol content regulates apolipoprotein E synthesis. | 1987 | J. Biol. Chem. | pmid:3624230 |
| Faust J and Krieger M | Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant. | 1987 | J. Biol. Chem. | pmid:3643925 |
| Sampson WJ et al. | The role of acyl-CoA: cholesterol acyltransferase in the metabolism of free cholesterol to cholesteryl esters or bile acids in primary cultures of rat hepatocytes. | 1987 | Biochim. Biophys. Acta | pmid:3593752 |
| Südhof TC et al. | 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. | 1987 | Cell | pmid:3030558 |
| Carsia RV et al. | Ontogenic corticosteroidogenesis of the domestic fowl: response of isolated adrenocortical cells. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3031690 |
| Bruneau C et al. | Influence of lipid environment on insulin binding in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552053 |
| Carsia RV et al. | Effect of 3,3'-iminodiproprionitrile (IDPN) on corticosteroidogenesis of isolated adrenocortical cells. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3031691 |
| Bruneau C et al. | Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552054 |
| Lambeth JD et al. | Cholesterol sulfate inhibits adrenal mitochondrial cholesterol side chain cleavage at a site distinct from cytochrome P-450scc. Evidence for an intramitochondrial cholesterol translocator. | 1987 | J. Biol. Chem. | pmid:3597410 |
| Hotta M and Baird A | The inhibition of low density lipoprotein metabolism by transforming growth factor-beta mediates its effects on steroidogenesis in bovine adrenocortical cells in vitro. | 1987 | Endocrinology | pmid:3036466 |
| St Clair RW et al. | Metabolism of low density lipoproteins by pigeon skin fibroblasts and aortic smooth muscle cells. Comparison of cells from atherosclerosis-susceptible and atherosclerosis-resistant pigeons. | 1986 Mar-Apr | Arteriosclerosis | pmid:3954671 |
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| Veldhuis JD et al. | Synergistic actions of estradiol and the insulin-like growth factor somatomedin-C on swine ovarian (granulosa) cells. | 1986 | Endocrinology | pmid:3732135 |
| Golos TG et al. | Expression of low density lipoprotein receptor in cultured human granulosa cells: regulation by human chorionic gonadotropin, cyclic AMP, and sterol. | 1986 | J. Lipid Res. | pmid:3794551 |
| Richert L et al. | Inhibition of IL-2 secretion and IL-2 receptor appearance of activated lymphocytes pretreated with hydroxylated sterols. | 1986 | Immunol. Lett. | pmid:3096880 |
| Filipovic I and Buddecke E | Calcium channel blockers stimulate LDL receptor synthesis in human skin fibroblasts. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3718500 |
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| Kliman HJ et al. | Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. | 1986 | Endocrinology | pmid:3512258 |
| Kim I and Greenwald GS | Steroidogenic effects of lipoproteins and 25-hydroxycholesterol on luteal and ovarian cells: a comparison of two pseudopregnant rat models. | 1986 | Proc. Soc. Exp. Biol. Med. | pmid:3945632 |
| Besème F et al. | Characterization of oxysterol-binding protein in rat embryo fibroblasts and variations as a function of the cell cycle. | 1986 | Biochim. Biophys. Acta | pmid:3955082 |
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| Filipovic I and Buddecke E | Calmodulin antagonists stimulate LDL receptor synthesis in human skin fibroblasts. | 1986 | Biochim. Biophys. Acta | pmid:2418882 |
| Tanaka RD et al. | Inhibition of lysosomal protein degradation inhibits the basal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1986 | J. Lipid Res. | pmid:3016130 |
| Saucier SE et al. | Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts. | 1985 | J. Biol. Chem. | pmid:4055791 |
| Stone BG et al. | Regulation of rat biliary cholesterol secretion by agents that alter intrahepatic cholesterol metabolism. Evidence for a distinct biliary precursor pool. | 1985 | J. Clin. Invest. | pmid:4056052 |
| Lino J et al. | Multihormone regulation of steroidogenesis in cultured porcine granulosa cells: studies in serum-free medium. | 1985 | Endocrinology | pmid:3922742 |
| Boissonneault GA and Heiniger HJ | 25-Hydroxycholesterol-induced elevations in 45Ca uptake: permeability changes in P815 cells. | 1985 | J. Cell. Physiol. | pmid:3934181 |
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| Georgiou M and Payne AH | 25-Hydroxycholesterol-supported and 8-bromo-adenosine 3',5'-monophosphate-stimulated testosterone production by primary cultures of two populations of rat Leydig cells. | 1985 | Endocrinology | pmid:4017960 |
| Peffley D and Sinensky M | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis by a non-sterol mevalonate-derived product in Mev-1 cells. Apparent translational control. | 1985 | J. Biol. Chem. | pmid:4019518 |
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| Gebhard RL et al. | 3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in the human gastrointestinal tract. | 1985 | J. Lipid Res. | pmid:3973513 |
| Peng SK et al. | Influence of cholesterol oxidation derivatives on membrane bound enzymes in cultured aortic smooth muscle cells. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:2994076 |