| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kaur M et al. | Receptor-Ck-dependent regulation of genes involved in the cell cycle. | 1998 | Mol. Cell. Biochem. | pmid:9562250 |
| Chang JY et al. | Neurotoxicity of 25-OH-cholesterol on sympathetic neurons. | 1998 | Brain Res. Bull. | pmid:9566506 |
| Lin HS et al. | Synthesis of 4 alpha-(2-propenyl)-5,6-secocholestan-3 alpha-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4 alpha-(2-propenyl)-5 alpha-cholestan-3 alpha-ol. | 1998 | Steroids | pmid:9589554 |
| Chang JY and Liu LZ | Neurotoxicity of cholesterol oxides on cultured cerebellar granule cells. | 1998 | Neurochem. Int. | pmid:9596554 |
| Grøndahl C et al. | Meiosis-activating sterol promotes resumption of meiosis in mouse oocytes cultured in vitro in contrast to related oxysterols. | 1998 | Biol. Reprod. | pmid:9603267 |
| Mellon SH and Bair SR | 25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor-1 (SF-1). | 1998 | Endocrinology | pmid:9607816 |
| Bucci C et al. | Free fatty acids modulate LDL receptor activity in BHK-21 cells. | 1998 | Atherosclerosis | pmid:9622276 |
| Rosenfeld JM and Osborne TF | HLH106, a Drosophila sterol regulatory element-binding protein in a natural cholesterol auxotroph. | 1998 | J. Biol. Chem. | pmid:9632664 |
| Dushkin M et al. | Effects of oxysterols upon macrophage and lymphocyte functions in vitro. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9644113 |
| Stengel D et al. | Inhibition of LPL expression in human monocyte-derived macrophages is dependent on LDL oxidation state: a key role for lysophosphatidylcholine. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9672079 |
| Fu Q et al. | Control of cholesterol biosynthesis in Schwann cells. | 1998 | J. Neurochem. | pmid:9681444 |
| Thewke DP et al. | Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins. | 1998 | J. Biol. Chem. | pmid:9694903 |
| Chang JY et al. | Cholesterol oxides induce programmed cell death in microglial cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9731219 |
| Kato H et al. | Macrophage inhibition of lymphocyte and tumor cell growth is mediated by 25-hydroxycholesterol in the cell membrane. | 1998 | Int. Arch. Allergy Immunol. | pmid:9751851 |
| Nohturfft A et al. | Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9789003 |
| Christenson LK et al. | Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions. | 1998 | J. Biol. Chem. | pmid:9804848 |
| Storey MK et al. | Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol. | 1998 | Biochem. J. | pmid:9806908 |
| Moog C et al. | Oxysterols, but not cholesterol, inhibit human immunodeficiency virus replication in vitro. | 1998 | Antivir. Chem. Chemother. | pmid:9865387 |
| Holleran AL et al. | Effect of tamoxifen on cholesterol synthesis in HepG2 cells and cultured rat hepatocytes. | 1998 | Metab. Clin. Exp. | pmid:9867082 |
| Lagace TA et al. | Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. | 1999 | J. Lipid Res. | pmid:9869656 |
| Du EZ et al. | Translocation-arrested apolipoprotein B evades proteasome degradation via a sterol-sensitive block in ubiquitin conjugation. | 1999 | J. Biol. Chem. | pmid:9880570 |
| Ayala-Torres S et al. | Apoptosis induced by oxysterol in CEM cells is associated with negative regulation of c-myc. | 1999 | Exp. Cell Res. | pmid:9882528 |
| Sparrow SM et al. | U18666A inhibits intracellular cholesterol transport and neurotransmitter release in human neuroblastoma cells. | 1999 | Neurochem. Res. | pmid:9973239 |