| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Richert L et al. | Inhibition of IL-2 secretion and IL-2 receptor appearance of activated lymphocytes pretreated with hydroxylated sterols. | 1986 | Immunol. Lett. | pmid:3096880 |
| St Clair RW et al. | Metabolism of low density lipoproteins by pigeon skin fibroblasts and aortic smooth muscle cells. Comparison of cells from atherosclerosis-susceptible and atherosclerosis-resistant pigeons. | 1986 Mar-Apr | Arteriosclerosis | pmid:3954671 |
| Georgiou M et al. | Steroid synthesis-dependent, oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures. | 1987 | Endocrinology | pmid:2820696 |
| Golos TG and Strauss JF | Regulation of low density lipoprotein receptor gene expression in cultured human granulosa cells: roles of human chorionic gonadotropin, 8-bromo-3',5'-cyclic adenosine monophosphate, and protein synthesis. | 1987 | Mol. Endocrinol. | pmid:2840565 |
| Jingami H et al. | Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum. | 1987 | J. Cell Biol. | pmid:3584246 |
| Beseme F et al. | Rat liver cytosol oxysterol-binding protein. Characterization and comparison with the HTC cell protein. | 1987 | FEBS Lett. | pmid:3803583 |
| Bagavandoss P and Midgley AR | Lack of difference between retinoic acid and retinol in stimulating progesterone production by luteinizing granulosa cells in vitro. | 1987 | Endocrinology | pmid:3036474 |
| Hasumi K et al. | Overaccumulation of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase in a compactin(ML-236B)-resistant mouse cell line with defects in the regulation of its activity. | 1987 | Eur. J. Biochem. | pmid:3569277 |
| Rajkumar K et al. | In vitro binding and utilization of lipoproteins by luteal cells from ferrets treated with dopaminergic drugs during pseudopregnancy. | 1987 | Gen. Comp. Endocrinol. | pmid:3666406 |
| Themmen AP et al. | Comparison of the cellular composition and steroidogenic properties of preparations of interstitial cells isolated from immature and mature rat testis. | 1987 | J. Endocrinol. | pmid:3559448 |
| Larsson O and Johansson BM | Mevalonic acid products as mediators of cell proliferation in simian virus 40-transformed 3T3 cells. | 1987 | Cancer Res. | pmid:3040232 |
| Tomita K et al. | Chinese hamster ovary cell mutant with defective down-regulation of low density lipoprotein receptors. | 1987 | J. Biol. Chem. | pmid:3805025 |
| Liscum L and Faust JR | Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts. | 1987 | J. Biol. Chem. | pmid:3680287 |
| Wong GA et al. | Acetoacetyl-CoA ligase activity in the isolated rat hepatocyte: effects of 25-hydroxycholesterol and high density lipoprotein. | 1987 | Biosci. Rep. | pmid:3663886 |
| Mazzone T et al. | Macrophage free cholesterol content regulates apolipoprotein E synthesis. | 1987 | J. Biol. Chem. | pmid:3624230 |
| Faust J and Krieger M | Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant. | 1987 | J. Biol. Chem. | pmid:3643925 |
| Sampson WJ et al. | The role of acyl-CoA: cholesterol acyltransferase in the metabolism of free cholesterol to cholesteryl esters or bile acids in primary cultures of rat hepatocytes. | 1987 | Biochim. Biophys. Acta | pmid:3593752 |
| Südhof TC et al. | 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. | 1987 | Cell | pmid:3030558 |
| Carsia RV et al. | Ontogenic corticosteroidogenesis of the domestic fowl: response of isolated adrenocortical cells. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3031690 |
| Bruneau C et al. | Influence of lipid environment on insulin binding in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552053 |
| Carsia RV et al. | Effect of 3,3'-iminodiproprionitrile (IDPN) on corticosteroidogenesis of isolated adrenocortical cells. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3031691 |
| Bruneau C et al. | Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552054 |
| Lambeth JD et al. | Cholesterol sulfate inhibits adrenal mitochondrial cholesterol side chain cleavage at a site distinct from cytochrome P-450scc. Evidence for an intramitochondrial cholesterol translocator. | 1987 | J. Biol. Chem. | pmid:3597410 |
| Hotta M and Baird A | The inhibition of low density lipoprotein metabolism by transforming growth factor-beta mediates its effects on steroidogenesis in bovine adrenocortical cells in vitro. | 1987 | Endocrinology | pmid:3036466 |
| Huijmans JG et al. | Effect of 25-hydroxy-cholesterol on the uptake of corticosterone in isolated rat liver cells. | 1988 | Horm. Metab. Res. | pmid:3371854 |
| Peffley D et al. | Further characterization of a somatic cell mutant defective in regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1988 | Somat. Cell Mol. Genet. | pmid:2904178 |
| Epand RF and Epand RM | 25-Hydroxycholesterol promotes myelin basic protein-induced leakage of phospholipid vesicles. | 1988 | Biochim. Biophys. Acta | pmid:2449243 |
| Doyle JW and Kandutsch AA | Requirement for mevalonate in cycling cells: quantitative and temporal aspects. | 1988 | J. Cell. Physiol. | pmid:3170653 |
| Rustan AC et al. | Eicosapentaenoic acid inhibits cholesterol esterification in cultured parenchymal cells and isolated microsomes from rat liver. | 1988 | J. Biol. Chem. | pmid:2836412 |
| Cox DC et al. | Effects of cholesterol and 25-hydroxycholesterol on smooth muscle cell and endothelial cell growth. | 1988 | Lipids | pmid:3367702 |
| Carsia RV et al. | Protein malnutrition in the domestic fowl induces alterations in adrenocortical function. | 1988 | Endocrinology | pmid:2828009 |
| Lahoua Z et al. | Serum-induced arachidonic acid release and prostaglandin biosynthesis are potentiated by oxygenated sterols in NRK 49F cells. | 1988 | Biochim. Biophys. Acta | pmid:3124881 |
| de la Llosa-Hermier MP et al. | Lack of short-term modulation of in vitro placental progesterone secretion in sheep. | 1988 Nov-Dec | Placenta | pmid:3070536 |
| Panini SR et al. | Sterol-independent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by mevalonate in Chinese hamster ovary cells. Magnitude and specificity. | 1989 | J. Biol. Chem. | pmid:2567731 |
| Carlson TL and Kottke BA | Effect of 25-hydroxycholesterol and bile acids on the regulation of cholesterol metabolism in Hep G2 cells. | 1989 | Biochem. J. | pmid:2513806 |
| Hayashi K et al. | Chicken oocytes and fibroblasts express different apolipoproteins-B-specific receptors. | 1989 | J. Biol. Chem. | pmid:2914946 |
| Metherall JE et al. | Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells. | 1989 | J. Biol. Chem. | pmid:2570073 |
| Morin RJ and Peng SK | Effects of cholesterol oxidation derivatives on cholesterol esterifying and cholesteryl ester hydrolytic enzyme activity of cultured rabbit aortic smooth muscle cells. | 1989 | Lipids | pmid:2761354 |
| Xu XX and Lambeth JD | Cholesterol sulfate is a naturally occurring inhibitor of steroidogenesis in isolated rat adrenal mitochondria. | 1989 | J. Biol. Chem. | pmid:2708364 |
| Byers DM et al. | Defective activity of acyl-CoA:cholesterol O-acyltransferase in Niemann-Pick type C and type D fibroblasts. | 1989 | Biochem. J. | pmid:2590161 |
| Larsson O et al. | Abolition of mevinolin-induced growth inhibition in human fibroblasts following transformation by simian virus 40. | 1989 | Cancer Res. | pmid:2551491 |
| Rosser DS et al. | Coordinate regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and prenyltransferase synthesis but not degradation in HepG2 cells. | 1989 | J. Biol. Chem. | pmid:2568358 |
| Molowa DT and Cimis GM | Co-ordinate regulation of low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase and synthase gene expression in HepG2 cells. | 1989 | Biochem. J. | pmid:2569863 |
| Kocsis JF and Carsia RV | Steroidogenic properties of isolated turkey adrenocortical cells. | 1989 | Domest. Anim. Endocrinol. | pmid:2543538 |
| Smith CJ et al. | The response of large and small luteal cells from the pregnant rat to substrates and secretagogues. | 1989 | Biol. Reprod. | pmid:2560405 |
| Saragüeta P et al. | Insulin regulation of steroidogenic activity in rat culture luteal cells. | 1989 | J. Steroid Biochem. | pmid:2468046 |
| Wade DP et al. | Regulation of low-density-lipoprotein-receptor mRNA by insulin in human hepatoma Hep G2 cells. | 1989 | Eur. J. Biochem. | pmid:2471639 |
| Taylor FR and Kandutsch AA | Metabolism of 25-hydroxycholesterol in mammalian cell cultures. Side-chain scission to pregnenolone in mouse L929 fibroblasts. | 1989 | J. Lipid Res. | pmid:2794780 |
| Liscum L and Faust JR | The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one. | 1989 | J. Biol. Chem. | pmid:2745416 |
| Takagi K et al. | Control of low density lipoprotein receptor gene promoter activity. Ketoconazole inhibits serum lipoprotein but not oxysterol suppression of gene transcription. | 1989 | J. Biol. Chem. | pmid:2745447 |
| Miyauchi F et al. | [Regulation of progesterone accumulation in dissociated luteal cells on day 15 of pregnancy in rats]. | 1989 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:2746064 |
| Trzaskos JM et al. | Sterol-mediated suppression of HMG-CoA reductase mRNA levels in cultured cells requires protein synthesis. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2730657 |
| Dawson PA et al. | Purification of oxysterol binding protein from hamster liver cytosol. | 1989 | J. Biol. Chem. | pmid:2722817 |
| von Gunten CF and Sinensky M | Treatment of CHO-K1 cells with 25-hydroxycholesterol produces a more rapid loss of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity than can be accounted for by enzyme turnover. | 1989 | Biochim. Biophys. Acta | pmid:2917146 |
| Petrino TR et al. | Steroidogenesis in Fundulus heteroclitus. I. Production of 17 alpha-hydroxy,20 beta-dihydroprogesterone, testosterone, and 17 beta-estradiol by prematurational follicles in vitro. | 1989 | Gen. Comp. Endocrinol. | pmid:2920896 |
| Lynn WS et al. | Intracellular Ca2+ and cytotoxicity. | 1989 Sep-Oct | Arch. Environ. Health | pmid:2573316 |
| Leonard S et al. | Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21. | 1990 | J. Biol. Chem. | pmid:2180959 |
| Seillan C | Oxysterol mediated changes in fatty acid distribution and lipid synthesis in cultured bovine aortic smooth muscle cells. | 1990 | Lipids | pmid:2110280 |
| Weber H et al. | Dietary protein restriction stress and adrenocortical function: evidence for transient and long-term induction of enhanced cellular function. | 1990 | Endocrinology | pmid:2174347 |
| Roby KF and Terranova PF | Effects of tumor necrosis factor-alpha in vitro on steroidogenesis of healthy and atretic follicles of the rat: theca as a target. | 1990 | Endocrinology | pmid:2109690 |
| Boyce S et al. | Reconstructed skin from cultured human keratinocytes and fibroblasts on a collagen-glycosaminoglycan biopolymer substrate. | 1990 | Skin Pharmacol. | pmid:2127678 |
| Gibson-Berry KL and Chase DJ | Continuous and pulsatile infusions of luteinizing hormone have identical effects on steroidogenic capacity and sensitivity of Leydig cells in rats passively immunized against gonadotropin-releasing hormone. | 1990 | Endocrinology | pmid:1693567 |
| Ludes B et al. | Increased immunogenicity of human renal carcinoma cells following treatment with cholesterol derivatives. | 1990 | Eur. Urol. | pmid:2311641 |
| Rodriguez-Lafrasse C et al. | Abnormal cholesterol metabolism in imipramine-treated fibroblast cultures. Similarities with Niemann-Pick type C disease. | 1990 | Biochim. Biophys. Acta | pmid:2317521 |
| Patel NT and Thompson EB | Human oxysterol-binding protein. I. Identification and characterization in liver. | 1990 | J. Clin. Endocrinol. Metab. | pmid:2229319 |
| Panini SR et al. | Defective elongation of fatty acids in a recessive 25-hydroxycholesterol-resistant mutant cell line. | 1990 | J. Biol. Chem. | pmid:2117604 |
| Mazzone T et al. | Relation of growth- and sterol-related regulatory pathways for low density lipoprotein receptor gene expression. | 1990 | J. Biol. Chem. | pmid:2180958 |
| Guyton JR et al. | Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region. | 1990 | Am. J. Pathol. | pmid:2201200 |
| Gu Y et al. | Inhibitory effect of gossypol on steroidogenic pathways in cultured bovine luteal cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2162666 |
| Saucier SE et al. | Oxygenation of desmosterol and cholesterol in cell cultures. | 1990 | J. Lipid Res. | pmid:2090711 |
| Battista PJ et al. | Differential control of placental lactogen release and progesterone production by ovine placental tissue in vitro. | 1990 Jul-Aug | Placenta | pmid:2235915 |
| Gaffney DK et al. | Cholesterol content but not plasma membrane fluidity influences the susceptibility of L1210 leukemia cells to merocyanine 540-sensitized irradiation. | 1991 | Photochem. Photobiol. | pmid:1798749 |
| Gu Y et al. | Gossypolone suppresses progesterone synthesis in bovine luteal cells. | 1991 | J. Steroid Biochem. Mol. Biol. | pmid:2064986 |
| Hidaka Y et al. | Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. | 1991 | J. Biol. Chem. | pmid:1649182 |
| Bansal N et al. | Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents. | 1991 | FASEB J. | pmid:2004665 |
| Chakrabarti R and Engleman EG | Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation. | 1991 | J. Biol. Chem. | pmid:1712015 |
| Leighton JK et al. | Activation of the silent endogenous cholesterol-7-alpha-hydroxylase gene in rat hepatoma cells: a new complementation group having resistance to 25-hydroxycholesterol. | 1991 | Mol. Cell. Biol. | pmid:2005896 |
| Zhou Q et al. | The effect of 25-hydroxycholesterol on accumulation of intracellular calcium. | 1991 | Cell Calcium | pmid:1834342 |
| Talavera F and Menon KM | Studies on rat luteal cell response to insulin-like growth factor I (IGF-I): identification of a specific cell membrane receptor for IGF-I in the luteinized rat ovary. | 1991 | Endocrinology | pmid:1651848 |
| Dawson PA et al. | Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1991 | J. Biol. Chem. | pmid:1673968 |
| Dharmarajan AM et al. | Estradiol regulation of the rabbit corpus luteum: in vivo and in vitro studies. | 1991 | Endocrinology | pmid:2036954 |
| Wada A et al. | Expression of functional bovine cholesterol side chain cleavage cytochrome P450 (P450scc) in Escherichia coli. | 1991 | Arch. Biochem. Biophys. | pmid:1929405 |
| Constantino CX et al. | Insulin-like growth factor-I stimulates steroidogenesis in rabbit luteal cells. | 1991 | Endocrinology | pmid:2004596 |
| Ng LL and Davies JE | HMG CoA reductase inhibitors affect Na(+)-H+ antiport activity in human lymphoblasts. | 1991 | Am. J. Physiol. | pmid:1659206 |
| Taylor FR et al. | A proteolytic fragment of the oxysterol receptor which retains oxysterol binding activity. | 1991 | Arch. Biochem. Biophys. | pmid:1898049 |
| Zetterberg A and Larsson O | Coordination between cell growth and cell cycle transit in animal cells. | 1991 | Cold Spring Harb. Symp. Quant. Biol. | pmid:1819483 |
| Budd TJ et al. | Characterization of the LDL receptor in rat promegakaryoblasts in culture. | 1991 | Biosci. Rep. | pmid:1863711 |
| de la Llosa-Hermier MP et al. | Evidence for modulation of progesterone secretion by calcium and protein kinase C activators in ovine chorionic cells. | 1991 Sep-Oct | Placenta | pmid:1775444 |
| Roitelman J and Simoni RD | Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. | 1992 | J. Biol. Chem. | pmid:1460026 |
| Taylor FR | Correlation among oxysterol potencies in the regulation of the degradation of 3-hydroxy-3-methylglutaryl CoA reductase, the repression of 3-hydroxy-3-methylglutaryl CoA synthase and affinities for the oxysterol receptor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1352965 |
| Dueland S et al. | Expression of 7 alpha-hydroxylase in non-hepatic cells results in liver phenotypic resistance of the low density lipoprotein receptor to cholesterol repression. | 1992 | J. Biol. Chem. | pmid:1429619 |
| van Heusden GP et al. | Increased cholesterol synthesis in Chinese hamster ovary cells deficient in peroxisomes. | 1992 | Biochim. Biophys. Acta | pmid:1606178 |
| Ridgway ND et al. | Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding. | 1992 | J. Cell Biol. | pmid:1730758 |
| Peffley DM | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control. | 1992 | Somat. Cell Mol. Genet. | pmid:1546367 |
| Izhar M et al. | Bovine placental progesterone synthesis: comparison of first and second trimesters of gestation. | 1992 | Biol. Reprod. | pmid:1591339 |
| Dorset DL | Binary phase behavior of angiotoxic oxidized cholesterols with cholesterol. | 1992 | Biochim. Biophys. Acta | pmid:1511006 |
| Hwang PL | Inhibitors of protein and RNA synthesis block the cytotoxic effects of oxygenated sterols. | 1992 | Biochim. Biophys. Acta | pmid:1379472 |
| Begum-Hasan J and Murphy BE | Influence of 19-nortestosterone and androgens on progesterone biosynthetic enzymes in early human placental explants. | 1992 | J. Steroid Biochem. Mol. Biol. | pmid:1525044 |
| Tuckey RC | Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates. | 1992 | J. Steroid Biochem. Mol. Biol. | pmid:1525048 |
| Chun KT and Simoni RD | The role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1992 | J. Biol. Chem. | pmid:1740463 |