| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Makley LN et al. | Pharmacological chaperone for α-crystallin partially restores transparency in cataract models. | 2015 | Science | pmid:26542570 |
| Iaea DB et al. | A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. | 2015 | J. Lipid Res. | pmid:26497473 |
| Kuder CH et al. | 3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines. | 2015 | Lipids | pmid:26494560 |
| van Lier JE et al. | Cholesterol hydroperoxides as substrates for cholesterol-metabolizing cytochrome P450 enzymes and alternative sources of 25-hydroxycholesterol and other oxysterols. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:26230055 |
| Zhao Q et al. | N-Hydroxyphthalimide catalyzed allylic oxidation of steroids with t-butyl hydroperoxide. | 2015 | Steroids | pmid:25527284 |
| Virginio VW et al. | Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. | 2015 | Free Radic. Res. | pmid:25465091 |
| Zhao Q et al. | Investigation on the synthesis of 25-hydroxycholesterol. | 2014 | Steroids | pmid:24582707 |
| Gold ES et al. | 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24994901 |
| Reboldi A et al. | Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. | 2014 | Science | pmid:25104388 |
| Matsuda H et al. | Regulation of rat hepatic α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase, a key enzyme in the tryptophan- NAD pathway, by dietary cholesterol and sterol regulatory element-binding protein-2. | 2014 | Eur J Nutr | pmid:25289390 |
| Lathe R et al. | Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature. | 2014 | BMC Geriatr | pmid:24656052 |
| Zhong W et al. | OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. | 2014 | Exp. Cell Res. | pmid:24424245 |
| Ren S and Ning Y | Sulfation of 25-hydroxycholesterol regulates lipid metabolism, inflammatory responses, and cell proliferation. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24302009 |
| Civra A et al. | Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Sci Rep | pmid:25501851 |
| Jiang W et al. | Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis. | 2014 | PLoS ONE | pmid:25426949 |
| Larkin JC et al. | The influence of ligand-activated LXR on primary human trophoblasts. | 2014 | Placenta | pmid:25255963 |
| Casella C et al. | Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells. | 2014 | Gynecol. Oncol. | pmid:25134999 |
| Ren S et al. | Identification of novel regulatory cholesterol metabolite, 5-cholesten, 3β,25-diol, disulfate. | 2014 | PLoS ONE | pmid:25072708 |
| Sekiya M et al. | Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages. | 2014 | J. Lipid Res. | pmid:24891333 |
| Linsenbardt AJ et al. | Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. | 2014 | Neuropharmacology | pmid:24878244 |
| Rauer C et al. | Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells. | 2014 | PLoS ONE | pmid:24625548 |
| Fu H et al. | Interleukin-1 potently contributes to 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions. | 2014 | Atherosclerosis | pmid:25463072 |
| Simon A | Cholesterol metabolism and immunity. | 2014 | N. Engl. J. Med. | pmid:25390746 |
| Cyster JG et al. | 25-Hydroxycholesterols in innate and adaptive immunity. | 2014 | Nat. Rev. Immunol. | pmid:25324126 |
| Adiguzel Z et al. | Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols. | 2014 | Mol. Biol. Rep. | pmid:25266234 |
| Stottrup BL et al. | Comparison of cholesterol and 25-hydroxycholesterol in phase-separated langmuir monolayers at the air-water interface. | 2014 | J Phys Chem B | pmid:25188894 |
| Ibrahim SR et al. | Didemnacerides A and B: two new glycerides from Red Sea ascidian Didemnum species. | 2014 | Nat. Prod. Res. | pmid:24938879 |
| Kang PJ et al. | Reprogramming of mouse somatic cells into pluripotent stem-like cells using a combination of small molecules. | 2014 | Biomaterials | pmid:24881998 |
| Engel T et al. | 3β,5α,6β-Cholestanetriol and 25-hydroxycholesterol accumulate in ATP-binding cassette transporter G1 (ABCG1)-deficiency. | 2014 | Atherosclerosis | pmid:24833118 |
| Medina-Meza IG et al. | Kinetics of 25-hydroperoxycholesterol formation during photo-oxidation of crystalline cholesterol. | 2014 | J. Sci. Food Agric. | pmid:24166010 |
| Ikegami T et al. | Increased serum oxysterol concentrations in patients with chronic hepatitis C virus infection. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24525121 |
| Bielska AA et al. | Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling. | 2014 | Biochemistry | pmid:24758724 |
| Ma KL et al. | Interaction of RAS activation and lipid disorders accelerates the progression of glomerulosclerosis. | 2013 | Int J Med Sci | pmid:24151433 |
| Diczfalusy U | On the formation and possible biological role of 25-hydroxycholesterol. | 2013 | Biochimie | pmid:22732193 |
| Ichikawa T et al. | 25-hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway. | 2013 | Exp. Cell Res. | pmid:23485764 |
| Stulov SV et al. | Pregna-5,17(20)-dien-21-oyl amides affecting sterol and triglyceride biosynthesis in Hep G2 cells. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23466231 |
| Shackleford G et al. | Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes. | 2013 | Biochem. Pharmacol. | pmid:23500534 |
| Tuong ZK et al. | Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice. | 2013 | Endocrinology | pmid:23239817 |
| Liu SY et al. | Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. | 2013 | Immunity | pmid:23273844 |
| Tanaka AR et al. | p38MAPK and Rho-dependent kinase are involved in anoikis induced by anicequol or 25-hydroxycholesterol in DLD-1 colon cancer cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23266613 |
| Wu CA et al. | An evaluation of the mechanism of ABCA7 on cellular lipid release in ABCA7-HEC293 cell. | 2013 | Chin. Med. J. | pmid:23324282 |
| Eibinger G et al. | On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment. | 2013 | Exp. Cell Res. | pmid:23541792 |
| Chalubinski M et al. | The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers. | 2013 | Inflamm. Res. | pmid:24077843 |
| Elsabrouty R et al. | Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells. | 2013 | Mol. Biol. Cell | pmid:24025715 |
| Otevrel J et al. | Antimycobacterial and photosynthetic electron transport inhibiting activity of ring-substituted 4-arylamino-7-chloroquinolinium chlorides. | 2013 | Molecules | pmid:24002140 |
| Schmidt AW et al. | Inhibitory effect of oxygenated cholestan-3β-ol derivatives on the growth of Mycobacterium tuberculosis. | 2013 | Bioorg. Med. Chem. Lett. | pmid:24084159 |
| Blanc M et al. | The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. | 2013 | Immunity | pmid:23273843 |
| Dasari B et al. | Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. | 2013 | Curr. Eye Res. | pmid:23841471 |
| Ni J et al. | Activation of renin-angiotensin system is involved in dyslipidemia-mediated renal injuries in apolipoprotein E knockout mice and HK-2 cells. | 2013 | Lipids Health Dis | pmid:23570453 |
| Waltl S et al. | 25-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line. | 2013 | Neurosci. Lett. | pmid:23347841 |