MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hanley K et al. | Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. | 2000 | J. Invest. Dermatol. | pmid:10692116 |
Mailhot G et al. | Influence of the in vivo calcium status on cellular calcium homeostasis and the level of the calcium-binding protein calreticulin in rat hepatocytes. | 2000 | Endocrinology | pmid:10698163 |
Nes WD et al. | Identification of the lipophilic factor produced by macrophages that stimulates steroidogenesis. | 2000 | Endocrinology | pmid:10698170 |
Rusiñol AE et al. | Isolation of a somatic cell mutant resistant to the induction of apoptosis by oxidized low density lipoprotein. | 2000 | J. Biol. Chem. | pmid:10702300 |
Choi JW and Choi HS | The regulatory effects of thyroid hormone on the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 2000 | Endocr. Res. | pmid:10711719 |
Dushkin MI et al. | [Effect of 25-hydroxycholesterol and progesterone on esterification of cholesterol, viscosity, and protein-lipid interactions in macrophage membranes]. | 2000 | Biull Eksp Biol Med | pmid:10732231 |
Flach J et al. | The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733934 |
Li-Hawkins J et al. | Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. | 2000 | J. Biol. Chem. | pmid:10748047 |
Ridgway ND | Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin. | 2000 | Biochim. Biophys. Acta | pmid:10760463 |
Duan H et al. | Sterols and inhibitors of sterol transport modulate the degradation and secretion of macrophage ApoE: requirement for the C-terminal domain. | 2000 | Biochim. Biophys. Acta | pmid:10760464 |