| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hidaka Y et al. | Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. | 1991 | J. Biol. Chem. | pmid:1649182 |
| Ren S et al. | Identification of a novel sulfonated oxysterol, 5-cholesten-3beta,25-diol 3-sulfonate, in hepatocyte nuclei and mitochondria. | 2006 | J. Lipid Res. | pmid:16505492 |
| Ning Y et al. | Cholesterol, LDL, and 25-hydroxycholesterol regulate expression of the steroidogenic acute regulatory protein in microvascular endothelial cell line (bEnd.3). | 2006 | Biochem. Biophys. Res. Commun. | pmid:16516145 |
| Talavera F and Menon KM | Studies on rat luteal cell response to insulin-like growth factor I (IGF-I): identification of a specific cell membrane receptor for IGF-I in the luteinized rat ovary. | 1991 | Endocrinology | pmid:1651848 |
| Westover EJ and Covey DF | Synthesis of ent-25-hydroxycholesterol. | 2006 | Steroids | pmid:16519912 |
| Rodriguez-Agudo D et al. | Localization of StarD5 cholesterol binding protein. | 2006 | J. Lipid Res. | pmid:16534142 |
| Ng LL and Davies JE | HMG CoA reductase inhibitors affect Na(+)-H+ antiport activity in human lymphoblasts. | 1991 | Am. J. Physiol. | pmid:1659206 |
| Prunet C et al. | Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients. | 2006 | Cytometry A | pmid:16604541 |
| Tam SP et al. | ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16611739 |
| Kazeto Y et al. | Cloning and characterization of a cDNA encoding cholesterol side-chain cleavage cytochrome P450 (CYP11A1): tissue-distribution and changes in the transcript abundance in ovarian tissue of Japanese eel, Anguilla japonica, during artificially induced sexual development. | 2006 | J. Steroid Biochem. Mol. Biol. | pmid:16616842 |
| Ferderbar S et al. | Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. | 2007 | Diabetes Metab. Res. Rev. | pmid:16634125 |
| An S et al. | A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2. | 2006 | FEBS Lett. | pmid:16647063 |
| Velázquez E et al. | 25-Hydroxycholesterol has a dual effect on the proliferation of cultured rat astrocytes. | 2006 | Neuropharmacology | pmid:16678217 |
| Wang JH and Tuohimaa P | Regulation of cholesterol 25-hydroxylase expression by vitamin D3 metabolites in human prostate stromal cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16696936 |
| Calleros L et al. | RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion. | 2006 | Apoptosis | pmid:16699960 |
| Dawson PA et al. | Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1991 | J. Biol. Chem. | pmid:1673968 |
| Bennati AM et al. | Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis. | 2006 | Biochim. Biophys. Acta | pmid:16784888 |
| Lee HW et al. | Formation of cholesterol oxidation products in marinated foods during heating. | 2006 | J. Agric. Food Chem. | pmid:16787042 |
| Calleros L et al. | Low cell cholesterol levels increase NFkappaB activity through a p38 MAPK-dependent mechanism. | 2006 | Cell. Signal. | pmid:16806824 |
| Tylavsky FA | Seasonal variation in calcitropic hormones and bone accrual in puberty. | 2006 | Br. J. Nutr. | pmid:16869984 |
| Rakić B et al. | Bleomycin is a potent small-molecule inhibitor of hepatitis C virus replication. | 2006 | Chembiochem | pmid:16888741 |
| Larsson DA et al. | Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. | 2006 | Free Radic. Biol. Med. | pmid:16934673 |
| Gibson-Berry KL and Chase DJ | Continuous and pulsatile infusions of luteinizing hormone have identical effects on steroidogenic capacity and sensitivity of Leydig cells in rats passively immunized against gonadotropin-releasing hormone. | 1990 | Endocrinology | pmid:1693567 |
| Mazalli MR et al. | HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs. | 2006 | Lipids | pmid:16981439 |
| Dushkin MI et al. | Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages. | 2006 | Bull. Exp. Biol. Med. | pmid:16984105 |
| Alrefai WA et al. | Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: Role of sterol regulatory element binding protein 2. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17008555 |
| Chang LL et al. | Effects of crude adlay hull acetone extract on corticosterone release from rat zona fasciculata-reticularis cells. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17019563 |
| Travert C et al. | Induction of apoptosis by 25-hydroxycholesterol in adult rat Leydig cells: protective effect of 17beta-estradiol. | 2006 | Reprod. Toxicol. | pmid:17023141 |
| Lizardo-Daudt HM et al. | Biosynthetic capacity of rainbow trout (Oncorhynchus mykiss) interrenal tissue after cadmium exposure. | 2007 | Arch. Environ. Contam. Toxicol. | pmid:17031756 |
| Pagler TA et al. | A Chinese hamster ovarian cell line imports cholesterol by high density lipoprotein degradation. | 2006 | J. Biol. Chem. | pmid:17038318 |
| Kosztáczky B et al. | Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. | 2006 | Neuropeptides | pmid:17049599 |
| Fernø J et al. | Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. | 2006 | BMC Neurosci | pmid:17052361 |
| Tachibana Y | [Synthesis and structure-activity relationships of bioactive compounds using sterols]. | 2006 | Yakugaku Zasshi | pmid:17077615 |
| Storbeck KH et al. | Evidence for the functional role of residues in the B'-C loop of baboon cytochrome P450 side-chain cleavage (CYP11A1) obtained by site-directed mutagenesis, kinetic analysis and homology modelling. | 2007 | J. Steroid Biochem. Mol. Biol. | pmid:17081746 |
| Bai B et al. | Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line (Caco-2). | 2005 | Inflammation | pmid:17086498 |
| Chakrabarti R and Engleman EG | Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation. | 1991 | J. Biol. Chem. | pmid:1712015 |
| Hsu MH et al. | Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin. | 2007 | J. Biol. Chem. | pmid:17142457 |
| Molina S et al. | The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus. | 2007 | J. Hepatol. | pmid:17156886 |
| Kang MA et al. | Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. | 2007 | Life Sci. | pmid:17161435 |
| Chen W et al. | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. | 2007 | Cell Metab. | pmid:17189208 |
| Han JH et al. | Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition. | 2007 | Brain Res. | pmid:17224136 |
| Vejux A et al. | Cytotoxic oxysterols induce caspase-independent myelin figure formation and caspase-dependent polar lipid accumulation. | 2007 | Histochem. Cell Biol. | pmid:17226048 |
| Ridgway ND et al. | Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding. | 1992 | J. Cell Biol. | pmid:1730758 |
| Wyles JP et al. | Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization. | 2007 | Exp. Cell Res. | pmid:17350617 |
| Erridge C et al. | 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages. | 2007 | Free Radic. Res. | pmid:17364953 |
| Chun KT and Simoni RD | The role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1992 | J. Biol. Chem. | pmid:1740463 |
| Wong J et al. | Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. | 2007 | Lipids Health Dis | pmid:17408498 |
| Suchanek M et al. | The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. | 2007 | Biochem. J. | pmid:17428193 |
| Radhakrishnan A et al. | Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17428920 |
| Schekman R | How sterols regulate protein sorting and traffic. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17428924 |
| Kallin A et al. | SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma. | 2007 | J. Lipid Res. | pmid:17452746 |
| Joffre C et al. | Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. | 2007 | Curr. Eye Res. | pmid:17453947 |
| Saldanha T and Bragagnolo N | Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi). | 2007 | Lipids | pmid:17492472 |
| Tamehiro N et al. | Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. | 2007 | J. Biol. Chem. | pmid:17526932 |
| Wang L et al. | Ribonucleic acid binding protein-mediated regulation of luteinizing hormone receptor expression in granulosa cells: relationship to sterol metabolism. | 2007 | Mol. Endocrinol. | pmid:17550979 |
| Kosztáczky B et al. | Leptin stimulates endogenous cholesterol synthesis in human monocytes: New role of an old player in atherosclerotic plaque formation. Leptin-induced increase in cholesterol synthesis. | 2007 | Int. J. Biochem. Cell Biol. | pmid:17560160 |
| Lee PC et al. | Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells. | 2007 | J. Lipid Res. | pmid:17586788 |
| Ren S et al. | Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17624300 |
| Risé P et al. | Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. | 2007 | Eur. J. Pharmacol. | pmid:17655842 |
| de la Llosa-Hermier MP et al. | Evidence for modulation of progesterone secretion by calcium and protein kinase C activators in ovine chorionic cells. | 1991 Sep-Oct | Placenta | pmid:1775444 |
| Umetani M et al. | 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. | 2007 | Nat. Med. | pmid:17873880 |
| Li X et al. | Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. | 2007 | J. Lipid Res. | pmid:17890683 |
| Gaffney DK et al. | Cholesterol content but not plasma membrane fluidity influences the susceptibility of L1210 leukemia cells to merocyanine 540-sensitized irradiation. | 1991 | Photochem. Photobiol. | pmid:1798749 |
| Infante RE et al. | Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. | 2008 | J. Biol. Chem. | pmid:17989073 |
| Yan D et al. | OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. | 2008 | J. Biol. Chem. | pmid:17991739 |
| Lange Y et al. | Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. | 2008 | J. Biol. Chem. | pmid:18024962 |
| Lizardo-Daudt HM et al. | Cadmium chloride-induced disruption of testicular steroidogenesis in rainbow trout, Oncorhynchus mykiss. | 2008 | Arch. Environ. Contam. Toxicol. | pmid:18040592 |
| Wang PY et al. | The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBP. | 2008 | J. Biol. Chem. | pmid:18165705 |
| Zetterberg A and Larsson O | Coordination between cell growth and cell cycle transit in animal cells. | 1991 | Cold Spring Harb. Symp. Quant. Biol. | pmid:1819483 |
| Gévry N et al. | Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues. | 2008 | J. Lipid Res. | pmid:18272928 |
| Lemaire-Ewing S et al. | 7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent. | 2009 | Cell Biol. Toxicol. | pmid:18317936 |
| Montecucco F et al. | The immune response is involved in atherosclerotic plaque calcification: could the RANKL/RANK/OPG system be a marker of plaque instability? | 2007 | Clin. Dev. Immunol. | pmid:18320012 |
| Zhou Q et al. | The effect of 25-hydroxycholesterol on accumulation of intracellular calcium. | 1991 | Cell Calcium | pmid:1834342 |
| Zerbinatti CV et al. | Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein. | 2008 | Mol Neurodegener | pmid:18348724 |
| Reschly EJ et al. | Ligand specificity and evolution of liver X receptors. | 2008 | J. Steroid Biochem. Mol. Biol. | pmid:18395439 |
| Bowden K and Ridgway ND | OSBP negatively regulates ABCA1 protein stability. | 2008 | J. Biol. Chem. | pmid:18450749 |
| DeBarber AE et al. | Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol. | 2008 | Anal. Biochem. | pmid:18555788 |
| Choi YK et al. | 25-hydroxycholesterol induces mitochondria-dependent apoptosis via activation of glycogen synthase kinase-3beta in PC12 cells. | 2008 | Free Radic. Res. | pmid:18569012 |
| Budd TJ et al. | Characterization of the LDL receptor in rat promegakaryoblasts in culture. | 1991 | Biosci. Rep. | pmid:1863711 |
| Qureischie H et al. | CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk. | 2008 | Brain Res. | pmid:18680734 |
| Porstmann T et al. | SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. | 2008 | Cell Metab. | pmid:18762023 |
| Malvitte L et al. | Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol. | 2008 | Curr. Eye Res. | pmid:18798080 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Kristiana I et al. | Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: implications for cholesterol trafficking to the endoplasmic reticulum. | 2008 Nov-Dec | Biochim. Biophys. Acta | pmid:18838129 |
| Ma Y et al. | 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway. | 2008 | Am. J. Physiol. Endocrinol. Metab. | pmid:18854425 |
| Yanagita T et al. | Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells. | 2008 | Lipids Health Dis | pmid:18925970 |
| Taylor FR et al. | A proteolytic fragment of the oxysterol receptor which retains oxysterol binding activity. | 1991 | Arch. Biochem. Biophys. | pmid:1898049 |
| Ogawa S et al. | A facile synthesis of C-24 and C-25 oxysterols by in situ generated ethyl(trifluoromethyl)dioxirane. | 2009 | Steroids | pmid:18996406 |
| Gale SE et al. | Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. | 2009 | J. Biol. Chem. | pmid:18996837 |
| Noguchi N | Role of oxidative stress in adaptive responses in special reference to atherogenesis. | 2008 | J Clin Biochem Nutr | pmid:19015746 |
| Liu R et al. | Characterization of fluorescent sterol binding to purified human NPC1. | 2009 | J. Biol. Chem. | pmid:19029290 |
| Farquhar MJ and McKeating JA | Primary hepatocytes as targets for hepatitis C virus replication. | 2008 | J. Viral Hepat. | pmid:19087224 |
| Katz R et al. | Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA). | 2009 | Diabetes | pmid:19136658 |
| Pezacki JP et al. | Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. | 2009 | BMC Chem Biol | pmid:19149867 |
| Leblond F et al. | Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19179626 |
| Slominski AT et al. | Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. | 2009 | PLoS ONE | pmid:19190754 |
| Hynynen R et al. | OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. | 2009 | J. Lipid Res. | pmid:19224871 |
| Lu R et al. | FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. | 2009 | J. Lipid Res. | pmid:19229075 |
| Trousson A et al. | 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR. | 2009 | J. Neurochem. | pmid:19250336 |
| RodrÃguez-Acebes S et al. | Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. | 2009 | Biochem. J. | pmid:19260826 |