| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tabas I et al. | Inhibition of acyl coenzyme A:cholesterol acyl transferase in J774 macrophages enhances down-regulation of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase and prevents low density lipoprotein-induced cholesterol accumulation. | 1986 | J. Biol. Chem. | pmid:3949765 |
| St Clair RW et al. | Metabolism of low density lipoproteins by pigeon skin fibroblasts and aortic smooth muscle cells. Comparison of cells from atherosclerosis-susceptible and atherosclerosis-resistant pigeons. | 1986 Mar-Apr | Arteriosclerosis | pmid:3954671 |
| Georgiou M et al. | Steroid synthesis-dependent, oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures. | 1987 | Endocrinology | pmid:2820696 |
| Golos TG and Strauss JF | Regulation of low density lipoprotein receptor gene expression in cultured human granulosa cells: roles of human chorionic gonadotropin, 8-bromo-3',5'-cyclic adenosine monophosphate, and protein synthesis. | 1987 | Mol. Endocrinol. | pmid:2840565 |
| Jingami H et al. | Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum. | 1987 | J. Cell Biol. | pmid:3584246 |
| Beseme F et al. | Rat liver cytosol oxysterol-binding protein. Characterization and comparison with the HTC cell protein. | 1987 | FEBS Lett. | pmid:3803583 |
| Bagavandoss P and Midgley AR | Lack of difference between retinoic acid and retinol in stimulating progesterone production by luteinizing granulosa cells in vitro. | 1987 | Endocrinology | pmid:3036474 |
| Hasumi K et al. | Overaccumulation of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase in a compactin(ML-236B)-resistant mouse cell line with defects in the regulation of its activity. | 1987 | Eur. J. Biochem. | pmid:3569277 |
| Rajkumar K et al. | In vitro binding and utilization of lipoproteins by luteal cells from ferrets treated with dopaminergic drugs during pseudopregnancy. | 1987 | Gen. Comp. Endocrinol. | pmid:3666406 |
| Themmen AP et al. | Comparison of the cellular composition and steroidogenic properties of preparations of interstitial cells isolated from immature and mature rat testis. | 1987 | J. Endocrinol. | pmid:3559448 |
| Larsson O and Johansson BM | Mevalonic acid products as mediators of cell proliferation in simian virus 40-transformed 3T3 cells. | 1987 | Cancer Res. | pmid:3040232 |
| Tomita K et al. | Chinese hamster ovary cell mutant with defective down-regulation of low density lipoprotein receptors. | 1987 | J. Biol. Chem. | pmid:3805025 |
| Liscum L and Faust JR | Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts. | 1987 | J. Biol. Chem. | pmid:3680287 |
| Wong GA et al. | Acetoacetyl-CoA ligase activity in the isolated rat hepatocyte: effects of 25-hydroxycholesterol and high density lipoprotein. | 1987 | Biosci. Rep. | pmid:3663886 |
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| Sampson WJ et al. | The role of acyl-CoA: cholesterol acyltransferase in the metabolism of free cholesterol to cholesteryl esters or bile acids in primary cultures of rat hepatocytes. | 1987 | Biochim. Biophys. Acta | pmid:3593752 |
| Südhof TC et al. | 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. | 1987 | Cell | pmid:3030558 |
| Carsia RV et al. | Ontogenic corticosteroidogenesis of the domestic fowl: response of isolated adrenocortical cells. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3031690 |
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| Bruneau C et al. | Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552054 |
| Lambeth JD et al. | Cholesterol sulfate inhibits adrenal mitochondrial cholesterol side chain cleavage at a site distinct from cytochrome P-450scc. Evidence for an intramitochondrial cholesterol translocator. | 1987 | J. Biol. Chem. | pmid:3597410 |
| Hotta M and Baird A | The inhibition of low density lipoprotein metabolism by transforming growth factor-beta mediates its effects on steroidogenesis in bovine adrenocortical cells in vitro. | 1987 | Endocrinology | pmid:3036466 |
| Huijmans JG et al. | Effect of 25-hydroxy-cholesterol on the uptake of corticosterone in isolated rat liver cells. | 1988 | Horm. Metab. Res. | pmid:3371854 |
| Peffley D et al. | Further characterization of a somatic cell mutant defective in regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1988 | Somat. Cell Mol. Genet. | pmid:2904178 |
| Epand RF and Epand RM | 25-Hydroxycholesterol promotes myelin basic protein-induced leakage of phospholipid vesicles. | 1988 | Biochim. Biophys. Acta | pmid:2449243 |
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| Carsia RV et al. | Protein malnutrition in the domestic fowl induces alterations in adrenocortical function. | 1988 | Endocrinology | pmid:2828009 |
| Lahoua Z et al. | Serum-induced arachidonic acid release and prostaglandin biosynthesis are potentiated by oxygenated sterols in NRK 49F cells. | 1988 | Biochim. Biophys. Acta | pmid:3124881 |
| de la Llosa-Hermier MP et al. | Lack of short-term modulation of in vitro placental progesterone secretion in sheep. | 1988 Nov-Dec | Placenta | pmid:3070536 |
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| Hayashi K et al. | Chicken oocytes and fibroblasts express different apolipoproteins-B-specific receptors. | 1989 | J. Biol. Chem. | pmid:2914946 |
| Metherall JE et al. | Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells. | 1989 | J. Biol. Chem. | pmid:2570073 |
| Morin RJ and Peng SK | Effects of cholesterol oxidation derivatives on cholesterol esterifying and cholesteryl ester hydrolytic enzyme activity of cultured rabbit aortic smooth muscle cells. | 1989 | Lipids | pmid:2761354 |
| Xu XX and Lambeth JD | Cholesterol sulfate is a naturally occurring inhibitor of steroidogenesis in isolated rat adrenal mitochondria. | 1989 | J. Biol. Chem. | pmid:2708364 |
| Byers DM et al. | Defective activity of acyl-CoA:cholesterol O-acyltransferase in Niemann-Pick type C and type D fibroblasts. | 1989 | Biochem. J. | pmid:2590161 |
| Larsson O et al. | Abolition of mevinolin-induced growth inhibition in human fibroblasts following transformation by simian virus 40. | 1989 | Cancer Res. | pmid:2551491 |
| Rosser DS et al. | Coordinate regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and prenyltransferase synthesis but not degradation in HepG2 cells. | 1989 | J. Biol. Chem. | pmid:2568358 |
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| Kocsis JF and Carsia RV | Steroidogenic properties of isolated turkey adrenocortical cells. | 1989 | Domest. Anim. Endocrinol. | pmid:2543538 |
| Smith CJ et al. | The response of large and small luteal cells from the pregnant rat to substrates and secretagogues. | 1989 | Biol. Reprod. | pmid:2560405 |
| Saragüeta P et al. | Insulin regulation of steroidogenic activity in rat culture luteal cells. | 1989 | J. Steroid Biochem. | pmid:2468046 |
| Wade DP et al. | Regulation of low-density-lipoprotein-receptor mRNA by insulin in human hepatoma Hep G2 cells. | 1989 | Eur. J. Biochem. | pmid:2471639 |
| Dawson PA et al. | Purification of oxysterol binding protein from hamster liver cytosol. | 1989 | J. Biol. Chem. | pmid:2722817 |
| von Gunten CF and Sinensky M | Treatment of CHO-K1 cells with 25-hydroxycholesterol produces a more rapid loss of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity than can be accounted for by enzyme turnover. | 1989 | Biochim. Biophys. Acta | pmid:2917146 |
| Petrino TR et al. | Steroidogenesis in Fundulus heteroclitus. I. Production of 17 alpha-hydroxy,20 beta-dihydroprogesterone, testosterone, and 17 beta-estradiol by prematurational follicles in vitro. | 1989 | Gen. Comp. Endocrinol. | pmid:2920896 |