| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ohgane K et al. | Discovery of oxysterol-derived pharmacological chaperones for NPC1: implication for the existence of second sterol-binding site. | 2013 | Chem. Biol. | pmid:23521797 |
| Appukuttan A et al. | Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase. | 2013 | Cardiovasc. Res. | pmid:23729662 |
| Shibata N et al. | 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. | 2013 | J. Biol. Chem. | pmid:24189069 |
| Zhang J et al. | Effect of triptolide on progesterone production from cultured rat granulosa cells. | 2012 | Arzneimittelforschung | pmid:22592319 |
| Wang F et al. | Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis. | 2012 | Cardiovasc. Res. | pmid:21979142 |
| Sugiura H et al. | Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease. | 2012 | Respirology | pmid:22295989 |
| Rosca AM et al. | Cardiomyocyte apoptosis in ischaemia-reperfusion due to the exogenous oxidants at the time of reperfusion. | 2012 | Cell Biol. Int. | pmid:22994946 |
| Koo MS et al. | Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages. | 2012 | Cell Commun. Signal | pmid:22280836 |
| Aye IL et al. | Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF-κB. | 2012 | Mol. Hum. Reprod. | pmid:22238372 |
| Gold ES et al. | ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation. | 2012 | J. Exp. Med. | pmid:22473958 |
| Nishigori M et al. | Highly potent binding and inverse agonist activity of bisphenol A derivatives for retinoid-related orphan nuclear receptor RORγ. | 2012 | Toxicol. Lett. | pmid:22659100 |
| Kostopoulou F et al. | Central role of SREBP-2 in the pathogenesis of osteoarthritis. | 2012 | PLoS ONE | pmid:22662110 |
| Koarai A et al. | 25-Hydroxycholesterol enhances cytokine release and Toll-like receptor 3 response in airway epithelial cells. | 2012 | Respir. Res. | pmid:22849850 |
| Kivelä AM et al. | Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A. | 2012 | Atherosclerosis | pmid:23102786 |
| Lange Y et al. | Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. | 2012 | PLoS ONE | pmid:22276143 |
| Bai Q et al. | VEGF is involved in the increase of dermal microvascular permeability induced by tryptase. | 2012 | ISRN Dermatol | pmid:22666607 |
| Schumacher M et al. | Progesterone synthesis in the nervous system: implications for myelination and myelin repair. | 2012 | Front Neurosci | pmid:22347156 |
| Corman A et al. | Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway. | 2012 | ACS Med Chem Lett | pmid:24900386 |
| Xu L et al. | 25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22275753 |
| Pardali E and Ten Dijke P | TGFβ signaling and cardiovascular diseases. | 2012 | Int. J. Biol. Sci. | pmid:22253564 |
| Lai YL et al. | Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases. | 2012 | J Clin Biochem Nutr | pmid:22247606 |
| Bai Q et al. | Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease. | 2012 | Metab. Clin. Exp. | pmid:22225954 |
| Goto A et al. | Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis. | 2012 | Mol. Biol. Cell | pmid:22875984 |
| Appelqvist H et al. | Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content. | 2012 | PLoS ONE | pmid:23166840 |
| Latif R et al. | Steroidogenesis in amlodipine treated purified Leydig cells. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22032983 |
| Yashiro T et al. | Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins. | 2012 | Atherosclerosis | pmid:22153697 |
| Parisio G et al. | Flip-flop of steroids in phospholipid bilayers: effects of the chemical structure on transbilayer diffusion. | 2012 | J. Am. Chem. Soc. | pmid:22738146 |
| Baker ME et al. | 3D models of human ERα and ERβ complexed with 5-androsten-3β,17β-diol. | 2012 | Steroids | pmid:22921477 |
| RodrÃguez-Carpena JG et al. | Inhibition of cholesterol oxidation products (COPs) formation in emulsified porcine patties by phenolic-rich avocado (Persea americana Mill.) extracts. | 2012 | J. Agric. Food Chem. | pmid:22292505 |
| Roberg-Larsen H et al. | High sensitivity measurements of active oxysterols with automated filtration/filter backflush-solid phase extraction-liquid chromatography-mass spectrometry. | 2012 | J Chromatogr A | pmid:22410154 |
| Guo J et al. | HCV NS5A and NS5B enhance expression of human ceramide glucosyltransferase gene. | 2012 | Virol Sin | pmid:22270805 |
| Siam A et al. | Comparative modeling of 25-hydroxycholesterol-7α-hydroxylase (CYP7B1): ligand binding and analysis of hereditary spastic paraplegia type 5 CYP7B1 mutations. | 2012 | J Mol Model | pmid:21541746 |
| Catarino S et al. | Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells. | 2012 | Acta Ophthalmol | pmid:22313893 |
| Yu PL et al. | Antisteroidogenic effects of hydrogen peroxide on rat granulosa cells. | 2012 | Free Radic. Res. | pmid:22397630 |
| Bielska AA et al. | Synthesis of the enantiomer of the oxysterol-antagonist LY295427. | 2011 Sep-Oct | Steroids | pmid:21470559 |
| Medina MW et al. | Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. | 2011 | PLoS ONE | pmid:21559365 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Ebrahimi KB and Handa JT | Lipids, lipoproteins, and age-related macular degeneration. | 2011 | J Lipids | pmid:21822496 |
| Thorsell AG et al. | Comparative structural analysis of lipid binding START domains. | 2011 | PLoS ONE | pmid:21738568 |
| Rehman S et al. | Antiviral drugs against hepatitis C virus. | 2011 | Genet Vaccines Ther | pmid:21699699 |
| Zhou T et al. | OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62. | 2011 | PLoS ONE | pmid:21698267 |
| Honda A et al. | Cholesterol 25-hydroxylation activity of CYP3A. | 2011 | J. Lipid Res. | pmid:21576599 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| Shan PF et al. | Apelin attenuates the osteoblastic differentiation of vascular smooth muscle cells. | 2011 | PLoS ONE | pmid:21437254 |
| Cho SY et al. | Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. | 2011 | FEBS Lett. | pmid:21944868 |
| Jo Y et al. | Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2011 | J. Biol. Chem. | pmid:21343306 |
| Davis W | The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells. | 2011 | Biochim. Biophys. Acta | pmid:21810484 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Dasari B et al. | Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. | 2011 | BMC Ophthalmol | pmid:21851605 |
| Pachikian BD et al. | Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. | 2011 | PLoS ONE | pmid:21853118 |