| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shen C et al. | Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway. | 2017 | EBioMedicine | pmid:28161398 |
| Kawamura K and Kummerow FA | Effect of 25-hydroxycholesterol on cytotoxicity and prostacyclin production in cultured human umbilical arterial endothelial cells. | 1992 | Eicosanoids | pmid:1419077 |
| Augustowska K et al. | Effects of dioxin (2,3,7,8-TCDD) and PCDDs/PCDFs congeners mixture on steroidogenesis in human placenta tissue culture. | 2003 | Endocr Regul | pmid:12916318 |
| Choi JW and Choi HS | The regulatory effects of thyroid hormone on the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 2000 | Endocr. Res. | pmid:10711719 |
| Georgiou M et al. | Steroid synthesis-dependent, oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures. | 1987 | Endocrinology | pmid:2820696 |
| Veldhuis JD et al. | Synergistic actions of estradiol and the insulin-like growth factor somatomedin-C on swine ovarian (granulosa) cells. | 1986 | Endocrinology | pmid:3732135 |
| Bagavandoss P and Midgley AR | Lack of difference between retinoic acid and retinol in stimulating progesterone production by luteinizing granulosa cells in vitro. | 1987 | Endocrinology | pmid:3036474 |
| Tonkowicz PA and Poisner AM | Evidence for a role for adenosine 3',5'-monophosphate in progesterone secretion by human chorion. | 1985 | Endocrinology | pmid:2578384 |
| Pulley DD and Marrone BL | Inhibitory action of epidermal growth factor on progesterone biosynthesis in hen granulosa cells during short term culture: two sites of action. | 1986 | Endocrinology | pmid:3009155 |
| Quinn PG et al. | Differences in the control of sterol metabolism between mouse and rat Leydig cells. | 1985 | Endocrinology | pmid:3996314 |
| Kliman HJ et al. | Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. | 1986 | Endocrinology | pmid:3512258 |
| Mellon SH and Bair SR | 25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor-1 (SF-1). | 1998 | Endocrinology | pmid:9607816 |
| Lino J et al. | Multihormone regulation of steroidogenesis in cultured porcine granulosa cells: studies in serum-free medium. | 1985 | Endocrinology | pmid:3922742 |
| Tuong ZK et al. | Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice. | 2013 | Endocrinology | pmid:23239817 |
| Georgiou M and Payne AH | 25-Hydroxycholesterol-supported and 8-bromo-adenosine 3',5'-monophosphate-stimulated testosterone production by primary cultures of two populations of rat Leydig cells. | 1985 | Endocrinology | pmid:4017960 |
| Holt JA and Schreiber JR | Estrogen regulation of steroidogenesis in rabbit luteal cells. | 1985 | Endocrinology | pmid:4065041 |
| Jones PB and Hsueh AJ | Pregnenolone biosynthesis by cultured rat granulosa cells: modulation by follicle-stimulating hormone and gonadotropin-releasing hormone. | 1982 | Endocrinology | pmid:6286281 |
| Silavin SL et al. | Reevaluation of the effects of cytochalasins on steroidogenesis: studies on hamster granulosa cells. | 1984 | Endocrinology | pmid:6592092 |
| Mailhot G et al. | Influence of the in vivo calcium status on cellular calcium homeostasis and the level of the calcium-binding protein calreticulin in rat hepatocytes. | 2000 | Endocrinology | pmid:10698163 |
| Nes WD et al. | Identification of the lipophilic factor produced by macrophages that stimulates steroidogenesis. | 2000 | Endocrinology | pmid:10698170 |
| Mason JI and Hemsell PG | Cholesterol sulfate metabolism in human fetal adrenal mitochondria. | 1982 | Endocrinology | pmid:7084110 |
| Doris PA et al. | Ouabain production by cultured adrenal cells. | 1996 | Endocrinology | pmid:8593799 |
| Chen H et al. | Depletion and repopulation of Leydig cells in the testes of aging brown Norway rats. | 1996 | Endocrinology | pmid:8754773 |
| Sekar N and Veldhuis JD | Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways. | 2001 | Endocrinology | pmid:11416012 |
| Weber H et al. | Dietary protein restriction stress and adrenocortical function: evidence for transient and long-term induction of enhanced cellular function. | 1990 | Endocrinology | pmid:2174347 |
| Toaff ME et al. | Metabolism of 25-hydroxycholesterol by rat luteal mitochondria and dispersed cells. | 1982 | Endocrinology | pmid:6291900 |
| Roby KF and Terranova PF | Effects of tumor necrosis factor-alpha in vitro on steroidogenesis of healthy and atretic follicles of the rat: theca as a target. | 1990 | Endocrinology | pmid:2109690 |
| Talavera F and Menon KM | Studies on rat luteal cell response to insulin-like growth factor I (IGF-I): identification of a specific cell membrane receptor for IGF-I in the luteinized rat ovary. | 1991 | Endocrinology | pmid:1651848 |
| Gibson-Berry KL and Chase DJ | Continuous and pulsatile infusions of luteinizing hormone have identical effects on steroidogenic capacity and sensitivity of Leydig cells in rats passively immunized against gonadotropin-releasing hormone. | 1990 | Endocrinology | pmid:1693567 |
| Johnston D et al. | Reduction in cell-associated low density lipoprotein in dexamethasone-treated HeLa cells: suggested mechanism. | 1983 | Endocrinology | pmid:6872959 |
| Dharmarajan AM et al. | Estradiol regulation of the rabbit corpus luteum: in vivo and in vitro studies. | 1991 | Endocrinology | pmid:2036954 |
| Constantino CX et al. | Insulin-like growth factor-I stimulates steroidogenesis in rabbit luteal cells. | 1991 | Endocrinology | pmid:2004596 |
| Carsia RV et al. | Protein malnutrition in the domestic fowl induces alterations in adrenocortical function. | 1988 | Endocrinology | pmid:2828009 |
| Hotta M and Baird A | The inhibition of low density lipoprotein metabolism by transforming growth factor-beta mediates its effects on steroidogenesis in bovine adrenocortical cells in vitro. | 1987 | Endocrinology | pmid:3036466 |
| Villeneuve DL et al. | Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor. | 2009 | Environ. Health Perspect. | pmid:19440503 |
| Matsuda H et al. | Regulation of rat hepatic α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase, a key enzyme in the tryptophan- NAD pathway, by dietary cholesterol and sterol regulatory element-binding protein-2. | 2014 | Eur J Nutr | pmid:25289390 |
| O'Callaghan YC et al. | Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations. | 1999 | Eur J Nutr | pmid:10784381 |
| Dugas B et al. | Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol. | 2010 | Eur J Nutr | pmid:20339855 |
| Alba G et al. | 7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils. | 2016 | Eur J Nutr | pmid:26715521 |
| Zhang J et al. | 7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes. | 1997 | Eur. J. Biochem. | pmid:9249018 |
| Cighetti G et al. | A simple model for studies on the regulation of cholesterol synthesis using freshly isolated hepatocytes. | 1983 | Eur. J. Biochem. | pmid:6861742 |
| Hasumi K et al. | Overaccumulation of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase in a compactin(ML-236B)-resistant mouse cell line with defects in the regulation of its activity. | 1987 | Eur. J. Biochem. | pmid:3569277 |
| Plemenitas A and Watson JA | Down-regulation of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with highly purified liposomal cholesterol. | 1999 | Eur. J. Biochem. | pmid:10561571 |
| Tauber JP et al. | Up-regulation in vascular endothelial cells of binding sites of high density lipoprotein induced by 25-hydroxycholesterol. | 1981 | Eur. J. Biochem. | pmid:6273153 |
| Wade DP et al. | Regulation of low-density-lipoprotein-receptor mRNA by insulin in human hepatoma Hep G2 cells. | 1989 | Eur. J. Biochem. | pmid:2471639 |
| Toll A et al. | 7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase. | 1994 | Eur. J. Biochem. | pmid:7925343 |
| Rosklint T et al. | Oxysterols induce interleukin-1beta production in human macrophages. | 2002 | Eur. J. Clin. Invest. | pmid:11851725 |
| Bertherat J | The nuclear receptor SF-1 (steroidogenic factor-1) is no longer an orphan. | 1998 | Eur. J. Endocrinol. | pmid:9461312 |
| Guo X et al. | Inhibition of hepatocyte gap junctional communication by 25-hydroxycholesterol may be mediated through free radicals. | 1993 | Eur. J. Pharmacol. | pmid:8181541 |
| Risé P et al. | Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. | 2007 | Eur. J. Pharmacol. | pmid:17655842 |
| Ludes B et al. | Increased immunogenicity of human renal carcinoma cells following treatment with cholesterol derivatives. | 1990 | Eur. Urol. | pmid:2311641 |
| Hutson JC | Physiologic interactions between macrophages and Leydig cells. | 2006 | Exp. Biol. Med. (Maywood) | pmid:16380639 |
| Ichikawa T et al. | 25-hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway. | 2013 | Exp. Cell Res. | pmid:23485764 |
| Ayala-Torres S et al. | Apoptosis induced by oxysterol in CEM cells is associated with negative regulation of c-myc. | 1999 | Exp. Cell Res. | pmid:9882528 |
| Eibinger G et al. | On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment. | 2013 | Exp. Cell Res. | pmid:23541792 |
| Zhong W et al. | OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. | 2014 | Exp. Cell Res. | pmid:24424245 |
| Wyles JP et al. | Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization. | 2007 | Exp. Cell Res. | pmid:17350617 |
| Carlberg M and Larsson O | Stimulatory effect of PDGF on HMG-CoA reductase activity and N-linked glycosylation contributes to increased expression of IGF-1 receptors in human fibroblasts. | 1996 | Exp. Cell Res. | pmid:8635486 |
| Palladini G et al. | Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635497 |
| Palladini G et al. | Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635498 |
| Girão H et al. | Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases. | 2003 | Exp. Cell Res. | pmid:14644170 |
| Zhong W et al. | OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. | 2011 | Exp. Cell Res. | pmid:21669198 |
| Ayala-Torres S et al. | Characteristics of 25-hydroxycholesterol-induced apoptosis in the human leukemic cell line CEM. | 1997 | Exp. Cell Res. | pmid:9281350 |
| Rosignoli C et al. | Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo. | 2003 | Exp. Dermatol. | pmid:12930306 |
| Gregorio-King CC et al. | Effect of oxysterols on hematopoietic progenitor cells. | 2002 | Exp. Hematol. | pmid:12135663 |
| Kim JW et al. | Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro. | 2002 | Exp. Mol. Med. | pmid:12085989 |
| Janakidevi K et al. | Mosaicism in female hybrid hares heterozygous for glucose-6-phosphate dehydrogenase. VI. Production of monotypism in the aortas of 4 of 10 mosaic hares fed cholesterol oxidation products. | 1984 | Exp. Mol. Pathol. | pmid:6510509 |
| Bansal N et al. | Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents. | 1991 | FASEB J. | pmid:2004665 |
| Meaney S | Is C-26 hydroxylation an evolutionarily conserved steroid inactivation mechanism? | 2005 | FASEB J. | pmid:16051688 |
| Beseme F et al. | Rat liver cytosol oxysterol-binding protein. Characterization and comparison with the HTC cell protein. | 1987 | FEBS Lett. | pmid:3803583 |
| Harada K et al. | Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway. | 1997 | FEBS Lett. | pmid:9247143 |
| Chiloeches A et al. | Effect of mevalonate availability on the association of G-protein alpha-subunits with the plasma membrane in GH4C1 cells. | 1997 | FEBS Lett. | pmid:9003808 |
| Kisseleva AF et al. | Distribution of exogenous 25-hydroxycholesterol in Hep G2 cells between two different pools. | 1999 | FEBS Lett. | pmid:10100635 |
| Cho SY et al. | Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. | 2011 | FEBS Lett. | pmid:21944868 |
| Monier S et al. | Oligomerization of VIP21-caveolin in vitro is stabilized by long chain fatty acylation or cholesterol. | 1996 | FEBS Lett. | pmid:8690074 |
| Defay R et al. | Physico-chemical properties of the hydroxysterol binding protein of human lymphocyte cytosol. Effects of high salt concentrations and molybdate. | 1984 | FEBS Lett. | pmid:6745440 |
| An S et al. | A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2. | 2006 | FEBS Lett. | pmid:16647063 |
| Nunomura S et al. | Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners. | 2010 | FEBS Lett. | pmid:20138879 |
| Sharma I et al. | Role of 8-iso-prostaglandin F2alpha and 25-hydroxycholesterol in the pathophysiology of endometriosis. | 2010 | Fertil. Steril. | pmid:19324352 |
| Dain L et al. | Regulation of the steroidogenic response of cultured human granulosa cells: effects of serum and 25-hydroxycholesterol. | 1995 | Fertil. Steril. | pmid:7615112 |
| Clariana M and GarcÃa-Regueiro JA | Effect of high pressure processing on cholesterol oxidation products in vacuum packaged sliced dry-cured ham. | 2011 | Food Chem. Toxicol. | pmid:21426921 |
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Larsson DA et al. | Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. | 2006 | Free Radic. Biol. Med. | pmid:16934673 |
| Choi YK et al. | 25-hydroxycholesterol induces mitochondria-dependent apoptosis via activation of glycogen synthase kinase-3beta in PC12 cells. | 2008 | Free Radic. Res. | pmid:18569012 |
| Erridge C et al. | 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages. | 2007 | Free Radic. Res. | pmid:17364953 |
| Virginio VW et al. | Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. | 2015 | Free Radic. Res. | pmid:25465091 |
| Yu PL et al. | Antisteroidogenic effects of hydrogen peroxide on rat granulosa cells. | 2012 | Free Radic. Res. | pmid:22397630 |
| Schumacher M et al. | Progesterone synthesis in the nervous system: implications for myelination and myelin repair. | 2012 | Front Neurosci | pmid:22347156 |
| Jung D et al. | Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. | 2002 | Gastroenterology | pmid:12055601 |
| Leusch FD and MacLatchy DL | In vivo implants of beta-sitosterol cause reductions of reactive cholesterol pools in mitochondria isolated from gonads of male goldfish (Carassius auratus). | 2003 | Gen. Comp. Endocrinol. | pmid:14636632 |
| Rajkumar K et al. | In vitro binding and utilization of lipoproteins by luteal cells from ferrets treated with dopaminergic drugs during pseudopregnancy. | 1987 | Gen. Comp. Endocrinol. | pmid:3666406 |
| Srivastava RK and Van der Kraak G | Insulin as an amplifier of gonadotropin action on steroid production: mechanisms and sites of action in goldfish prematurational full-grown ovarian follicles. | 1994 | Gen. Comp. Endocrinol. | pmid:7926656 |
| Vilchis F et al. | The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus). | 2002 | Gen. Comp. Endocrinol. | pmid:12093115 |
| Singh V et al. | Purification and identification of 25-hydroxycholesterol in a reptile: Seasonal variation and hormonal regulation. | 2017 | Gen. Comp. Endocrinol. | pmid:28126346 |
| Carsia RV and McIlroy PJ | Dietary protein restriction stress in the domestic turkey (Meleagris gallopavo) induces hypofunction and remodeling of adrenal steroidogenic tissue. | 1998 | Gen. Comp. Endocrinol. | pmid:9446731 |
| Petrino TR et al. | Steroidogenesis in Fundulus heteroclitus. I. Production of 17 alpha-hydroxy,20 beta-dihydroprogesterone, testosterone, and 17 beta-estradiol by prematurational follicles in vitro. | 1989 | Gen. Comp. Endocrinol. | pmid:2920896 |
| Nishimura T et al. | Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP. | 2005 | Genes Cells | pmid:16098143 |
| Rehman S et al. | Antiviral drugs against hepatitis C virus. | 2011 | Genet Vaccines Ther | pmid:21699699 |
| Larsson O | Cell cycle-specific growth inhibition of human breast cancer cells induced by metabolic inhibitors. | 1993 | Glycobiology | pmid:8286860 |
| Casella C et al. | Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells. | 2014 | Gynecol. Oncol. | pmid:25134999 |