Berkhout TA et al. |
The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
1996 |
J. Biol. Chem. |
pmid:8662919
|
Aupeix K et al. |
Oyxsterols induce membrane procoagulant activity in monocytic THP-1 cells. |
1996 |
Biochem. J. |
pmid:8615754
|
Spicer LJ et al. |
Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis. |
1996 |
J. Endocrinol. |
pmid:8994382
|
Richardson MA et al. |
Human liposarcoma cell line, SW872, secretes cholesteryl ester transfer protein in response to cholesterol. |
1996 |
J. Lipid Res. |
pmid:8725167
|
Taniguchi S et al. |
Dehydroepiandrosterone markedly inhibits the accumulation of cholesteryl ester in mouse macrophage J774-1 cells. |
1996 |
Atherosclerosis |
pmid:8879442
|
Warren JT and Gilbert LI |
Metabolism in vitro of cholesterol and 25-hydroxycholesterol by the larval prothoracic glands of Manduca sexta. |
1996 Sep-Oct |
Insect Biochem. Mol. Biol. |
pmid:9014337
|
Zhang J et al. |
Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase. |
1997 |
Biochim. Biophys. Acta |
pmid:9059514
|
Ares MP et al. |
Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells. |
1997 |
J. Lipid Res. |
pmid:9374127
|
Phelan KD and Mahler HR |
Acute exposure to 25-hydroxy-cholesterol selectively reduces GABAb and not GABAa receptor-mediated synaptic inhibition. |
1997 |
Biochem. Biophys. Res. Commun. |
pmid:9266831
|
Harada K et al. |
Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway. |
1997 |
FEBS Lett. |
pmid:9247143
|
Zhang J et al. |
7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes. |
1997 |
Eur. J. Biochem. |
pmid:9249018
|
Chiloeches A et al. |
Effect of mevalonate availability on the association of G-protein alpha-subunits with the plasma membrane in GH4C1 cells. |
1997 |
FEBS Lett. |
pmid:9003808
|
Tatidis L et al. |
Decreased feedback regulation of low density lipoprotein receptor activity by sterols in leukemic cells from patients with acute myelogenous leukemia. |
1997 |
J. Lipid Res. |
pmid:9458267
|
Peffley DM and Gayen AK |
Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. |
1997 |
Arch. Biochem. Biophys. |
pmid:9016820
|
Lagace TA et al. |
Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain. |
1997 |
Biochem. J. |
pmid:9337870
|
Baum CL et al. |
Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion. |
1997 |
J. Biol. Chem. |
pmid:9045674
|
Zhang J et al. |
Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. |
1997 |
Biochem. J. |
pmid:9078259
|
Lehmann JM et al. |
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. |
1997 |
J. Biol. Chem. |
pmid:9013544
|
Bhuvaneswaran C et al. |
Activation of acyl-CoA: cholesterol acyltransferase in rat liver microsomes by 25-hydroxycholesterol. |
1997 |
Biochem. Pharmacol. |
pmid:8960060
|
Johnson BH et al. |
Glucocorticoid/oxysterol-induced DNA lysis in human leukemic cells. |
1997 |
J. Steroid Biochem. Mol. Biol. |
pmid:9328208
|
Miura S et al. |
Cholesterol-mediated changes of neutral cholesterol esterase activity in macrophages. Mechanism for mobilization of cholesteryl esters in lipid droplets by HDL. |
1997 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:9409290
|
Musatov MI et al. |
[Effect of oxidized cholesterol derivatives on lymphokine stimulated differentiation of macrophages and primary allogenic mixed human lymphocyte culture]. |
1997 |
Biull Eksp Biol Med |
pmid:9483320
|
Chang JY et al. |
Establishment of two morphologically distinct PC12 cell lines resistant to 25-OH-cholesterol toxicity. |
1997 |
Biochem. Biophys. Res. Commun. |
pmid:9344846
|
Duan H et al. |
Degradation of macrophage ApoE in a nonlysosomal compartment. Regulation by sterols. |
1997 |
J. Biol. Chem. |
pmid:9388269
|
Chang JY and Liu LZ |
25-Hydroxycholesterol causes death but does not prevent nerve growth factor-induced neurite outgrowth in PC12 cells. |
1997 |
Neurochem. Int. |
pmid:9308000
|
Ayala-Torres S et al. |
Characteristics of 25-hydroxycholesterol-induced apoptosis in the human leukemic cell line CEM. |
1997 |
Exp. Cell Res. |
pmid:9281350
|
McCourt MP et al. |
X-ray crystal structure of cytotoxic oxidized cholesterols: 7-ketocholesterol and 25-hydroxycholesterol. |
1997 |
J. Lipid Res. |
pmid:9186918
|
Liu Y et al. |
Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory function for IL-8 production. |
1997 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:9081687
|
Wohlfeil ER and Campbell WB |
25-Hydroxycholesterol enhances eicosanoid production in cultured bovine coronary artery endothelial cells by increasing prostaglandin G/H synthase-2. |
1997 |
Biochim. Biophys. Acta |
pmid:9084508
|
Lala DS et al. |
Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. |
1997 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9144161
|
Babischkin JS et al. |
Estrogen stimulation of P450 cholesterol side-chain cleavage activity in cultures of human placental syncytiotrophoblasts. |
1997 |
Biol. Reprod. |
pmid:9002660
|
Chang JY et al. |
Neurotoxicity of 25-OH-cholesterol on sympathetic neurons. |
1998 |
Brain Res. Bull. |
pmid:9566506
|
Kato H et al. |
Macrophage inhibition of lymphocyte and tumor cell growth is mediated by 25-hydroxycholesterol in the cell membrane. |
1998 |
Int. Arch. Allergy Immunol. |
pmid:9751851
|
Nohturfft A et al. |
Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. |
1998 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9789003
|
Chang JY et al. |
Cholesterol oxides induce programmed cell death in microglial cells. |
1998 |
Biochem. Biophys. Res. Commun. |
pmid:9731219
|
Mellon SH and Bair SR |
25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor-1 (SF-1). |
1998 |
Endocrinology |
pmid:9607816
|
Halvorsen B et al. |
Effect of a coffee lipid (cafestol) on cholesterol metabolism in human skin fibroblasts. |
1998 |
J. Lipid Res. |
pmid:9555953
|
Thewke DP et al. |
Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins. |
1998 |
J. Biol. Chem. |
pmid:9694903
|
Storey MK et al. |
Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol. |
1998 |
Biochem. J. |
pmid:9806908
|
Suresh S et al. |
Cellular cholesterol storage in the Niemann-Pick disease type C mouse is associated with increased expression and defective processing of apolipoprotein D. |
1998 |
J. Neurochem. |
pmid:9422368
|
Fu Q et al. |
Control of cholesterol biosynthesis in Schwann cells. |
1998 |
J. Neurochem. |
pmid:9681444
|
Lin HS et al. |
Synthesis of 4 alpha-(2-propenyl)-5,6-secocholestan-3 alpha-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4 alpha-(2-propenyl)-5 alpha-cholestan-3 alpha-ol. |
1998 |
Steroids |
pmid:9589554
|
Stengel D et al. |
Inhibition of LPL expression in human monocyte-derived macrophages is dependent on LDL oxidation state: a key role for lysophosphatidylcholine. |
1998 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:9672079
|
Dushkin M et al. |
Effects of oxysterols upon macrophage and lymphocyte functions in vitro. |
1998 |
Prostaglandins Other Lipid Mediat. |
pmid:9644113
|
Christenson LK et al. |
Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions. |
1998 |
J. Biol. Chem. |
pmid:9804848
|
Bucci C et al. |
Free fatty acids modulate LDL receptor activity in BHK-21 cells. |
1998 |
Atherosclerosis |
pmid:9622276
|
Chang JY and Liu LZ |
Neurotoxicity of cholesterol oxides on cultured cerebellar granule cells. |
1998 |
Neurochem. Int. |
pmid:9596554
|
Grøndahl C et al. |
Meiosis-activating sterol promotes resumption of meiosis in mouse oocytes cultured in vitro in contrast to related oxysterols. |
1998 |
Biol. Reprod. |
pmid:9603267
|
Kaur M et al. |
Receptor-Ck-dependent regulation of genes involved in the cell cycle. |
1998 |
Mol. Cell. Biochem. |
pmid:9562250
|
Ellsworth JL and Starr JR |
Inhibition of acyl coenzyme A:cholesterol acyltransferase blocks esterification but not uptake of cholesterol in Caco-2 cells. |
1998 |
Metab. Clin. Exp. |
pmid:9500571
|
Rosenfeld JM and Osborne TF |
HLH106, a Drosophila sterol regulatory element-binding protein in a natural cholesterol auxotroph. |
1998 |
J. Biol. Chem. |
pmid:9632664
|
Moog C et al. |
Oxysterols, but not cholesterol, inhibit human immunodeficiency virus replication in vitro. |
1998 |
Antivir. Chem. Chemother. |
pmid:9865387
|
Carsia RV and McIlroy PJ |
Dietary protein restriction stress in the domestic turkey (Meleagris gallopavo) induces hypofunction and remodeling of adrenal steroidogenic tissue. |
1998 |
Gen. Comp. Endocrinol. |
pmid:9446731
|
Chang JY et al. |
Neurotoxicity of 25-OH-cholesterol on NGF-differentiated PC12 cells. |
1998 |
Neurochem. Res. |
pmid:9482261
|
Nilsson J et al. |
Lipoprotein-like phospholipid particles inhibit the smooth muscle cell cytotoxicity of lysophosphatidylcholine and platelet-activating factor. |
1998 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:9445250
|
Ridgway ND et al. |
Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A. |
1998 |
Biochim. Biophys. Acta |
pmid:9487139
|
Norlin M and Wikvall K |
Biochemical characterization of the 7alpha-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes. |
1998 |
Biochim. Biophys. Acta |
pmid:9487148
|
Holleran AL et al. |
Effect of tamoxifen on cholesterol synthesis in HepG2 cells and cultured rat hepatocytes. |
1998 |
Metab. Clin. Exp. |
pmid:9867082
|
Bertherat J |
The nuclear receptor SF-1 (steroidogenic factor-1) is no longer an orphan. |
1998 |
Eur. J. Endocrinol. |
pmid:9461312
|
Brown A et al. |
Manipulation of cholesterol and cholesteryl ester synthesis has multiple effects on the metabolism of apolipoprotein B and the secretion of very-low-density lipoprotein by primary hepatocyte cultures. |
1999 |
Biochim. Biophys. Acta |
pmid:10521709
|
Espenshade PJ et al. |
Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. |
1999 |
J. Biol. Chem. |
pmid:10428864
|
Cheng D et al. |
Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins. |
1999 |
J. Biol. Chem. |
pmid:10428865
|
Rodway MR et al. |
Steroid regulation of progesterone synthesis in a stable porcine granulosa cell line: a role for progestins. |
1999 |
J. Steroid Biochem. Mol. Biol. |
pmid:10416831
|
Plemenitas A and Watson JA |
Down-regulation of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with highly purified liposomal cholesterol. |
1999 |
Eur. J. Biochem. |
pmid:10561571
|
Kisseleva AF et al. |
Distribution of exogenous 25-hydroxycholesterol in Hep G2 cells between two different pools. |
1999 |
FEBS Lett. |
pmid:10100635
|
Dushkin MI et al. |
[Effects of hydroxysterols on expression of inflammatory cytokine genes and their level in macrophages tolerant to endotoxin]. |
1999 |
Biull Eksp Biol Med |
pmid:10190010
|
Parish EJ et al. |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by side-chain oxysterols and their derivatives. |
1999 |
Crit. Rev. Biochem. Mol. Biol. |
pmid:10517646
|
Ravid T et al. |
Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation in lovastatin-resistant cells. |
1999 |
J. Biol. Chem. |
pmid:10506194
|
McCluskey S et al. |
Alpha-tocopherol inhibits oxidative stress induced by cholestanetriol and 25-hydroxycholesterol in porcine ovarian granulosa cells. |
1999 |
Mol. Cell. Biochem. |
pmid:10391143
|
Sparrow SM et al. |
U18666A inhibits intracellular cholesterol transport and neurotransmitter release in human neuroblastoma cells. |
1999 |
Neurochem. Res. |
pmid:9973239
|
Du EZ et al. |
Translocation-arrested apolipoprotein B evades proteasome degradation via a sterol-sensitive block in ubiquitin conjugation. |
1999 |
J. Biol. Chem. |
pmid:9880570
|
Ayala-Torres S et al. |
Apoptosis induced by oxysterol in CEM cells is associated with negative regulation of c-myc. |
1999 |
Exp. Cell Res. |
pmid:9882528
|
Rodway MR et al. |
Regulation of steroidogenesis in jc-410, a stable cell line of porcine granulosa origin. |
1999 |
Mol. Cell. Endocrinol. |
pmid:10221774
|
Jang MK et al. |
Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. |
1999 |
Biochem. Biophys. Res. Commun. |
pmid:10558912
|
O'Callaghan YC et al. |
Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations. |
1999 |
Eur J Nutr |
pmid:10784381
|
Lagace TA et al. |
Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. |
1999 |
J. Lipid Res. |
pmid:9869656
|
Lange Y et al. |
Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol. |
1999 |
J. Lipid Res. |
pmid:10588952
|
Kreklau EL et al. |
Nitric oxide inhibits human aldosteronogenesis without guanylyl cyclase stimulation. |
1999 |
Mol. Cell. Endocrinol. |
pmid:10459858
|
Rao ML et al. |
Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides. |
1999 |
Ann. N. Y. Acad. Sci. |
pmid:10672272
|
Wohlfeil ER and Campbell WB |
25-hydroxycholesterol increases eicosanoids and alters morphology in cultured pulmonary artery smooth muscle and endothelial cells. |
1999 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:10591667
|
Yokoyama S et al. |
Suppression of rat liver tumorigenesis by 25-hydroxycholesterol and all-trans retinoic acid: differentiation therapy for hepatocellular carcinoma. |
1999 |
Int. J. Oncol. |
pmid:10427141
|
Gauthier B et al. |
Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1. |
1999 |
J. Lipid Res. |
pmid:10393213
|
Aikawa K et al. |
Inhibition of cholesteryl ester formation in macrophages by azole antimycotics. |
1999 |
Biochem. Pharmacol. |
pmid:10424763
|
Ravid T et al. |
The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
2000 |
J. Biol. Chem. |
pmid:10964918
|
Spitsen GM et al. |
In nonhepatic cells, cholesterol 7alpha-hydroxylase induces the expression of genes regulating cholesterol biosynthesis, efflux, and homeostasis. |
2000 |
J. Lipid Res. |
pmid:10946023
|
Yang L and Sinensky MS |
25-Hydroxycholesterol activates a cytochrome c release-mediated caspase cascade. |
2000 |
Biochem. Biophys. Res. Commun. |
pmid:11095949
|
Norlin M et al. |
Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A). |
2000 |
J. Biol. Chem. |
pmid:10882719
|
Chiao YC et al. |
Direct effects of propylthiouracil on testosterone secretion in rat testicular interstitial cells. |
2000 |
Br. J. Pharmacol. |
pmid:10928947
|
Li-Hawkins J et al. |
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. |
2000 |
J. Biol. Chem. |
pmid:10748047
|
Mailhot G et al. |
Influence of the in vivo calcium status on cellular calcium homeostasis and the level of the calcium-binding protein calreticulin in rat hepatocytes. |
2000 |
Endocrinology |
pmid:10698163
|
Nes WD et al. |
Identification of the lipophilic factor produced by macrophages that stimulates steroidogenesis. |
2000 |
Endocrinology |
pmid:10698170
|
Ridgway ND |
Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin. |
2000 |
Biochim. Biophys. Acta |
pmid:10760463
|
Rusiñol AE et al. |
Isolation of a somatic cell mutant resistant to the induction of apoptosis by oxidized low density lipoprotein. |
2000 |
J. Biol. Chem. |
pmid:10702300
|
Choi JW and Choi HS |
The regulatory effects of thyroid hormone on the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase. |
2000 |
Endocr. Res. |
pmid:10711719
|
Hanley K et al. |
Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. |
2000 |
J. Invest. Dermatol. |
pmid:10692116
|
Dushkin MI et al. |
[Effect of 25-hydroxycholesterol and progesterone on esterification of cholesterol, viscosity, and protein-lipid interactions in macrophage membranes]. |
2000 |
Biull Eksp Biol Med |
pmid:10732231
|
O'Brien NM et al. |
Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals. |
2000 |
Biochem. Soc. Trans. |
pmid:10816093
|
Flach J et al. |
The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. |
2000 |
Biochem. Biophys. Res. Commun. |
pmid:10733934
|
Li D and Spencer TA |
Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. |
2000 |
Steroids |
pmid:10978732
|
Matsumoto K et al. |
Effects of hypoxia on cholesterol metabolism in human monocyte-derived macrophages. |
2000 |
Life Sci. |
pmid:11057758
|