| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Molowa DT and Cimis GM | Co-ordinate regulation of low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase and synthase gene expression in HepG2 cells. | 1989 | Biochem. J. | pmid:2569863 |
| Kocsis JF and Carsia RV | Steroidogenic properties of isolated turkey adrenocortical cells. | 1989 | Domest. Anim. Endocrinol. | pmid:2543538 |
| Smith CJ et al. | The response of large and small luteal cells from the pregnant rat to substrates and secretagogues. | 1989 | Biol. Reprod. | pmid:2560405 |
| Saragüeta P et al. | Insulin regulation of steroidogenic activity in rat culture luteal cells. | 1989 | J. Steroid Biochem. | pmid:2468046 |
| Wade DP et al. | Regulation of low-density-lipoprotein-receptor mRNA by insulin in human hepatoma Hep G2 cells. | 1989 | Eur. J. Biochem. | pmid:2471639 |
| Lynn WS et al. | Intracellular Ca2+ and cytotoxicity. | 1989 Sep-Oct | Arch. Environ. Health | pmid:2573316 |
| Leonard S et al. | Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21. | 1990 | J. Biol. Chem. | pmid:2180959 |
| Seillan C | Oxysterol mediated changes in fatty acid distribution and lipid synthesis in cultured bovine aortic smooth muscle cells. | 1990 | Lipids | pmid:2110280 |
| Weber H et al. | Dietary protein restriction stress and adrenocortical function: evidence for transient and long-term induction of enhanced cellular function. | 1990 | Endocrinology | pmid:2174347 |
| Roby KF and Terranova PF | Effects of tumor necrosis factor-alpha in vitro on steroidogenesis of healthy and atretic follicles of the rat: theca as a target. | 1990 | Endocrinology | pmid:2109690 |
| Boyce S et al. | Reconstructed skin from cultured human keratinocytes and fibroblasts on a collagen-glycosaminoglycan biopolymer substrate. | 1990 | Skin Pharmacol. | pmid:2127678 |
| Gibson-Berry KL and Chase DJ | Continuous and pulsatile infusions of luteinizing hormone have identical effects on steroidogenic capacity and sensitivity of Leydig cells in rats passively immunized against gonadotropin-releasing hormone. | 1990 | Endocrinology | pmid:1693567 |
| Ludes B et al. | Increased immunogenicity of human renal carcinoma cells following treatment with cholesterol derivatives. | 1990 | Eur. Urol. | pmid:2311641 |
| Rodriguez-Lafrasse C et al. | Abnormal cholesterol metabolism in imipramine-treated fibroblast cultures. Similarities with Niemann-Pick type C disease. | 1990 | Biochim. Biophys. Acta | pmid:2317521 |
| Patel NT and Thompson EB | Human oxysterol-binding protein. I. Identification and characterization in liver. | 1990 | J. Clin. Endocrinol. Metab. | pmid:2229319 |
| Panini SR et al. | Defective elongation of fatty acids in a recessive 25-hydroxycholesterol-resistant mutant cell line. | 1990 | J. Biol. Chem. | pmid:2117604 |
| Mazzone T et al. | Relation of growth- and sterol-related regulatory pathways for low density lipoprotein receptor gene expression. | 1990 | J. Biol. Chem. | pmid:2180958 |
| Guyton JR et al. | Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region. | 1990 | Am. J. Pathol. | pmid:2201200 |
| Gu Y et al. | Inhibitory effect of gossypol on steroidogenic pathways in cultured bovine luteal cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2162666 |
| Saucier SE et al. | Oxygenation of desmosterol and cholesterol in cell cultures. | 1990 | J. Lipid Res. | pmid:2090711 |
| Battista PJ et al. | Differential control of placental lactogen release and progesterone production by ovine placental tissue in vitro. | 1990 Jul-Aug | Placenta | pmid:2235915 |
| Gaffney DK et al. | Cholesterol content but not plasma membrane fluidity influences the susceptibility of L1210 leukemia cells to merocyanine 540-sensitized irradiation. | 1991 | Photochem. Photobiol. | pmid:1798749 |
| Gu Y et al. | Gossypolone suppresses progesterone synthesis in bovine luteal cells. | 1991 | J. Steroid Biochem. Mol. Biol. | pmid:2064986 |
| Hidaka Y et al. | Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. | 1991 | J. Biol. Chem. | pmid:1649182 |
| Bansal N et al. | Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents. | 1991 | FASEB J. | pmid:2004665 |
| Chakrabarti R and Engleman EG | Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation. | 1991 | J. Biol. Chem. | pmid:1712015 |
| Leighton JK et al. | Activation of the silent endogenous cholesterol-7-alpha-hydroxylase gene in rat hepatoma cells: a new complementation group having resistance to 25-hydroxycholesterol. | 1991 | Mol. Cell. Biol. | pmid:2005896 |
| Zhou Q et al. | The effect of 25-hydroxycholesterol on accumulation of intracellular calcium. | 1991 | Cell Calcium | pmid:1834342 |
| Talavera F and Menon KM | Studies on rat luteal cell response to insulin-like growth factor I (IGF-I): identification of a specific cell membrane receptor for IGF-I in the luteinized rat ovary. | 1991 | Endocrinology | pmid:1651848 |
| Dawson PA et al. | Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1991 | J. Biol. Chem. | pmid:1673968 |
| Dharmarajan AM et al. | Estradiol regulation of the rabbit corpus luteum: in vivo and in vitro studies. | 1991 | Endocrinology | pmid:2036954 |
| Wada A et al. | Expression of functional bovine cholesterol side chain cleavage cytochrome P450 (P450scc) in Escherichia coli. | 1991 | Arch. Biochem. Biophys. | pmid:1929405 |
| Constantino CX et al. | Insulin-like growth factor-I stimulates steroidogenesis in rabbit luteal cells. | 1991 | Endocrinology | pmid:2004596 |
| Ng LL and Davies JE | HMG CoA reductase inhibitors affect Na(+)-H+ antiport activity in human lymphoblasts. | 1991 | Am. J. Physiol. | pmid:1659206 |
| Taylor FR et al. | A proteolytic fragment of the oxysterol receptor which retains oxysterol binding activity. | 1991 | Arch. Biochem. Biophys. | pmid:1898049 |
| Zetterberg A and Larsson O | Coordination between cell growth and cell cycle transit in animal cells. | 1991 | Cold Spring Harb. Symp. Quant. Biol. | pmid:1819483 |
| Budd TJ et al. | Characterization of the LDL receptor in rat promegakaryoblasts in culture. | 1991 | Biosci. Rep. | pmid:1863711 |
| de la Llosa-Hermier MP et al. | Evidence for modulation of progesterone secretion by calcium and protein kinase C activators in ovine chorionic cells. | 1991 Sep-Oct | Placenta | pmid:1775444 |
| Taylor FR | Correlation among oxysterol potencies in the regulation of the degradation of 3-hydroxy-3-methylglutaryl CoA reductase, the repression of 3-hydroxy-3-methylglutaryl CoA synthase and affinities for the oxysterol receptor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1352965 |
| Tam SP and Ramharack R | The effect of 25-hydroxycholesterol on the regulation of apolipoprotein E mRNA levels and secretion in the human hepatoma HepG2. | 1992 | Atherosclerosis | pmid:1329783 |
| Chase DJ et al. | Maintenance or stimulation of steroidogenic enzymes and testosterone production in rat Leydig cells by continuous and pulsatile infusions of luteinizing hormone during passive immunization against gonadotrophin-releasing hormone. | 1992 | J. Reprod. Fertil. | pmid:1404082 |
| Kawamura K and Kummerow FA | Effect of 25-hydroxycholesterol on cytotoxicity and prostacyclin production in cultured human umbilical arterial endothelial cells. | 1992 | Eicosanoids | pmid:1419077 |
| Ridgway ND et al. | Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding. | 1992 | J. Cell Biol. | pmid:1730758 |
| Peffley DM | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control. | 1992 | Somat. Cell Mol. Genet. | pmid:1546367 |
| Izhar M et al. | Bovine placental progesterone synthesis: comparison of first and second trimesters of gestation. | 1992 | Biol. Reprod. | pmid:1591339 |
| Dorset DL | Binary phase behavior of angiotoxic oxidized cholesterols with cholesterol. | 1992 | Biochim. Biophys. Acta | pmid:1511006 |
| Begum-Hasan J and Murphy BE | Influence of 19-nortestosterone and androgens on progesterone biosynthetic enzymes in early human placental explants. | 1992 | J. Steroid Biochem. Mol. Biol. | pmid:1525044 |
| Tuckey RC | Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates. | 1992 | J. Steroid Biochem. Mol. Biol. | pmid:1525048 |
| Dahl NK et al. | Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol. | 1992 | J. Biol. Chem. | pmid:1537866 |
| Chun KT and Simoni RD | The role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1992 | J. Biol. Chem. | pmid:1740463 |