| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Medina MW et al. | Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. | 2011 | PLoS ONE | pmid:21559365 |
| Wang Y et al. | Nifedipine protects INS-1 β-cell from high glucose-induced ER stress and apoptosis. | 2011 | Int J Mol Sci | pmid:22174617 |
| Bhushan S et al. | Uropathogenic E. coli induce different immune response in testicular and peritoneal macrophages: implications for testicular immune privilege. | 2011 | PLoS ONE | pmid:22164293 |
| Shan PF et al. | Apelin attenuates the osteoblastic differentiation of vascular smooth muscle cells. | 2011 | PLoS ONE | pmid:21437254 |
| Jo Y et al. | Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2011 | J. Biol. Chem. | pmid:21343306 |
| Nantia EA et al. | Effects of the methanol extract of Basella alba L (Basellaceae) on steroid production in Leydig cells. | 2011 | Int J Mol Sci | pmid:21339992 |
| Sonawane PJ et al. | Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension. | 2011 | PLoS ONE | pmid:21304971 |
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| Lappano R et al. | The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes. | 2011 | PLoS ONE | pmid:21304949 |
| Keller M et al. | Inflammatory-induced hibernation in the fetus: priming of fetal sheep metabolism correlates with developmental brain injury. | 2011 | PLoS ONE | pmid:22242129 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Bai Q et al. | Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells. | 2011 | Atherosclerosis | pmid:21146170 |
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| Zhong W et al. | OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. | 2011 | Exp. Cell Res. | pmid:21669198 |
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| Liu C et al. | Oxysterols direct B-cell migration through EBI2. | 2011 | Nature | pmid:21796211 |
| Aye IL et al. | Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. | 2011 | Placenta | pmid:21208656 |
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| Aye IL et al. | Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. | 2010 | Biochim. Biophys. Acta | pmid:20570635 |
| Ullrich C et al. | Effects of cholesterol and its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices. | 2010 | Pharmacology | pmid:20571288 |
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| Chang LL et al. | Effects and mechanisms of nonylphenol on corticosterone release in rat zona fasciculata-reticularis cells. | 2010 | Toxicol. Sci. | pmid:20837582 |
| Shoemaker JE et al. | Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk. | 2010 | BMC Syst Biol | pmid:20579396 |
| Menon KM et al. | Molecular regulation of gonadotropin receptor expression: relationship to sterol metabolism. | 2010 | Mol. Cell. Endocrinol. | pmid:20570710 |
| Borthwick F et al. | Overexpression of STARD3 in human monocyte/macrophages induces an anti-atherogenic lipid phenotype. | 2010 | Clin. Sci. | pmid:20491656 |
| Hartman IZ et al. | Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets. | 2010 | J. Biol. Chem. | pmid:20406816 |
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| Amirak E et al. | Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19958749 |
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| Ando H et al. | Low-density lipoprotein and oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase in vitro. | 2010 | Biochim. Biophys. Acta | pmid:20045741 |
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| Schüle R et al. | Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. | 2010 | J. Lipid Res. | pmid:19812052 |
| Perales S et al. | Fish oil supplementation reverses the effect of cholesterol on apoptotic gene expression in smooth muscle cells. | 2010 | Lipids Health Dis | pmid:20630092 |
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