| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Taylor FR | Correlation among oxysterol potencies in the regulation of the degradation of 3-hydroxy-3-methylglutaryl CoA reductase, the repression of 3-hydroxy-3-methylglutaryl CoA synthase and affinities for the oxysterol receptor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1352965 |
| Kusuhara H et al. | Effect of 25-hydroxycholesterol on cholesteryl ester formation in Caco-2 cells. | 1992 | Lipids | pmid:1630282 |
| Ridgway ND et al. | Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding. | 1992 | J. Cell Biol. | pmid:1730758 |
| Peffley DM | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control. | 1992 | Somat. Cell Mol. Genet. | pmid:1546367 |
| Izhar M et al. | Bovine placental progesterone synthesis: comparison of first and second trimesters of gestation. | 1992 | Biol. Reprod. | pmid:1591339 |
| Begum-Hasan J and Murphy BE | Influence of 19-nortestosterone and androgens on progesterone biosynthetic enzymes in early human placental explants. | 1992 | J. Steroid Biochem. Mol. Biol. | pmid:1525044 |
| Tuckey RC | Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates. | 1992 | J. Steroid Biochem. Mol. Biol. | pmid:1525048 |
| Chun KT and Simoni RD | The role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1992 | J. Biol. Chem. | pmid:1740463 |
| Murphy BD et al. | Control of luteal function in the mink (Mustela vison). | 1993 | J. Reprod. Fertil. Suppl. | pmid:8229925 |
| Larsson O | Cell cycle-specific growth inhibition of human breast cancer cells induced by metabolic inhibitors. | 1993 | Glycobiology | pmid:8286860 |
| Dahl NK et al. | Abnormal regulation of low density lipoprotein-sensitive events in a cholesterol transport mutant. | 1993 | J. Biol. Chem. | pmid:8349588 |
| Guo X et al. | Inhibition of hepatocyte gap junctional communication by 25-hydroxycholesterol may be mediated through free radicals. | 1993 | Eur. J. Pharmacol. | pmid:8181541 |
| Stephan ZF and Yurachek EC | Rapid fluorometric assay of LDL receptor activity by DiI-labeled LDL. | 1993 | J. Lipid Res. | pmid:8381454 |
| Pinkerton FD et al. | Differing effects of three oxysterols on low density lipoprotein metabolism in HepG2 cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8391799 |
| Furukawa S and Hirano T | Rapid stimulation of apolipoprotein B secretion by oleate is not associated with cholesteryl ester biosynthesis in HepG2 cells. | 1993 | Biochim. Biophys. Acta | pmid:8399324 |
| Kraemer R et al. | Induction of basic fibroblast growth factor mRNA and protein synthesis in smooth muscle cells by cholesteryl ester enrichment and 25-hydroxycholesterol. | 1993 | J. Biol. Chem. | pmid:8463321 |
| Jiang G et al. | Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase. | 1993 | J. Biol. Chem. | pmid:7685352 |
| Tuckey RC and Cameron KJ | Catalytic properties of cytochrome P-450scc purified from the human placenta: comparison to bovine cytochrome P-450scc. | 1993 | Biochim. Biophys. Acta | pmid:8490050 |
| Choi JW et al. | Inhibition of protein synthesis in baby-hamster kidney cells blocks oxysterol-mediated suppression of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA at a post-transcriptional level. | 1993 | Biochem. J. | pmid:8280085 |
| Parker RA et al. | Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1993 | J. Biol. Chem. | pmid:8388388 |
| Lund E et al. | 24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. | 1993 | Biochim. Biophys. Acta | pmid:8443234 |
| Kocarek TA et al. | Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes. | 1993 | Toxicol. Appl. Pharmacol. | pmid:8511800 |
| Chen H et al. | Cholesterol and sphingomyelin syntheses are regulated independently in cultured human intestinal cells, CaCo-2: role of membrane cholesterol and sphingomyelin content. | 1993 | J. Lipid Res. | pmid:8301234 |
| Fornas E et al. | Cholesterol and 25-hydroxycholesterol retention in specimens of liver and aorta prepared for electron microscopy. I. Standard fixation methods and metabolism of the labeled sterols. | 1993 | Lipids | pmid:8246693 |
| Fornas E et al. | Cholesterol and 25-hydroxycholesterol retention in specimens of liver and aorta prepared for electron microscopy. II. Effect of filipin, osmium, digitonin and saponin. | 1993 | Lipids | pmid:8246694 |
| Carlberg M and Larsson O | Role of N-linked glycosylation in cell-cycle progression and initiation of DNA synthesis in tumor-transformed human fibroblasts. | 1993 Jan-Feb | Anticancer Res. | pmid:8476209 |
| Larsson O and Blegen H | Regulatory role of mevalonate in the growth of normal and neoplastic human mammary epithelial cells. | 1993 Jul-Aug | Anticancer Res. | pmid:8352528 |
| Dahl NK et al. | A second complementation class of cholesterol transport mutants with a variant Niemann-Pick type C phenotype. | 1994 | J. Lipid Res. | pmid:7852861 |
| Patel SC et al. | 25-Hydroxycholesterol induces reorganization of lysosomes in normal but not Niemann-Pick disease type C astrocytes. | 1994 | Neuroreport | pmid:7865759 |
| Zhou Q and Kummerow FA | The influence of 25-hydroxycholesterol on phosphatidylinositol content in cultured smooth muscle cells. | 1994 | Proc. Soc. Exp. Biol. Med. | pmid:8208734 |
| Tuckey RC et al. | Cytochrome P-450scc activity and substrate supply in human placental trophoblasts. | 1994 | Mol. Cell. Endocrinol. | pmid:7859918 |
| Lee KA and Bahr JM | Utilization of substrates for testosterone and estradiol-17 beta production by small follicles of the chicken ovary. | 1994 | Domest. Anim. Endocrinol. | pmid:7956177 |
| Larsen SD et al. | Design and synthesis of seco-oxysterol analogs as potential inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene transcription. | 1994 | J. Med. Chem. | pmid:8057282 |
| Ayala-Torres S et al. | Oxysterol sensitive and resistant lymphoid cells: correlation with regulation of cellular nucleic acid binding protein mRNA. | 1994 | J. Steroid Biochem. Mol. Biol. | pmid:8142309 |
| Shiratori Y et al. | Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase. | 1994 | J. Biol. Chem. | pmid:8157665 |
| Taniguchi T et al. | Regulation of cholesterol 7 alpha-hydroxylase gene expression in Hep-G2 cells. Effect of serum, bile salts, and coordinate and noncoordinate regulation with other sterol-responsive genes. | 1994 | J. Biol. Chem. | pmid:8144506 |
| Aikawa K et al. | Structure-specific inhibition of lysosomal cholesterol transport in macrophages by various steroids. | 1994 | Biochim. Biophys. Acta | pmid:8025122 |
| Watson KE et al. | TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. | 1994 | J. Clin. Invest. | pmid:8182141 |
| Ellsworth JL et al. | Ketoconazole and 25-hydroxycholesterol produce reciprocal changes in the rate of transcription of the human LDL receptor gene. | 1994 | Biochim. Biophys. Acta | pmid:8305487 |
| Johnson KA et al. | In vivo formation of 25-hydroxycholesterol from endogenous cholesterol after a single meal, dietary cholesterol challenge. | 1994 | J. Lipid Res. | pmid:7897321 |
| Wilson WK et al. | Inhibitors of sterol synthesis. Effects of fluorine substitution at carbon atom 25 of cholesterol on its spectral and chromatographic properties and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells. | 1994 | Steroids | pmid:8073444 |
| Srivastava RK and Van der Kraak G | Insulin as an amplifier of gonadotropin action on steroid production: mechanisms and sites of action in goldfish prematurational full-grown ovarian follicles. | 1994 | Gen. Comp. Endocrinol. | pmid:7926656 |
| Küçük O et al. | Inhibition of cytolytic T lymphocyte activity by oxysterols. | 1994 | Lipids | pmid:7815901 |
| Björkhem I et al. | Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8078928 |
| Li QT and Das NP | Comparison of the effects of cholesterol and oxysterols on phospholipid bilayer microheterogeneity: a study of fluorescence lifetime distributions. | 1994 | Arch. Biochem. Biophys. | pmid:7986094 |
| Hirai A et al. | Regulation of sterol carrier protein 2 (SCP2) gene expression in rat peritoneal macrophages during foam cell formation. A key role for free cholesterol content. | 1994 | J. Clin. Invest. | pmid:7989577 |
| Cooper AD et al. | Characteristics and regulation of bile salt synthesis and secretion by human hepatoma HepG2 cells. | 1994 | Hepatology | pmid:7982652 |
| Toll A et al. | 7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase. | 1994 | Eur. J. Biochem. | pmid:7925343 |
| Breuer O and Björkhem I | Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. | 1995 | J. Biol. Chem. | pmid:7657597 |
| Ranheim T et al. | Effect of a coffee lipid (cafestol) on regulation of lipid metabolism in CaCo-2 cells. | 1995 | J. Lipid Res. | pmid:8576635 |