| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang F et al. | Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis. | 2012 | Cardiovasc. Res. | pmid:21979142 |
| Gil G et al. | Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. | 1985 | Cell | pmid:3995584 |
| Kwon HJ et al. | Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. | 2009 | Cell | pmid:19563754 |
| Dang EV et al. | Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. | 2017 | Cell | pmid:29033131 |
| Südhof TC et al. | 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. | 1987 | Cell | pmid:3030558 |
| Brahimi F et al. | Control of apolipoprotein E secretion in the human hepatoma cell line KYN-2. | 2001 | Cell Biochem. Funct. | pmid:11223871 |
| Rosca AM et al. | Cardiomyocyte apoptosis in ischaemia-reperfusion due to the exogenous oxidants at the time of reperfusion. | 2012 | Cell Biol. Int. | pmid:22994946 |
| Lemaire-Ewing S et al. | Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. | 2005 | Cell Biol. Toxicol. | pmid:16142584 |
| O'Callaghan YC et al. | Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. | 2001 | Cell Biol. Toxicol. | pmid:11499696 |
| Gueguen Y et al. | Control of apolipoprotein E secretion by 25-hydroxycholesterol and proinflammatory cytokines in the human astrocytoma cell line CCF-STTG1. | 2001 | Cell Biol. Toxicol. | pmid:11693580 |
| Lemaire-Ewing S et al. | 7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent. | 2009 | Cell Biol. Toxicol. | pmid:18317936 |
| Zhou Q et al. | The effect of 25-hydroxycholesterol on accumulation of intracellular calcium. | 1991 | Cell Calcium | pmid:1834342 |
| Koo MS et al. | Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages. | 2012 | Cell Commun. Signal | pmid:22280836 |
| Gong Y et al. | Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. | 2006 | Cell Metab. | pmid:16399501 |
| Chen W et al. | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. | 2007 | Cell Metab. | pmid:17189208 |
| Porstmann T et al. | SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. | 2008 | Cell Metab. | pmid:18762023 |
| Larsson O and Zetterberg A | Existence of a commitment program for mitosis in early G1 in tumour cells. | 1995 | Cell Prolif. | pmid:7833384 |
| Howe D and Heinzen RA | Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism. | 2006 | Cell. Microbiol. | pmid:16469060 |
| Ropero S et al. | Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes. | 2003 | Cell. Signal. | pmid:12401528 |
| Calleros L et al. | Low cell cholesterol levels increase NFkappaB activity through a p38 MAPK-dependent mechanism. | 2006 | Cell. Signal. | pmid:16806824 |
| Ohgane K et al. | Discovery of oxysterol-derived pharmacological chaperones for NPC1: implication for the existence of second sterol-binding site. | 2013 | Chem. Biol. | pmid:23521797 |
| Matsui M et al. | Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter. | 2010 | Chem. Biol. | pmid:21168770 |
| Taylor FR and Kandutsch AA | Oxysterol binding protein. | 1985 | Chem. Phys. Lipids | pmid:4064220 |
| Olivier E et al. | 25-Hydroxycholesterol induces both P2X7-dependent pyroptosis and caspase-dependent apoptosis in human skin model: New insights into degenerative pathways. | 2017 | Chem. Phys. Lipids | pmid:28599978 |
| Gregus M et al. | Non-aqueous capillary electrophoretic separation of cholesterol and 25-hydroxycholesterol after derivatization with Girard P reagent. | 2017 | Chem. Phys. Lipids | pmid:28583433 |
| Mintzer E et al. | Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes. | 2010 | Chem. Phys. Lipids | pmid:20471966 |
| Rakić B et al. | Bleomycin is a potent small-molecule inhibitor of hepatitis C virus replication. | 2006 | Chembiochem | pmid:16888741 |
| Feng TH et al. | Cholesterol modulation of the expression of mitochondrial aconitase in human prostatic carcinoma cells. | 2005 | Chin J Physiol | pmid:16201454 |
| Wu CA et al. | An evaluation of the mechanism of ABCA7 on cellular lipid release in ABCA7-HEC293 cell. | 2013 | Chin. Med. J. | pmid:23324282 |
| Tao JL et al. | Lipids-induced apoptosis is aggravated by acyl-coenzyme A: cholesterol acyltransferase inhibitor. | 2010 | Chin. Med. Sci. J. | pmid:20598228 |
| Zhou RH et al. | Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis. | 2004 | Circ. Res. | pmid:15271857 |
| Yeh M et al. | Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products. | 2004 | Circ. Res. | pmid:15388640 |
| Li Z et al. | Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. | 2017 | Circulation | pmid:28794002 |
| Montecucco F et al. | The immune response is involved in atherosclerotic plaque calcification: could the RANKL/RANK/OPG system be a marker of plaque instability? | 2007 | Clin. Dev. Immunol. | pmid:18320012 |
| Elsegood CL et al. | Binding and uptake of chylomicron remnants by primary and THP-1 human monocyte-derived macrophages: determination of binding proteins. | 2001 | Clin. Sci. | pmid:11473484 |
| Borthwick F et al. | Overexpression of STARD3 in human monocyte/macrophages induces an anti-atherogenic lipid phenotype. | 2010 | Clin. Sci. | pmid:20491656 |
| Zetterberg A and Larsson O | Coordination between cell growth and cell cycle transit in animal cells. | 1991 | Cold Spring Harb. Symp. Quant. Biol. | pmid:1819483 |
| Ishii H et al. | Analysis of the 22-NBD-cholesterol transfer between liposome membranes and its relation to the intermembrane exchange of 25-hydroxycholesterol. | 2010 | Colloids Surf B Biointerfaces | pmid:20122819 |
| Zhang L et al. | Characterization of the estrogenic response to genistein in Japanese medaka (Oryzias latipes). | 2002 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:12106897 |
| Parish EJ et al. | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by side-chain oxysterols and their derivatives. | 1999 | Crit. Rev. Biochem. Mol. Biol. | pmid:10517646 |
| Catalgol B and Kartal Ozer N | Lipid rafts and redox regulation of cellular signaling in cholesterol induced atherosclerosis. | 2010 | Curr Cardiol Rev | pmid:22043207 |
| Dasari B et al. | Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. | 2013 | Curr. Eye Res. | pmid:23841471 |
| Malvitte L et al. | Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol. | 2008 | Curr. Eye Res. | pmid:18798080 |
| Joffre C et al. | Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. | 2007 | Curr. Eye Res. | pmid:17453947 |
| Prunet C et al. | Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients. | 2006 | Cytometry A | pmid:16604541 |
| Katz R et al. | Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA). | 2009 | Diabetes | pmid:19136658 |
| Ferderbar S et al. | Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. | 2007 | Diabetes Metab. Res. Rev. | pmid:16634125 |
| Lee KA and Bahr JM | Utilization of substrates for testosterone and estradiol-17 beta production by small follicles of the chicken ovary. | 1994 | Domest. Anim. Endocrinol. | pmid:7956177 |
| Kocsis JF and Carsia RV | Steroidogenic properties of isolated turkey adrenocortical cells. | 1989 | Domest. Anim. Endocrinol. | pmid:2543538 |
| Shenoy SD et al. | CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. | 2004 | Drug Metab. Dispos. | pmid:14709622 |