| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu PL et al. | Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats. | 2009 | J. Cell. Biochem. | pmid:19639602 |
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| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |
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| Choi YK et al. | 25-hydroxycholesterol induces mitochondria-dependent apoptosis via activation of glycogen synthase kinase-3beta in PC12 cells. | 2008 | Free Radic. Res. | pmid:18569012 |
| DeBarber AE et al. | Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol. | 2008 | Anal. Biochem. | pmid:18555788 |
| Porstmann T et al. | SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. | 2008 | Cell Metab. | pmid:18762023 |
| Lange Y et al. | Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. | 2008 | J. Biol. Chem. | pmid:18024962 |
| Yan D et al. | OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. | 2008 | J. Biol. Chem. | pmid:17991739 |
| Gévry N et al. | Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues. | 2008 | J. Lipid Res. | pmid:18272928 |
| Farquhar MJ and McKeating JA | Primary hepatocytes as targets for hepatitis C virus replication. | 2008 | J. Viral Hepat. | pmid:19087224 |
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| Zerbinatti CV et al. | Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein. | 2008 | Mol Neurodegener | pmid:18348724 |
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| Malvitte L et al. | Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol. | 2008 | Curr. Eye Res. | pmid:18798080 |
| Yanagita T et al. | Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells. | 2008 | Lipids Health Dis | pmid:18925970 |
| Infante RE et al. | Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. | 2008 | J. Biol. Chem. | pmid:17989073 |
| Ma Y et al. | 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway. | 2008 | Am. J. Physiol. Endocrinol. Metab. | pmid:18854425 |
| Lizardo-Daudt HM et al. | Cadmium chloride-induced disruption of testicular steroidogenesis in rainbow trout, Oncorhynchus mykiss. | 2008 | Arch. Environ. Contam. Toxicol. | pmid:18040592 |
| Wang PY et al. | The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBP. | 2008 | J. Biol. Chem. | pmid:18165705 |
| Reschly EJ et al. | Ligand specificity and evolution of liver X receptors. | 2008 | J. Steroid Biochem. Mol. Biol. | pmid:18395439 |
| Kang MA et al. | Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. | 2007 | Life Sci. | pmid:17161435 |
| Kosztáczky B et al. | Leptin stimulates endogenous cholesterol synthesis in human monocytes: New role of an old player in atherosclerotic plaque formation. Leptin-induced increase in cholesterol synthesis. | 2007 | Int. J. Biochem. Cell Biol. | pmid:17560160 |
| Chen W et al. | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. | 2007 | Cell Metab. | pmid:17189208 |
| Han JH et al. | Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition. | 2007 | Brain Res. | pmid:17224136 |
| Molina S et al. | The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus. | 2007 | J. Hepatol. | pmid:17156886 |
| Wyles JP et al. | Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization. | 2007 | Exp. Cell Res. | pmid:17350617 |
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| Wong J et al. | Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. | 2007 | Lipids Health Dis | pmid:17408498 |
| Wang L et al. | Ribonucleic acid binding protein-mediated regulation of luteinizing hormone receptor expression in granulosa cells: relationship to sterol metabolism. | 2007 | Mol. Endocrinol. | pmid:17550979 |
| Vejux A et al. | Cytotoxic oxysterols induce caspase-independent myelin figure formation and caspase-dependent polar lipid accumulation. | 2007 | Histochem. Cell Biol. | pmid:17226048 |
| Storbeck KH et al. | Evidence for the functional role of residues in the B'-C loop of baboon cytochrome P450 side-chain cleavage (CYP11A1) obtained by site-directed mutagenesis, kinetic analysis and homology modelling. | 2007 | J. Steroid Biochem. Mol. Biol. | pmid:17081746 |
| Erridge C et al. | 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages. | 2007 | Free Radic. Res. | pmid:17364953 |
| Tamehiro N et al. | Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. | 2007 | J. Biol. Chem. | pmid:17526932 |
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| Lee PC et al. | Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells. | 2007 | J. Lipid Res. | pmid:17586788 |
| Suchanek M et al. | The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. | 2007 | Biochem. J. | pmid:17428193 |
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| Kallin A et al. | SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma. | 2007 | J. Lipid Res. | pmid:17452746 |
| Joffre C et al. | Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. | 2007 | Curr. Eye Res. | pmid:17453947 |
| Umetani M et al. | 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. | 2007 | Nat. Med. | pmid:17873880 |
| Risé P et al. | Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. | 2007 | Eur. J. Pharmacol. | pmid:17655842 |
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