| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lemaire-Ewing S et al. | Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. | 2005 | Cell Biol. Toxicol. | pmid:16142584 |
| Raith K et al. | A new LC/APCI-MS method for the determination of cholesterol oxidation products in food. | 2005 | J Chromatogr A | pmid:15844526 |
| Li D and Mehta JL | Oxidized LDL, a critical factor in atherogenesis. | 2005 | Cardiovasc. Res. | pmid:16253212 |
| Feng TH et al. | Cholesterol modulation of the expression of mitochondrial aconitase in human prostatic carcinoma cells. | 2005 | Chin J Physiol | pmid:16201454 |
| Yu-Poth S et al. | Long-chain polyunsaturated fatty acids upregulate LDL receptor protein expression in fibroblasts and HepG2 cells. | 2005 | J. Nutr. | pmid:16251608 |
| Neumeier M et al. | Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16023994 |
| Bouchard C et al. | Post-transcriptional regulation of apoC-I synthesis and secretion in human HepG2 cells. | 2005 | Atherosclerosis | pmid:15694932 |
| Bottero S et al. | In vivo and in vitro exposures of carp and carp tissues to graded concentrations of endocrine disrupting chemicals. | 2005 | Ann. N. Y. Acad. Sci. | pmid:15891032 |
| Adams CM et al. | Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. | 2004 | J. Biol. Chem. | pmid:15452130 |
| Dubuc G et al. | Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15178557 |
| Gerber R et al. | Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. | 2004 | Anal. Biochem. | pmid:15136164 |
| Roitelman J et al. | Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity. | 2004 | J. Biol. Chem. | pmid:14627708 |
| Rusiñol AE et al. | AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis. | 2004 | J. Biol. Chem. | pmid:14559920 |
| Yang Y et al. | Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1). | 2004 | Biochem. Biophys. Res. Commun. | pmid:15249218 |
| Hall AM et al. | 25-hydroxycholesterol acts in the Golgi compartment to induce degradation of tyrosinase. | 2004 | Pigment Cell Res. | pmid:15250942 |
| Demoulin JB et al. | Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins. | 2004 | J. Biol. Chem. | pmid:15213220 |
| Desaint S et al. | NFY interacts with the promoter region of two genes involved in the rat peroxisomal fatty acid beta-oxidation: the multifunctional protein type 1 and the 3-ketoacyl-CoA B thiolase. | 2004 | Lipids Health Dis | pmid:15046640 |
| Yu L et al. | Sterol regulation of scavenger receptor class B type I in macrophages. | 2004 | J. Lipid Res. | pmid:14967816 |
| Ripollés Piquer B et al. | Effect of LPS on basal and induced apo E secretion by 25-OH chol and 9cRA in differentiated CaCo-2. | 2004 | J. Cell. Biochem. | pmid:14991770 |
| Mullen E et al. | Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells. | 2004 | J. Nutr. | pmid:15514256 |
| Schmuth M et al. | The effect of LXR activators on AP-1 proteins in keratinocytes. | 2004 | J. Invest. Dermatol. | pmid:15191540 |
| Annalora A et al. | Rat cytochrome P450C24 (CYP24A1) and the role of F249 in substrate binding and catalytic activity. | 2004 | Arch. Biochem. Biophys. | pmid:15111121 |
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| King SR et al. | Oxysterols regulate expression of the steroidogenic acute regulatory protein. | 2004 | J. Mol. Endocrinol. | pmid:15072555 |
| Gbaguidi GF and Agellon LB | The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer. | 2004 | Nucleic Acids Res. | pmid:14960721 |
| Yu-Poth S et al. | Conjugated linoleic acid upregulates LDL receptor gene expression in HepG2 cells. | 2004 | J. Nutr. | pmid:14704295 |
| Shenoy SD et al. | CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. | 2004 | Drug Metab. Dispos. | pmid:14709622 |
| Le Jossic-Corcos C et al. | Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15084352 |
| Du X et al. | Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum. | 2004 | J. Biol. Chem. | pmid:15317807 |
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| Akiba S et al. | Translocation of phospholipase A2 to membranes by oxidized LDL and hydroxyoctadecadienoic acid to contribute to cholesteryl ester formation. | 2004 | Biochim. Biophys. Acta | pmid:15522824 |
| Huang SH et al. | Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes. | 2004 | J. Cell. Biochem. | pmid:15034936 |
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| Tsai SC et al. | Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells. | 2003 | J. Cell. Biochem. | pmid:14635199 |
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| Wenz JJ and Barrantes FJ | Steroid structural requirements for stabilizing or disrupting lipid domains. | 2003 | Biochemistry | pmid:14640695 |
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| Ropero S et al. | Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes. | 2003 | Cell. Signal. | pmid:12401528 |
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| Lim HK et al. | Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line. | 2003 | Life Sci. | pmid:12527036 |
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| Rydberg EK et al. | Hypoxia increases 25-hydroxycholesterol-induced interleukin-8 protein secretion in human macrophages. | 2003 | Atherosclerosis | pmid:14612204 |
| Chang LL et al. | Effects of dehydroepiandrosterone on corticosterone release in rat zona fasciculata-reticularis cells. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:14615881 |
| Antonio V et al. | Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. | 2003 | Biochem. J. | pmid:12882648 |
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| Miura S et al. | Sterol-mediated regulation of hormone-sensitive lipase in 3T3-L1 adipocytes. | 2003 | Lipids | pmid:14506837 |
| Yoshida T et al. | Origin of oxysterols in hepatic bile of patients with biliary infection. | 2003 | Am. J. Gastroenterol. | pmid:14572579 |