MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Medina MW et al. | Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. | 2011 | PLoS ONE | pmid:21559365 |
Thorsell AG et al. | Comparative structural analysis of lipid binding START domains. | 2011 | PLoS ONE | pmid:21738568 |
Zhou T et al. | OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62. | 2011 | PLoS ONE | pmid:21698267 |
Shan PF et al. | Apelin attenuates the osteoblastic differentiation of vascular smooth muscle cells. | 2011 | PLoS ONE | pmid:21437254 |
Trousson A et al. | Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death. | 2009 | PLoS ONE | pmid:19956653 |
Jiang W et al. | Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis. | 2014 | PLoS ONE | pmid:25426949 |
Ren S et al. | Identification of novel regulatory cholesterol metabolite, 5-cholesten, 3β,25-diol, disulfate. | 2014 | PLoS ONE | pmid:25072708 |
Pachikian BD et al. | Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. | 2011 | PLoS ONE | pmid:21853118 |
Krycer JR et al. | Cholesterol homeostasis in two commonly used human prostate cancer cell-lines, LNCaP and PC-3. | 2009 | PLoS ONE | pmid:20041144 |
Solberg R et al. | Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs. | 2010 | PLoS ONE | pmid:20231903 |