| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen H et al. | Depletion and repopulation of Leydig cells in the testes of aging brown Norway rats. | 1996 | Endocrinology | pmid:8754773 |
| Jepson CA et al. | Down-regulation of hormone-sensitive lipase in sterol ester-laden J774.2 macrophages. | 1996 | Biochem. J. | pmid:8761468 |
| McGee TP et al. | Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis. | 1996 | J. Biol. Chem. | pmid:8810339 |
| Musanti R et al. | Inhibition of acyl-CoA: cholesterol acyltransferase decreases apolipoprotein B-100-containing lipoprotein secretion from HepG2 cells. | 1996 | J. Lipid Res. | pmid:8820097 |
| Lin CY and Morel DW | Esterification of oxysterols in human serum: effects on distribution and cellular uptake. | 1996 | J. Lipid Res. | pmid:8820112 |
| Verhagen JC et al. | Physical effects of biologically formed cholesterol oxidation products on lipid membranes investigated with fluorescence depolarization spectroscopy and electron spin resonance. | 1996 | J. Lipid Res. | pmid:8827521 |
| Nishio E and Watanabe Y | Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8831713 |
| Taniguchi S et al. | Dehydroepiandrosterone markedly inhibits the accumulation of cholesteryl ester in mouse macrophage J774-1 cells. | 1996 | Atherosclerosis | pmid:8879442 |
| Morel DW et al. | Comparison of the intracellular metabolism and trafficking of 25-hydroxycholesterol and cholesterol in macrophages. | 1996 | J. Lipid Res. | pmid:8895069 |
| Liza M et al. | Application of 2-hydroxypropyl-beta-cyclodextrin in the assay of acyl-CoA:cholesterol acyltransferase and neutral and acid cholesterol ester hydrolases. | 1996 | Lipids | pmid:8900462 |
| Pak YK | Serum response element-like sequences of the human low density lipoprotein receptor promoter: possible regulation sites for sterol-independent transcriptional activation. | 1996 | Biochem. Mol. Biol. Int. | pmid:8932516 |
| Nohturfft A et al. | Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8942999 |
| Bhuvaneswaran C et al. | Activation of acyl-CoA: cholesterol acyltransferase in rat liver microsomes by 25-hydroxycholesterol. | 1997 | Biochem. Pharmacol. | pmid:8960060 |
| Spicer LJ et al. | Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis. | 1996 | J. Endocrinol. | pmid:8994382 |
| Babischkin JS et al. | Estrogen stimulation of P450 cholesterol side-chain cleavage activity in cultures of human placental syncytiotrophoblasts. | 1997 | Biol. Reprod. | pmid:9002660 |
| Chiloeches A et al. | Effect of mevalonate availability on the association of G-protein alpha-subunits with the plasma membrane in GH4C1 cells. | 1997 | FEBS Lett. | pmid:9003808 |
| Lehmann JM et al. | Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. | 1997 | J. Biol. Chem. | pmid:9013544 |
| Warren JT and Gilbert LI | Metabolism in vitro of cholesterol and 25-hydroxycholesterol by the larval prothoracic glands of Manduca sexta. | 1996 Sep-Oct | Insect Biochem. Mol. Biol. | pmid:9014337 |
| Peffley DM and Gayen AK | Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. | 1997 | Arch. Biochem. Biophys. | pmid:9016820 |
| Bowling N et al. | LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins. | 1996 | J. Lipid Res. | pmid:9017510 |
| Baum CL et al. | Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion. | 1997 | J. Biol. Chem. | pmid:9045674 |
| Zhang J et al. | Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase. | 1997 | Biochim. Biophys. Acta | pmid:9059514 |
| Zhang J et al. | Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. | 1997 | Biochem. J. | pmid:9078259 |
| Liu Y et al. | Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory function for IL-8 production. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9081687 |
| Wohlfeil ER and Campbell WB | 25-Hydroxycholesterol enhances eicosanoid production in cultured bovine coronary artery endothelial cells by increasing prostaglandin G/H synthase-2. | 1997 | Biochim. Biophys. Acta | pmid:9084508 |
| Lala DS et al. | Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9144161 |
| Vanderhyden BC | Oocyte-secreted factors regulate granulosa cell steroidogenesis. | 1996 | Zygote | pmid:9153773 |
| McCourt MP et al. | X-ray crystal structure of cytotoxic oxidized cholesterols: 7-ketocholesterol and 25-hydroxycholesterol. | 1997 | J. Lipid Res. | pmid:9186918 |
| Harada K et al. | Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway. | 1997 | FEBS Lett. | pmid:9247143 |
| Zhang J et al. | 7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes. | 1997 | Eur. J. Biochem. | pmid:9249018 |
| Phelan KD and Mahler HR | Acute exposure to 25-hydroxy-cholesterol selectively reduces GABAb and not GABAa receptor-mediated synaptic inhibition. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9266831 |
| Ayala-Torres S et al. | Characteristics of 25-hydroxycholesterol-induced apoptosis in the human leukemic cell line CEM. | 1997 | Exp. Cell Res. | pmid:9281350 |
| Chang JY and Liu LZ | 25-Hydroxycholesterol causes death but does not prevent nerve growth factor-induced neurite outgrowth in PC12 cells. | 1997 | Neurochem. Int. | pmid:9308000 |
| Johnson BH et al. | Glucocorticoid/oxysterol-induced DNA lysis in human leukemic cells. | 1997 | J. Steroid Biochem. Mol. Biol. | pmid:9328208 |
| Lagace TA et al. | Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain. | 1997 | Biochem. J. | pmid:9337870 |
| Chang JY et al. | Establishment of two morphologically distinct PC12 cell lines resistant to 25-OH-cholesterol toxicity. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9344846 |
| Ares MP et al. | Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells. | 1997 | J. Lipid Res. | pmid:9374127 |
| Duan H et al. | Degradation of macrophage ApoE in a nonlysosomal compartment. Regulation by sterols. | 1997 | J. Biol. Chem. | pmid:9388269 |
| Miura S et al. | Cholesterol-mediated changes of neutral cholesterol esterase activity in macrophages. Mechanism for mobilization of cholesteryl esters in lipid droplets by HDL. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409290 |
| Suresh S et al. | Cellular cholesterol storage in the Niemann-Pick disease type C mouse is associated with increased expression and defective processing of apolipoprotein D. | 1998 | J. Neurochem. | pmid:9422368 |
| Nilsson J et al. | Lipoprotein-like phospholipid particles inhibit the smooth muscle cell cytotoxicity of lysophosphatidylcholine and platelet-activating factor. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9445250 |
| Carsia RV and McIlroy PJ | Dietary protein restriction stress in the domestic turkey (Meleagris gallopavo) induces hypofunction and remodeling of adrenal steroidogenic tissue. | 1998 | Gen. Comp. Endocrinol. | pmid:9446731 |
| Tatidis L et al. | Decreased feedback regulation of low density lipoprotein receptor activity by sterols in leukemic cells from patients with acute myelogenous leukemia. | 1997 | J. Lipid Res. | pmid:9458267 |
| Bertherat J | The nuclear receptor SF-1 (steroidogenic factor-1) is no longer an orphan. | 1998 | Eur. J. Endocrinol. | pmid:9461312 |
| Chang JY et al. | Neurotoxicity of 25-OH-cholesterol on NGF-differentiated PC12 cells. | 1998 | Neurochem. Res. | pmid:9482261 |
| Musatov MI et al. | [Effect of oxidized cholesterol derivatives on lymphokine stimulated differentiation of macrophages and primary allogenic mixed human lymphocyte culture]. | 1997 | Biull Eksp Biol Med | pmid:9483320 |
| Ridgway ND et al. | Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A. | 1998 | Biochim. Biophys. Acta | pmid:9487139 |
| Norlin M and Wikvall K | Biochemical characterization of the 7alpha-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes. | 1998 | Biochim. Biophys. Acta | pmid:9487148 |
| Ellsworth JL and Starr JR | Inhibition of acyl coenzyme A:cholesterol acyltransferase blocks esterification but not uptake of cholesterol in Caco-2 cells. | 1998 | Metab. Clin. Exp. | pmid:9500571 |
| Halvorsen B et al. | Effect of a coffee lipid (cafestol) on cholesterol metabolism in human skin fibroblasts. | 1998 | J. Lipid Res. | pmid:9555953 |
| Kaur M et al. | Receptor-Ck-dependent regulation of genes involved in the cell cycle. | 1998 | Mol. Cell. Biochem. | pmid:9562250 |
| Chang JY et al. | Neurotoxicity of 25-OH-cholesterol on sympathetic neurons. | 1998 | Brain Res. Bull. | pmid:9566506 |
| Lin HS et al. | Synthesis of 4 alpha-(2-propenyl)-5,6-secocholestan-3 alpha-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4 alpha-(2-propenyl)-5 alpha-cholestan-3 alpha-ol. | 1998 | Steroids | pmid:9589554 |
| Chang JY and Liu LZ | Neurotoxicity of cholesterol oxides on cultured cerebellar granule cells. | 1998 | Neurochem. Int. | pmid:9596554 |
| Grøndahl C et al. | Meiosis-activating sterol promotes resumption of meiosis in mouse oocytes cultured in vitro in contrast to related oxysterols. | 1998 | Biol. Reprod. | pmid:9603267 |
| Mellon SH and Bair SR | 25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor-1 (SF-1). | 1998 | Endocrinology | pmid:9607816 |
| Bucci C et al. | Free fatty acids modulate LDL receptor activity in BHK-21 cells. | 1998 | Atherosclerosis | pmid:9622276 |
| Rosenfeld JM and Osborne TF | HLH106, a Drosophila sterol regulatory element-binding protein in a natural cholesterol auxotroph. | 1998 | J. Biol. Chem. | pmid:9632664 |
| Dushkin M et al. | Effects of oxysterols upon macrophage and lymphocyte functions in vitro. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9644113 |
| Stengel D et al. | Inhibition of LPL expression in human monocyte-derived macrophages is dependent on LDL oxidation state: a key role for lysophosphatidylcholine. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9672079 |
| Fu Q et al. | Control of cholesterol biosynthesis in Schwann cells. | 1998 | J. Neurochem. | pmid:9681444 |
| Thewke DP et al. | Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins. | 1998 | J. Biol. Chem. | pmid:9694903 |
| Chang JY et al. | Cholesterol oxides induce programmed cell death in microglial cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9731219 |
| Kato H et al. | Macrophage inhibition of lymphocyte and tumor cell growth is mediated by 25-hydroxycholesterol in the cell membrane. | 1998 | Int. Arch. Allergy Immunol. | pmid:9751851 |
| Nohturfft A et al. | Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9789003 |
| Christenson LK et al. | Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions. | 1998 | J. Biol. Chem. | pmid:9804848 |
| Storey MK et al. | Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol. | 1998 | Biochem. J. | pmid:9806908 |
| Moog C et al. | Oxysterols, but not cholesterol, inhibit human immunodeficiency virus replication in vitro. | 1998 | Antivir. Chem. Chemother. | pmid:9865387 |
| Holleran AL et al. | Effect of tamoxifen on cholesterol synthesis in HepG2 cells and cultured rat hepatocytes. | 1998 | Metab. Clin. Exp. | pmid:9867082 |
| Lagace TA et al. | Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. | 1999 | J. Lipid Res. | pmid:9869656 |
| Du EZ et al. | Translocation-arrested apolipoprotein B evades proteasome degradation via a sterol-sensitive block in ubiquitin conjugation. | 1999 | J. Biol. Chem. | pmid:9880570 |
| Ayala-Torres S et al. | Apoptosis induced by oxysterol in CEM cells is associated with negative regulation of c-myc. | 1999 | Exp. Cell Res. | pmid:9882528 |
| Sparrow SM et al. | U18666A inhibits intracellular cholesterol transport and neurotransmitter release in human neuroblastoma cells. | 1999 | Neurochem. Res. | pmid:9973239 |