MeSH term | MeSH ID | Detail |
---|---|---|
Plaque, Amyloid | D058225 | 19 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Hypercholesterolemia | D006937 | 91 associated lipids |
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cerebrosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Plaque, Amyloid | D058225 | 19 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Hypercholesterolemia | D006937 | 91 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Norlin M et al. | 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). | 2000 | J. Lipid Res. | pmid:11013305 |
Lütjohann D et al. | Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. | 2000 | J. Lipid Res. | pmid:10681402 |
Russell DW | Oxysterol biosynthetic enzymes. | 2000 | Biochim. Biophys. Acta | pmid:11111082 |
Bretillon L et al. | Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. | 2000 | J. Lipid Res. | pmid:10787445 |
Meaney S et al. | Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique: cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice. | 2000 | Biochim. Biophys. Acta | pmid:10903480 |
Li-Hawkins J et al. | Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. | 2000 | J. Biol. Chem. | pmid:10748047 |
Papassotiropoulos A et al. | Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease. | 2000 | Neuroreport | pmid:10884051 |
Bretillon L et al. | Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases. | 2000 | Neurosci. Lett. | pmid:11027840 |
Li D and Spencer TA | Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. | 2000 | Steroids | pmid:10978732 |
Kölsch H et al. | The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. | 1999 | Brain Res. | pmid:9914453 |