MeSH term | MeSH ID | Detail |
---|---|---|
Plaque, Amyloid | D058225 | 19 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Hypercholesterolemia | D006937 | 91 associated lipids |
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cerebrosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Plaque, Amyloid | D058225 | 19 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Hypercholesterolemia | D006937 | 91 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sodero AO et al. | Cholesterol loss during glutamate-mediated excitotoxicity. | 2012 | EMBO J. | pmid:22343944 |
Popp J et al. | Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. | 2012 | J. Neurochem. | pmid:22845771 |
Saint-Pol J et al. | Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-β peptide accumulation. | 2012 | J. Alzheimers Dis. | pmid:22433669 |
Zuliani G et al. | Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study. | 2011 | BMC Neurol | pmid:21970714 |
Jeitner TM et al. | Oxysterol derivatives of cholesterol in neurodegenerative disorders. | 2011 | Curr. Med. Chem. | pmid:21428891 |
Mateos L et al. | Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. | 2011 | J. Biol. Chem. | pmid:21628469 |
Seet RC et al. | Oxidative damage in ischemic stroke revealed using multiple biomarkers. | 2011 | Stroke | pmid:21700941 |
Fourgeux C et al. | 24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma. | 2011 | Chem. Phys. Lipids | pmid:21531213 |
Shafaati M et al. | Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. | 2011 | J. Intern. Med. | pmid:21486371 |
Yamanaka K et al. | 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. | 2011 | J. Biol. Chem. | pmid:21613228 |