MeSH term | MeSH ID | Detail |
---|---|---|
Plaque, Amyloid | D058225 | 19 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Hypercholesterolemia | D006937 | 91 associated lipids |
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cerebrosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Plaque, Amyloid | D058225 | 19 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Hypercholesterolemia | D006937 | 91 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Testa G et al. | Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. | 2014 | PLoS ONE | pmid:24802026 |
Lütjohann D et al. | Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8790411 |
Stiles AR et al. | Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25201972 |
Soncini M et al. | 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27671648 |
Zhang J and Liu Q | Cholesterol metabolism and homeostasis in the brain. | 2015 | Protein Cell | pmid:25682154 |
Okabe A et al. | Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death. | 2013 | Redox Biol | pmid:24371802 |
Zarrouk A et al. | Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity. | 2015 | Rev. Neurol. (Paris) | pmid:25577946 |
Leoni V | Oxysterols as markers of neurological disease--a review. | 2009 | Scand. J. Clin. Lab. Invest. | pmid:19199127 |
Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
Vo DK et al. | 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8. | 2015 | Steroids | pmid:25697054 |