| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
Total
4
Cerebrosterol
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cerebrosterol?
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cerebrosterol
PubChem Associated disorders and diseases
What pathways are associated with Cerebrosterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cerebrosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Cerebrosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Cerebrosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Cerebrosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Cerebrosterol?
Mouse Model
Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Cerebrosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Papassotiropoulos A et al. | A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. | 2005 | J Clin Psychiatry | pmid:16013913 |
| Solfrizzi V et al. | Circulating biomarkers of cognitive decline and dementia. | 2006 | Clin. Chim. Acta | pmid:16139826 |
| Karrenbauer VD et al. | Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis. | 2006 | Clin Neurol Neurosurg | pmid:16144738 |
| Thelen KM et al. | Effect of pravastatin on plasma sterols and oxysterols in men. | 2006 | Eur. J. Clin. Pharmacol. | pmid:16385401 |
| Leoni V et al. | Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment? | 2006 Apr 10-17 | Neurosci. Lett. | pmid:16406316 |
| Abildayeva K et al. | 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. | 2006 | J. Biol. Chem. | pmid:16524875 |
| Panzenboeck U et al. | Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16530456 |
| Kölsch H et al. | Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease. | 2006 | Int. J. Mol. Med. | pmid:16596262 |
| Lukiw WJ | Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer's disease. | 2006 | Expert Rev Neurother | pmid:16734516 |
| Thelen KM et al. | High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. | 2006 | J Clin Pharmacol | pmid:16809807 |
| He X et al. | Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. | 2006 | J. Neuropathol. Exp. Neurol. | pmid:16825952 |
| Lütjohann D | Cholesterol metabolism in the brain: importance of 24S-hydroxylation. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866909 |
| Björkhem I et al. | Oxysterols and Alzheimer's disease. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866910 |
| Fujiyoshi M et al. | 24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression. | 2007 | J. Neurochem. | pmid:17101031 |
| Burkard I et al. | Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. | 2007 | Atherosclerosis | pmid:17107679 |
| Björkhem I | Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. | 2006 | J. Intern. Med. | pmid:17116000 |
| Chen W et al. | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. | 2007 | Cell Metab. | pmid:17189208 |
| Karu K et al. | Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. | 2007 | J. Lipid Res. | pmid:17251593 |
| Björkhem I | Rediscovery of cerebrosterol. | 2007 | Lipids | pmid:17393206 |
| Teunissen CE et al. | 24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis. | 2007 | J. Neurosci. Res. | pmid:17410599 |
| Hansson M et al. | Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. | 2007 | J. Intern. Med. | pmid:17444890 |
| Joffre C et al. | Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. | 2007 | Curr. Eye Res. | pmid:17453947 |
| Khripach VA et al. | [A new synthesis of cerebrosterol and its 24-epimer from lithocholic acid]. | 2007 Mar-Apr | Bioorg. Khim. | pmid:17476989 |
| Famer D et al. | Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17532301 |
| Valenza M et al. | Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation. | 2007 | Hum. Mol. Genet. | pmid:17613541 |
| Kristofiková Z et al. | Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers. | 2008 | Neurochem. Res. | pmid:17717740 |
| Shafaati M et al. | Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders. | 2007 | Neurosci. Lett. | pmid:17822846 |
| Ohtsuki S et al. | Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier. | 2007 | J. Neurochem. | pmid:17868302 |
| Umetani M et al. | 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. | 2007 | Nat. Med. | pmid:17873880 |
| Koschack J et al. | Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. | 2009 | Neurobiol. Aging | pmid:18061309 |
| Wang Y et al. | The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. | 2008 | J. Proteome Res. | pmid:18303831 |
| DeBarber AE et al. | Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol. | 2008 | Anal. Biochem. | pmid:18555788 |
| Weiner MF et al. | Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. | 2008 | Brain Inj | pmid:18568715 |
| Leoni V et al. | Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease. | 2008 | Brain | pmid:18772220 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Rantham Prabhakara JP et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. | 2008 | J. Neurochem. | pmid:19014385 |
| Bang HJ et al. | A comparison of the potential unfavorable effects of oxycholesterol and oxyphytosterol in mice: different effects, on cerebral 24S-hydroxychoelsterol and serum triacylglycerols levels. | 2008 | Biosci. Biotechnol. Biochem. | pmid:19060413 |
| Prasanthi JR et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. | 2009 | Mol Neurodegener | pmid:19126211 |
| Leoni V | Oxysterols as markers of neurological disease--a review. | 2009 | Scand. J. Clin. Lab. Invest. | pmid:19199127 |
| Kölsch H et al. | CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. | 2009 | Eur. Psychiatry | pmid:19286353 |
| Liao WL et al. | Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry. | 2009 | Biochemistry | pmid:19317426 |
| Seet RC et al. | Oxidative damage in dengue fever. | 2009 | Free Radic. Biol. Med. | pmid:19427377 |
| Shafaati M et al. | The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo. | 2010 | J. Lipid Res. | pmid:19474457 |
| Fourgeux C et al. | Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19553612 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Cook IT et al. | 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation. | 2009 | Drug Metab. Dispos. | pmid:19589875 |
| Hudry E et al. | Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. | 2010 | Mol. Ther. | pmid:19654569 |
| Zhao S et al. | Polar metabolite of cholesterol induces rat cognitive dysfunctions. | 2009 | Neuroscience | pmid:19699274 |
| Cartagena CM et al. | 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. | 2010 | Brain Res. | pmid:20053345 |
| Wang Y et al. | A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). | 2010 | Biochim. Biophys. Acta | pmid:20211758 |