MeSH term | MeSH ID | Detail |
---|---|---|
Plaque, Amyloid | D058225 | 19 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cerebrosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Plaque, Amyloid | D058225 | 19 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sugimoto H et al. | Method development for the determination of 24S-hydroxycholesterol in human plasma without derivatization by high-performance liquid chromatography with tandem mass spectrometry in atmospheric pressure chemical ionization mode. | 2015 | J Sep Sci | pmid:26249017 |
Vo DK et al. | 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8. | 2015 | Steroids | pmid:25697054 |
Pinçon A et al. | Increased susceptibility of dyslipidemic LSR+/- mice to amyloid stress is associated with changes in cortical cholesterol levels. | 2015 | J. Alzheimers Dis. | pmid:25690661 |
Wood WG et al. | Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis. | 2014 | J. Neurochem. | pmid:24329875 |
Linsenbardt AJ et al. | Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. | 2014 | Neuropharmacology | pmid:24878244 |
Leoni V and Caccia C | Study of cholesterol metabolism in Huntington's disease. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24525128 |
Stiles AR et al. | Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25201972 |
Gamba P et al. | Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. | 2014 | Aging Cell | pmid:24612036 |
Fourgeux C et al. | In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24491555 |
Meljon A et al. | Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24491562 |