MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Plaque, Amyloid | D058225 | 19 associated lipids |
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cerebrosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cartagena CM et al. | 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. | 2010 | Brain Res. | pmid:20053345 |
Ullrich C et al. | Effects of cholesterol and its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices. | 2010 | Pharmacology | pmid:20571288 |
Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
Wang Y et al. | A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). | 2010 | Biochim. Biophys. Acta | pmid:20211758 |
Kölsch H et al. | CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. | 2009 | Eur. Psychiatry | pmid:19286353 |
Leoni V | Oxysterols as markers of neurological disease--a review. | 2009 | Scand. J. Clin. Lab. Invest. | pmid:19199127 |
Liao WL et al. | Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry. | 2009 | Biochemistry | pmid:19317426 |
Prasanthi JR et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. | 2009 | Mol Neurodegener | pmid:19126211 |
Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
Seet RC et al. | Oxidative damage in dengue fever. | 2009 | Free Radic. Biol. Med. | pmid:19427377 |